Panadol CF Night 100 Caplets

Paracetamol, also known as acetaminophen, has a primary mechanism of action that involves reducing the production of prostaglandins, which are inflammatory mediators. Specifically, it works by inhibiting the enzyme cyclooxygenase (COX) in the central nervous system and the hypothalamus, which is responsible for regulating body temperature. This inhibition leads to a decrease in the synthesis of prostaglandin E2, thereby reducing pain and fever. Unlike non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol has minimal anti-inflammatory effects, as it does not significantly inhibit peripheral COX involved in inflammation. This selective mechanism contributes to paracetamol's analgesic and antipyretic properties, making it effective in relieving mild to moderate pain and reducing fever without affecting inflammation.

Paracetamol

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Analgesic/Antipyretic

Capsule

The following are the uses of Paracetamol 500mg Capsule:

• Used for relieving mild to moderate pain such as headaches, toothaches, and post-vaccination fever.
• Used for reducing fever and managing discomfort associated with colds and flu.
• Used for easing pain and inflammation caused by conditions like arthritis.
• Used for treating aches and pains from injuries or minor surgeries.
• Used for managing menstrual cramps and providing temporary relief.
• Used for alleviating pain from muscle strains or sprains.
• Used for reducing discomfort and fever in children, under medical supervision.

In the case of an overdose of Paracetamol 500mg Capsules, it is important to act quickly. Initial symptoms may include nausea, vomiting, and abdominal pain, but severe cases can lead to liver damage and failure. Prompt medical intervention is necessary to prevent potential life-threatening complications. Treatment options include gastric decontamination, administration of acetylcysteine, and supportive care to manage symptoms and prevent further liver injury. Timely medical care is essential to ensure the best possible outcome.

In the case of a missed dose of Paracetamol 500mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you have missed multiple doses, consult your healthcare provider for guidance on how to safely resume your medication regimen. Remember, it is crucial to adhere to the prescribed dosage and frequency of Paracetamol to ensure its effectiveness and avoid potential side effects.

To take Paracetamol 500mg Capsule, swallow the capsule whole with a glass of water, preferably with or after a meal, following the dosage instructions provided by your healthcare professional or as directed on the medication label.

Following are the conditions/situations when Paracetamol 500mg Capsule should not be taken:

• Avoid if you have severe liver or kidney disease, as Paracetamol can worsen these conditions.
• Do not take if you are allergic to Paracetamol or any of its ingredients.
• Not suitable for individuals with G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency.
• Contraindicated in patients with acute alcoholism or chronic alcohol dependence.
• Should not be used for long-term pain relief without consulting a doctor.
• Avoid if you have a history of gastrointestinal bleeding or a bleeding disorder.
• Not recommended for individuals with severe heart disease or hypertension.

The side effects of Paracetamol 500mg Capsule may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Loss of appetite
• Skin rash or itching
• Allergic reactions (e.g., hives, swelling)
• Liver damage (in rare cases, with prolonged use or high doses)
• Increased sweating
• Unusual bleeding or bruising

Following are the precautions and warnings:

• Paracetamol 500mg Capsule should not be used for long periods without medical supervision as it may cause liver damage.
• Patients with liver or kidney disease must use this medication with caution and under medical supervision.
• Alcohol consumption should be avoided while taking this medicine as it can increase the risk of liver damage.
• Do not exceed the recommended dose, as an overdose can lead to severe liver and kidney damage.
• If symptoms persist or worsen after a few days of treatment, consult a healthcare professional immediately.
• This medication is not recommended for individuals with a known allergy to paracetamol or any other ingredients in the capsule.
• It should be used with caution in elderly patients as they may be more susceptible to side effects.
• Patients with a history of gastrointestinal problems should be monitored for signs of gastrointestinal bleeding.

Following are the drug interactions for Paracetamol 500mg Capsule:

• When taken with other central nervous system depressants like opioids (e.g., codeine, oxycodone) or benzodiazepines, it may increase the risk of respiratory depression and sedation.
• Alcohol consumption while taking paracetamol can increase the risk of liver damage, especially with chronic use.
• The anticoagulant effect of warfarin may be altered by paracetamol, requiring close monitoring of INR (International Normalized Ratio).
• Using paracetamol with certain anti-epileptic drugs like carbamazepine or phenytoin may affect seizure control and require dosage adjustments.
• Paracetamol can increase the risk of hepatotoxicity when used with other potentially hepatotoxic drugs, such as isoniazid or certain antifungal medications.
• Prolonged use with highly protein-bound drugs like oral anticoagulants or phenytoin may affect drug distribution and require dosage adjustments.
• Caution is advised when combining paracetamol with herbal supplements like St. John's Wort, as it may affect drug metabolism.

Following are the food interactions for Paracetamol 500mg Capsule:

• Avoid excessive alcohol consumption while taking Paracetamol, as it can increase the risk of liver damage, especially with long-term use.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Paracetamol, potentially leading to increased drug levels in the body.
• High-fat meals may delay the absorption of Paracetamol, but this effect is usually not clinically significant.
• Avoid caffeine-rich foods and beverages, as excessive caffeine intake in combination with Paracetamol may increase the risk of liver damage.
• Avoid herbal supplements like St. John's Wort, as it can affect the metabolism of Paracetamol, potentially reducing its effectiveness.
• Ensure adequate fluid intake to prevent dehydration, especially when taking Paracetamol for fever or pain associated with illness.
• Avoid high-salt foods as Paracetamol may increase sodium levels in the body, particularly in individuals with certain medical conditions.
• No significant food interactions are known to directly impact the effectiveness of Paracetamol, but consult your healthcare provider for personalized advice.

Paracetamol 500mg capsules should be stored in a cool, dry place, preferably in a medicine cabinet or similar storage area, ensuring it remains out of reach of children and pets. Maintain a consistent room temperature, avoiding exposure to direct sunlight, heat, or moisture to prevent degradation. Always keep the capsules in their original packaging or container, tightly sealed, to ensure their integrity and protect against environmental factors. When disposing of unused or expired capsules, it is crucial to follow local guidelines or consult a pharmacist. Do not dispose of them in household waste, and never flush medications down the toilet or pour them into drains, as this can cause environmental harm. Instead, seek advice from healthcare professionals or local waste management authorities for appropriate disposal methods.

Following are the quick tips for Paracetamol 500mg Capsule:

• Consult a doctor for proper dosage and duration, especially for children and elderly patients.
• Swallow the capsule whole with a full glass of water for easy swallowing.
• Avoid alcohol consumption as it may increase the risk of liver damage.
• Inform your doctor if you have liver or kidney issues before taking this medication.
• Do not take more than the recommended dose; it may cause liver damage.
• Store at room temperature, away from moisture and heat.
• Keep a gap of at least 4 hours between doses to prevent overdose.
• Seek immediate medical attention if you experience skin reactions or persistent nausea.