Panadol Night Tablet 500/25mg 20's

Diphenhydramine, an antihistamine, primarily exerts its effects by competitively blocking H1 histamine receptors. This action alleviates symptoms associated with allergies and hypersensitivity reactions by reducing histamine-induced effects. Paracetamol, on the other hand, has a less understood mechanism but is believed to inhibit the synthesis of prostaglandins, which are involved in pain and inflammation signaling. Paracetamol's analgesic and antipyretic properties are attributed to its ability to block cyclooxygenase (COX) enzymes in the central nervous system, thereby reducing the production of prostaglandins and subsequently decreasing pain sensitivity and regulating body temperature.

Antihistamine, Analgesic

Tablet

The following are the uses of Diphenhydramine, paracetamol Tablet:

• Used for relieving mild to moderate pain such as headaches, toothaches, backaches, and menstrual cramps.
• Used for reducing fever and managing symptoms of cold and flu.
• Used for treating allergies and allergic reactions, including runny nose, sneezing, and itchy, watery eyes.
• Used for providing short-term relief from insomnia and aiding in falling asleep.
• Used for easing symptoms of upper respiratory allergies and common cold, like sneezing and runny nose.
• Used for reducing itching and inflammation caused by insect bites, rashes, or allergic skin reactions.
• Used for managing motion sickness and reducing symptoms like nausea and vomiting.
• Used for treating certain types of coughs by suppressing the cough reflex.

In the case of an overdose of Diphenhydramine and paracetamol tablets, the severity of symptoms can vary. Diphenhydramine overdose may lead to confusion, hallucinations, rapid heart rate, and seizures. Paracetamol overdose can cause liver damage, abdominal pain, and nausea. Prompt medical intervention is necessary, including contacting poison control or seeking emergency care. The treatment approach may involve supportive care, monitoring vital signs, and administering specific antidotes if required.

In the case of a missed dose of Diphenhydramine, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For paracetamol tablets, if you miss a dose, take it as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. It is important to maintain a consistent medication routine for optimal effectiveness.

To take the Diphenhydramine and Paracetamol Tablet, swallow the tablet whole with a glass of water, preferably with or after a meal, as directed by your healthcare professional, ensuring you follow the prescribed dosage and duration for optimal relief.

Following are the conditions or circumstances when Diphenhydramine, paracetamol Tablet should not be taken:

• Allergic Reactions. Do not use if you are allergic to diphenhydramine, paracetamol, or any other ingredients in the tablet
• Liver Disease. Avoid use in individuals with severe liver disease or liver failure, as paracetamol can cause liver toxicity
• Alcohol Consumption. Do not use if you have consumed alcohol or are planning to drink alcohol, as it can increase the risk of liver damage
• Pregnancy and Breastfeeding. Consult with a healthcare provider before using, especially if you are pregnant or breastfeeding
• Respiratory Conditions. Avoid use in individuals with respiratory issues such as asthma, COPD, or sleep apnea due to the sedative effect of diphenhydramine
• Glaucoma. Do not use if you have narrow-angle glaucoma, as diphenhydramine may increase intraocular pressure
• Urinary Retention. Avoid use if you have conditions like bladder obstruction or urinary retention, as diphenhydramine can worsen these symptoms
• Children. Not recommended for use in young children unless specifically advised by a healthcare provider, as it may cause excessive sedation or other side effects
• Other Sedatives. Avoid combining with other sedative medications, including alcohol, sleep aids, or tranquilizers, as it can cause excessive drowsiness and other adverse effects
• Kidney Disease. Use with caution if you have kidney disease, as paracetamol can accumulate and lead to toxicity
• Heart Disease. Consult with a healthcare provider if you have any heart-related conditions, as diphenhydramine can cause a decrease in heart rate

The side effects of Diphenhydramine and Paracetamol Tablet may include:

• Drowsiness or sedation
• Dry mouth
• Blurred vision
• Constipation
• Difficulty urinating
• Confusion (especially in elderly individuals)
• Skin rash or hives
• Nausea and vomiting

Here are the precautions and warnings for Diphenhydramine, Paracetamol Tablet:

• Avoid using this medication if you are allergic to diphenhydramine, paracetamol, or any other antihistamines or analgesics.
• Consult your doctor if you have a medical history of liver or kidney disease, asthma, glaucoma, or urinary retention, as this medication may require dosage adjustments.
• Alcohol consumption should be avoided as it can increase the risk of side effects and drowsiness.
• Do not perform activities that require mental alertness, such as driving or operating heavy machinery, as this medication can cause drowsiness.
• Elderly patients may be more sensitive to the side effects of this medication, especially dizziness and confusion.
• This medication is not recommended for children under 12 years of age unless prescribed by a doctor.
• If you are pregnant or breastfeeding, consult your healthcare provider before taking this medication as it may have potential risks to the fetus or infant.
• Always read the patient information leaflet provided with the medication for detailed information and instructions.

Following are the drug interactions for Diphenhydramine, paracetamol Tablet:

• May cause increased sedation when taken with other central nervous system depressants like benzodiazepines, alcohol, or opioids.
• Can inhibit the metabolism of certain medications metabolized by CYP2D6 enzymes, including some antidepressants, antipsychotics, and beta-blockers, leading to increased levels of these drugs.
• Concomitant use with monoamine oxidase inhibitors (MAOIs) is contraindicated, as it may cause severe adverse effects.
• May decrease the effectiveness of anticholinesterase agents used in myasthenia gravis.
• Antihistamines like diphenhydramine can reduce the absorption of certain antibiotics (e.g., tetracyclines).
• Paracetamol can increase the risk of liver damage when taken with other potentially hepatotoxic drugs.
• May reduce the effectiveness of certain antihypertensive medications due to its anticholinergic properties.

Following are the food interactions for Diphenhydramine, paracetamol Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can inhibit the CYP450 enzyme system, potentially affecting drug metabolism.
• Alcohol intake should be minimized or avoided as it can increase the sedative effects of Diphenhydramine, leading to enhanced drowsiness and impaired coordination.
• Caffeine-containing products like coffee, tea, or energy drinks may counteract the sedative effect of Diphenhydramine, potentially reducing its effectiveness for sleep aid purposes.
• Spicy foods should be consumed with caution as they can potentially irritate the stomach lining, which may be a concern when taking Paracetamol, especially in high doses.
• High-fat meals may slightly delay the absorption of Paracetamol, but this effect is generally not clinically significant.
• Eating a balanced diet is essential when taking Paracetamol regularly to maintain liver health, as this medication is primarily metabolized by the liver.
• Ensure adequate fluid intake, especially water, to support kidney function and aid in the elimination of Paracetamol from the body.
• No specific food restrictions are associated with Diphenhydramine and Paracetamol combination tablets, but it's advisable to consult a healthcare professional for personalized advice.

Diphenhydramine and paracetamol tablets should be stored in a secure and dry location, preferably in their original container, at room temperature, and away from excessive heat, direct sunlight, and moisture. It is crucial to keep the medication out of the reach of children and pets to prevent accidental consumption. Do not store in the bathroom medicine cabinet or any other humid environment. When disposing of unused or expired tablets, do not throw them into the trash or flush them down the toilet. Instead, follow local guidelines for medication disposal, which may include returning them to a pharmacy or a designated collection point for safe disposal, ensuring responsible environmental practices. Always handle medication disposal with care to minimize potential risks.

Following are the quick tips for Diphenhydramine, Paracetamol Tablet:

• Consult a healthcare professional for dosage and usage instructions, especially for children and the elderly.
• Swallow the tablet whole with water; do not crush or chew.
• Avoid alcohol consumption while taking this medication.
• Do not drive or operate heavy machinery until you know how this medication affects you.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Discontinue use and seek medical attention if you experience severe allergic reactions or unusual symptoms.