PANDOM TAB

Domperidone primarily acts as a dopamine D2 receptor antagonist in the chemoreceptor trigger zone (CTZ) of the brain, inhibiting dopamine-induced nausea and vomiting. It increases gastric motility by blocking peripheral dopamine receptors and enhancing gastrointestinal peristalsis. Pantoprazole, on the other hand, is a proton pump inhibitor (PPI) that suppresses gastric acid secretion. It specifically targets the H+/K+-ATPase (proton pump) in the parietal cells of the stomach, inhibiting the final step of gastric acid secretion. By binding to these pumps, pantoprazole effectively reduces gastric acid production, creating a more favorable environment for the healing of gastrointestinal issues.

Domperidone, Pantoprazole 40mg

Prokinetic, Proton Pump Inhibitor

Tablet

The following are the uses of Domperidone, Pantoprazole 40mg Tablet:

• Used for treating conditions like gastroesophageal reflux disease (GERD) and peptic ulcers.
• Used to reduce stomach acid and relieve heartburn and indigestion.
• Used for managing nausea and vomiting associated with certain medical conditions.
• Used to enhance gastrointestinal motility and aid in stomach emptying.
• Used for gastroparesis, helping to improve digestion and reduce symptoms.
• Used to prevent nausea and vomiting during cancer treatment or after surgery.
• Used to treat conditions causing excessive acid production, offering symptom relief.

In the case of an overdose of Domperidone and Pantoprazole 40mg tablets, individuals may experience severe side effects. These can include nausea, vomiting, abdominal pain, and in extreme cases, irregular heart rhythms and cardiac issues. It is crucial to seek medical advice promptly if an overdose is suspected, as early intervention can help manage and alleviate potential complications. Timely medical assessment and treatment are essential to ensure the best possible outcome.

In the case of a missed dose of Domperidone, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Pantoprazole 40mg tablets, if you miss a dose, take it as soon as you remember, but if it is close to the time of your next dose, skip the missed dose and continue with your regular dosing routine. It is important to try to take your medications at the same time each day to maintain consistent levels in your body.

To take Domperidone and Pantoprazole 40mg tablets, swallow the tablets whole with a glass of water, preferably in the morning before food, as directed by your doctor, usually once or twice a day, depending on your medical condition and response to the medication.

Following are the conditions/situations when Domperidone and Pantoprazole 40mg Tablet should not be used:

• Avoid using if you have a known allergy or hypersensitivity to Domperidone, Pantoprazole, or other similar proton pump inhibitors or prokinetic agents.
• Not recommended for individuals with liver problems or impaired liver function.
• Should not be used in patients with severe kidney disease or those with significantly reduced kidney function.
• Contraindicated in patients with a history of cardiac arrhythmias or prolonged QT interval.
• Avoid using if you have a stomach ulcer or gastrointestinal bleeding until a clear diagnosis is established.
• Not suitable for individuals with low magnesium levels or conditions causing low magnesium levels.
• Should not be used if you have an adrenal gland tumor (pheochromocytoma).
• Avoid using if you have an overproduction of the hormone prolactin (prolactinoma).
• Contraindicated in patients with mechanical bowel obstructions or perforations.

The side effects may include:

• Dry mouth
• Headache
• Diarrhea
• Abdominal pain
• Fatigue
• Skin rashes
• Dizziness
• Nausea
• Headache
• Diarrhea
• Abdominal pain
• Dizziness
• Skin irritation
• Joint pain

Following are the precautions and warnings for Domperidone, Pantoprazole 40mg Tablet:

• This medication should not be used in patients with known hypersensitivity or allergy to Domperidone or Pantoprazole or any other ingredients in the tablet.
• It should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• Patients with low magnesium levels or those at risk of osteoporosis should be monitored regularly, as prolonged use may worsen these conditions.
• Not recommended for use in children and adolescents under 18 years of age.
• Elderly patients may be more susceptible to side effects, especially dizziness and confusion.
• Domperidone may cause QT prolongation, so it should be used with caution in patients with heart conditions or those taking other medications affecting QT interval.
• This medication may interact with other drugs, including antacids, anti-fungal medications, and some antibiotics, so inform your doctor about all medications you are taking.
• Consult your doctor if you have a history of any other medical conditions or if you are pregnant or breastfeeding before taking this medication.

Following are the drug interactions for Domperidone and Pantoprazole 40mg Tablet:

• Domperidone may interact with drugs metabolized by CYP3A4, like ketoconazole, leading to increased levels of these medications.
• Concomitant use with strong CYP3A4 inhibitors like ritonavir can increase Domperidone levels, potentially causing adverse effects.
• Pantoprazole can reduce the absorption of drugs that require acidic pH, such as ketoconazole and atazanavir.
• It may decrease the effectiveness of clopidogrel, an antiplatelet medication, potentially affecting blood clotting.
• The effects of warfarin, an anticoagulant, may be altered by Pantoprazole, requiring close monitoring of INR.
• Drugs that are dependent on gastric pH for absorption, like certain antibiotics, may have reduced bioavailability when taken with Pantoprazole.
• Concomitant use with digoxin can increase its concentration, requiring monitoring for digoxin toxicity.
• Antacids containing aluminum or magnesium may decrease the absorption of Pantoprazole if taken simultaneously.

Following are the food interactions for Domperidone and Pantoprazole 40mg Tablet:

• Avoid consuming grapefruit and grapefruit juice as these can reduce the metabolism of Pantoprazole, leading to increased drug levels and potential side effects.
• Alcohol intake should be minimized as it can irritate the stomach and potentially reduce the effectiveness of Domperidone in treating gastrointestinal issues.
• Spicy and fatty foods should be consumed in moderation as they can trigger acid reflux and reduce the efficacy of Pantoprazole in managing acid-related conditions.
• Dairy products, especially milk, might interfere with the absorption of Domperidone, so it's advisable to take the medication at least 30 minutes before or after consuming milk.
• Caffeinated beverages like coffee and tea may stimulate acid secretion and potentially reduce the therapeutic effect of Pantoprazole.
• Avoid high-sodium foods as Pantoprazole can increase sodium levels in the body, and excessive sodium intake may counteract the medication's benefits.
• Consuming a healthy, balanced diet rich in fruits, vegetables, and whole grains can support the overall effectiveness of the treatment.
• Follow the advice of your healthcare provider regarding any specific dietary restrictions or recommendations tailored to your condition.

Domperidone and Pantoprazole 40mg Tablets should be stored in a cool, dry area, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity. It is crucial to keep them away from heat sources like radiators or stoves, as temperature fluctuations can impact their effectiveness. Always check the expiration date, and for disposal, do not flush or pour the medication down the drain. Consult a pharmacist or healthcare professional for safe disposal methods, and ensure the medication is kept away from children to prevent accidental consumption. Proper storage and disposal practices are vital for maintaining the quality and safety of these tablets.

Following are the quick tips for Domperidone and Pantoprazole 40mg Tablet:

• Consult your doctor before use, especially if you have underlying health conditions.
• Take the medication as directed by your healthcare provider.
• Do not crush or chew the tablet; swallow it whole with water.
• Take the tablet on an empty stomach, at least 1 hour before meals.
• Maintain a consistent schedule for taking the medication.
• Avoid alcohol consumption while using this medication.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Inform your doctor about all medications you are currently taking to prevent potential interactions.