PAPVERIN INJ (1S)

Pantoprazole 20mg Injection works by inhibiting the proton pump, an enzyme found in the stomach's parietal cells, which is responsible for the production of gastric acid. It specifically targets the H+/K+-ATPase pump, blocking the final step of gastric acid secretion. By inhibiting this pump, pantoprazole significantly reduces the production of stomach acid, leading to a rapid and long-lasting reduction in gastric acidity. This mechanism of action helps in the management of conditions where excessive stomach acid is a concern, such as gastroesophageal reflux disease (GERD) and peptic ulcer disease.

Proton pump inhibitor.

Injection

The following are the uses of Pantoprazole 20mg Injection:

• Used for treating gastroesophageal reflux disease (GERD) and relieving symptoms like heartburn and acid regurgitation.
• Used for managing erosive esophagitis and promoting healing of the esophagus.
• Used to reduce stomach acid production in conditions like Zollinger-Ellison syndrome.
• Used to prevent and treat stress-induced ulcers in intensive care patients.
• Used for providing rapid relief in severe acid-related conditions when oral medication is not feasible.
• Used as a short-term treatment to manage acid-related symptoms until oral therapy can be initiated.
• Used to improve comfort and reduce acid-related complications in hospitalized patients.

In the case of an overdose of Pantoprazole 20mg Injection, it is important to seek medical assistance promptly. Overdose symptoms may include severe dizziness, fainting, or a rapid or pounding heartbeat. If an overdose occurs, contact a healthcare professional or a poison control center immediately for guidance. They can provide specific instructions and support to manage the situation effectively, ensuring the best possible outcome.

In the case of a missed dose of Pantoprazole 20mg Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for guidance on how to adjust your medication schedule and ensure you receive the proper treatment.

To administer Pantoprazole 20mg Injection, insert the needle into the vial, withdraw the prescribed dose, and inject it slowly into the vein, ensuring the injection is given as directed by your healthcare professional, typically once a day.

Here are the conditions and situations when Pantoprazole 20mg Injection should not be used:

• Should not be used in patients with known hypersensitivity or severe allergic reactions to Pantoprazole or other proton pump inhibitors (PPIs).
• Contraindicated in patients with low magnesium levels (hypomagnesemia) or conditions causing low magnesium levels.
• Not recommended for long-term use in patients without a clear indication, as prolonged use may increase the risk of certain side effects.
• Should be avoided in patients with severe liver impairment, as the dosage adjustment is necessary in such cases.
• Contraindicated in patients with acute porphyria, a rare metabolic disorder.
• Not suitable for the treatment of gastrinoma or other conditions causing excess gastric acid secretion.
• Should be used with caution and avoided if possible in patients with osteoporosis or at high risk of bone fractures, as long-term use may increase fracture risk.
• Should not be used to treat gastrointestinal infections or mask symptoms of other serious conditions.

The side effects of Pantoprazole 20mg Injection may include:

• Headache
• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Dizziness
• Skin rashes or itching
• Joint pain
• Increased liver enzymes

Following are the precautions and warnings for Pantoprazole 20mg Injection:

• Do not use if you are allergic to Pantoprazole or other proton pump inhibitors.
• Long-term use may lead to vitamin B12 deficiency, so regular monitoring is necessary.
• Patients with liver problems should use with caution and under medical supervision.
• This medication may cause hypomagnesemia, so magnesium levels should be monitored during prolonged treatment.
• Elderly patients may be more susceptible to side effects, particularly bone fractures and infections.
• Inform your doctor if you have any medical conditions, especially heart or lung diseases, before using this medication.
• Pantoprazole may interact with other medicines; inform your healthcare provider about all the medications you are taking.

Following are the drug interactions for Pantoprazole 20mg Injection:

• Concomitant use with Clopidogrel may reduce the effectiveness of Clopidogrel, potentially increasing the risk of cardiovascular events.
• Pantoprazole can decrease the absorption of drugs that require an acidic environment, such as Ketoconazole and Atazanavir.
• May reduce the effectiveness of Methotrexate due to altered renal excretion.
• The blood-thinning effects of Warfarin may be influenced by Pantoprazole, requiring closer monitoring of INR values.
• It can increase plasma concentrations of drugs metabolized by CYP2C19, including Diazepam and Phenytoin.
• When used with Digoxin, Pantoprazole may slightly increase Digoxin levels.
• Interactions with herbal supplements like St. John's Wort may reduce Pantoprazole's effectiveness.

Following are the food interactions for Pantoprazole 20mg Injection:

• Avoid consuming grapefruit or grapefruit juice as they can significantly increase the concentration of Pantoprazole in the blood, leading to potential side effects.
• Alcohol consumption should be limited or avoided as it can reduce the effectiveness of Pantoprazole and may cause additional stomach irritation.
• Avoid high-fat meals as they can delay the absorption of Pantoprazole, affecting its efficacy.
• Caffeine-containing beverages like coffee, tea, or energy drinks may increase stomach acid production and should be consumed in moderation.
• Spicy foods may irritate the stomach lining and should be consumed sparingly while using Pantoprazole.
• Avoid excessive consumption of acidic foods like citrus fruits and tomatoes, as they can trigger acid reflux and potentially reduce the medication's effectiveness.
• Dairy products may interact with Pantoprazole, especially in individuals with lactose intolerance, and should be consumed with caution.
• Consult your healthcare provider for personalized dietary recommendations during the treatment period.

Pantoprazole 20mg Injection should be stored in a secure and controlled environment, preferably in a designated medication storage area. Keep the injections in a cool, dry place, away from direct sunlight and moisture, as exposure to light and heat can degrade the medication. Ensure the injections are stored in their original packaging, tightly sealed, to maintain sterility and prevent contamination. Do not refrigerate unless specified by the manufacturer. It is crucial to adhere to the recommended storage conditions to preserve the efficacy of the medication. When disposing of unused or expired injections, follow local guidelines and regulations. Do not dispose of them in regular trash or pour them down the drain; instead, contact a healthcare professional or pharmacist for guidance on proper disposal methods to ensure environmental safety. Keep the medication out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Pantoprazole 20mg Injection:

• Administer the injection as prescribed by your doctor, ensuring the prescribed dosage and frequency.
• Only trained medical professionals should administer this injection.
• Verify the patient's identity and confirm the injection site before administration.
• Use a sterile syringe and needle for the injection to prevent infection.
• Inject the medication slowly and smoothly to minimize discomfort.
• Dispose of used needles and syringes safely in designated sharps containers.
• If you experience any unusual symptoms after the injection, inform your healthcare provider immediately.