Pcam (0.5%) 25g Gel

Piroxicam gel exerts its anti-inflammatory and analgesic effects through its active ingredient, piroxicam, which belongs to the nonsteroidal anti-inflammatory drug (NSAID) class. It primarily inhibits cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2, which are involved in the synthesis of prostaglandins. By blocking these enzymes, piroxicam gel reduces the production of inflammatory mediators such as prostaglandins and thromboxanes, leading to decreased inflammation, pain, and swelling at the site of application. This localized action helps in alleviating symptoms associated with musculoskeletal conditions without significant systemic absorption.

Nonsteroidal anti-inflammatory drug (NSAID)

Gel

The following are the uses of Piroxicam Gel:

• Used for reducing inflammation and pain associated with osteoarthritis, rheumatoid arthritis, and other joint conditions.
• Used for treating acute muscle pain, strains, and sprains.
• Used for relieving post-surgical pain and swelling.
• Used for managing pain and stiffness in conditions like tendonitis and bursitis.
• Used for alleviating pain and inflammation in minor injuries and sports-related traumas.
• Used for providing symptomatic relief in gout attacks.
• Used for easing discomfort in conditions affecting the spine, such as ankylosing spondylitis.

Dose may be determined by the doctor. Adjustment may be required for people with renal and hepatic insufficiency

In the case of an overdose of Piroxicam Gel, several symptoms may occur, including gastrointestinal issues such as nausea, vomiting, and stomach pain. Skin reactions like rashes or itching may also appear. The severity of symptoms depends on the amount ingested. It is important to contact a healthcare professional or a poison control center for guidance and to provide information about the amount applied. They can offer specific advice and treatment options for managing the overdose.

In the case of a missed dose of Piroxicam Gel, it is generally advised to apply the gel as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Avoid applying extra gel to make up for the missed dose, as this may increase the risk of side effects. It's important to maintain a consistent dosing schedule, but if you miss a dose, simply resume the application as soon as possible and continue with the prescribed frequency.

To apply Piroxicam Gel, clean and dry the affected area, then gently massage a thin layer of the gel onto the skin, repeating this process twice a day or as directed by your healthcare professional.

Following are the conditions/situations when Piroxicam Gel should not be used:

• Avoid using if you have a known allergy or sensitivity to Piroxicam or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Do not use if you have a history of severe allergic reactions such as asthma, hives, or other respiratory problems triggered by aspirin or other NSAIDs.
• Contraindicated in individuals with active stomach or intestinal ulcers or bleeding disorders.
• Should not be used if you have recently undergone heart surgery.
• Avoid using on broken or infected skin.
• Not recommended for individuals with severe kidney or liver disease.
• Do not use Piroxicam Gel if you are in the third trimester of pregnancy.
• Contraindicated for children and adolescents under 18 years of age.
• Do not use if you have a history of aspirin-induced asthma.
• Should not be applied to the eyes, mouth, or open wounds.

The side effects of Piroxicam Gel may include:

• Skin rash or itching
• Redness or swelling at the application site
• Dry skin or peeling
• Burning or stinging sensation
• Blisters or sores
• Increased sensitivity to sunlight
• Dizziness or lightheadedness
• Gastrointestinal discomfort (stomach pain, diarrhea)

Following are the precautions and warnings for Piroxicam Gel:

• Avoid contact with eyes, nose, mouth, and other mucous membranes. In case of accidental contact, immediately rinse with water.
• Wash your hands thoroughly after applying the gel to avoid accidental transfer to sensitive areas.
• Do not apply the gel to open wounds, infected areas, or areas with skin conditions like eczema or psoriasis.
• Avoid using the gel on skin that is sunburned or exposed to extreme heat, as it may increase sensitivity.
• If you are pregnant or breastfeeding, consult your healthcare provider before using Piroxicam Gel.
• Inform your doctor if you have a history of gastrointestinal bleeding, asthma, or liver disease before starting this medication.
• Discontinue use and seek medical attention if you experience severe skin reactions, increased pain, or signs of an allergic reaction.
• Keep out of reach of children and pets. Store the gel in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Piroxicam Gel:

• Piroxicam may increase the risk of bleeding when taken with anticoagulants like warfarin or antiplatelet drugs such as aspirin, clopidogrel, or NSAIDs.
• The gel can interact with lithium, potentially increasing lithium levels in the body and leading to lithium toxicity.
• When used with diuretics, especially loop diuretics, Piroxicam may reduce their diuretic and antihypertensive effects.
• Antihypertensive medications, including ACE inhibitors and beta-blockers, may have their effects diminished by Piroxicam.
• Methotrexate levels can be elevated when used with Piroxicam, increasing the risk of methotrexate toxicity.
• The gel's renal excretion can be affected by probenecid, leading to increased Piroxicam levels.
• Diabetes medications, including insulin and oral hypoglycemic agents, may have their effects masked by Piroxicam, potentially leading to poor glycemic control.

Following are the food interactions to consider with Piroxicam Gel:

• Avoid or limit the consumption of foods rich in omega-3 fatty acids like salmon, tuna, flaxseeds, and walnuts, as they may increase the risk of bleeding when combined with Piroxicam.
• Reduce your intake of high-sodium foods like processed snacks, canned soups, and fast food, as Piroxicam can lead to sodium retention.
• Alcohol may increase the risk of gastrointestinal bleeding when used with Piroxicam, so it's best to limit or avoid alcoholic beverages.
• Avoid excessive caffeine intake from coffee, tea, or energy drinks, as Piroxicam can sometimes cause nervousness and insomnia.
• Consuming a diet high in fiber can be beneficial, especially when taking Piroxicam, as it may help reduce the risk of gastrointestinal side effects.
• Stay well-hydrated by drinking plenty of water, especially if you experience gastrointestinal discomfort while using Piroxicam Gel.
• Consider reducing your intake of spicy foods as they may exacerbate gastrointestinal symptoms when using Piroxicam.
• Always follow your healthcare provider's advice on dietary adjustments while using Piroxicam Gel.

Piroxicam Gel should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from direct sunlight, heat, and moisture. Keep the gel in its original container, tightly sealed, to maintain its integrity and prevent contamination. Regularly check the expiration date on the packaging, and dispose of any unused or expired gel promptly. Avoid flushing or pouring it down the drain; instead, follow local guidelines or consult your pharmacist for appropriate disposal methods. It is crucial to keep the gel out of the reach of children to prevent accidental exposure or ingestion. Proper storage and disposal practices help maintain the efficacy and safety of Piroxicam Gel.

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Following are the quick tips for Piroxicam Gel:

• Clean and dry the affected area before applying the gel.
• Apply a thin layer of the gel to the skin and gently rub it in.
• Wash your hands after application to avoid accidental contact with eyes or sensitive areas.
• Avoid applying the gel to broken or irritated skin.
• Do not cover the treated area with bandages or tight clothing.
• Use the gel as directed by your healthcare professional, usually 3-4 times a day.
• If you experience skin irritation, stop using the gel and consult your doctor.