Pcam (20mg) 1ml, 5 Ampoule Injections

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic effects. Its primary mechanism of action is through the inhibition of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. By blocking these enzymes, piroxicam interferes with the production of prostaglandins, which are key mediators of inflammation, pain, and fever. COX enzymes play a role in the synthesis of prostaglandins from arachidonic acid, and by inhibiting their activity, piroxicam reduces the production of these inflammatory mediators. This results in decreased inflammation, pain relief, and reduction of fever. Piroxicam's ability to inhibit both COX-1 and COX-2 contributes to its therapeutic effects in managing various inflammatory conditions.

Non-steroidal anti-inflammatory drug (NSAID)

injection

The following are the uses of Piroxicam 20mg injection:

• Used for relieving acute pain and inflammation, particularly in conditions like rheumatoid arthritis and osteoarthritis.
• Used for managing post-operative pain and reducing swelling after surgery.
• Used to treat acute gout attacks by reducing pain and inflammation.
• Used in the short-term treatment of acute musculoskeletal injuries.
• Used for pain relief in conditions such as ankylosing spondylitis and other inflammatory disorders.
• Used to alleviate discomfort and inflammation in soft tissue injuries.
• Used for controlling pain and inflammation in certain types of bursitis and tendonitis.
• Used to improve mobility and reduce stiffness in affected joints.

In the case of an overdose of Piroxicam 20mg injection, urgent medical attention is required. Symptoms may include severe stomach pain, nausea, and vomiting. It is important to seek emergency medical help and inform the healthcare provider about the suspected overdose. Quick action can help manage potential complications and ensure appropriate treatment is provided to mitigate the effects of the overdose. Prompt medical intervention is crucial for the best possible outcome.

In the case of a missed dose of Piroxicam 20mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume the medication and ensure optimal treatment. It is recommended to set reminders to help you remember your medication schedule.

To administer Piroxicam 20mg injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the medication into the muscle, ensuring the entire dose is delivered as directed by your healthcare provider.

Following are the conditions when Piroxicam 20mg injection should not be used:

• Should not be used in individuals with a known allergy to Piroxicam or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Contraindicated in patients with active gastrointestinal bleeding or a history of gastrointestinal bleeding.
• Not suitable for individuals with a history of severe allergic reactions, such as anaphylaxis.
• Should not be used in patients with severe heart failure or uncontrolled hypertension.
• Contraindicated in individuals with severe kidney disease or active kidney problems.
• Not recommended for patients who have recently undergone coronary artery bypass graft (CABG) surgery.
• Should not be used in patients with a history of bleeding disorders or those on anticoagulant therapy.
• Contraindicated during the last trimester of pregnancy due to potential fetal risks.
• Not suitable for individuals with severe dehydration or low fluid volume in the body.

The side effects of Piroxicam 20mg injection may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Dizziness or a spinning sensation
• Headache
• Skin rash or itching
• Increased blood pressure
• Kidney problems

Following are the precautions and warnings for Piroxicam 20mg injection:

• Not recommended for individuals with known allergies to Piroxicam or other NSAIDs.
• Patients with a history of gastrointestinal bleeding, ulcers, or asthma should use with caution and under medical supervision.
• Kidney function should be monitored during long-term use, especially in elderly patients.
• May increase the risk of cardiovascular events; patients with cardiovascular disease should be closely monitored.
• Avoid using during pregnancy, especially in the third trimester, and consult a doctor if breastfeeding.
• This medication may cause dizziness or drowsiness, so avoid driving or operating machinery until you know how it affects you.
• Piroxicam injection should be administered by trained medical professionals in a clinical setting.

Following are the drug interactions for Piroxicam 20mg injection:

• Aspirin and other NSAIDs (e.g., ibuprofen, naproxen) may increase the risk of gastrointestinal bleeding and ulcers when used concurrently with Piroxicam.
• Piroxicam can decrease the effectiveness of diuretics and antihypertensive medications, potentially reducing their blood pressure-lowering effects.
• When combined with lithium, Piroxicam may increase lithium levels in the blood, leading to lithium toxicity.
• ACE inhibitors (e.g., lisinopril, enalapril) may have their antihypertensive effect diminished by Piroxicam.
• Piroxicam may enhance the anticoagulant effects of warfarin, increasing the risk of bleeding.
• The combination of Piroxicam and cyclosporine may lead to increased toxicity of cyclosporine.
• Corticosteroids may increase the risk of gastrointestinal side effects when used with Piroxicam.

Following are the food interactions for Piroxicam 20mg injection:

• Avoid excessive salt or sodium intake, as Piroxicam can cause sodium and water retention, leading to increased blood pressure.
• Limit alcohol consumption as it may increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Piroxicam, potentially altering its effectiveness.
• Avoid high-fat meals as they can delay the absorption and peak concentration of Piroxicam.
• Foods rich in vitamin K, like leafy green vegetables, should be consumed consistently as Piroxicam can interfere with blood clotting.
• Maintain a balanced diet, as Piroxicam may mask the symptoms of gastrointestinal issues, making it harder to detect dietary problems.
• Avoid caffeine or reduce intake as it can increase the risk of stomach irritation and may interfere with Piroxicam's effectiveness.

Piroxicam 20mg injection should be stored in a controlled environment, specifically at room temperature between 20-25°C (68-77°F). Protect the injection from light and moisture by keeping it in its original packaging until use. Avoid storing it in the bathroom or kitchen, as these areas may expose the medication to heat and humidity. Always check the expiration date before administration and do not use if the solution appears discolored or contains particles. When disposing of unused or expired injections, do not throw them into the trash or pour them down the drain. Contact your healthcare provider or pharmacist for instructions on safe disposal methods to protect the environment and prevent misuse. Keep the medication out of children's reach to ensure their safety.

Following are the quick tips for Piroxicam 20mg injection:

• Administer the injection under the supervision of a trained healthcare professional.
• Ensure the injection is given at the correct site and with proper technique.
• Inform your doctor if you have any allergies or medical conditions before receiving the injection.
• Do not inject if the solution is cloudy or contains particles.
• Report any unusual pain, swelling, or redness at the injection site to your healthcare provider.
• Avoid driving or operating machinery if you experience dizziness or drowsiness after the injection.
• Store the injection as directed, away from direct sunlight and extreme temperatures.
• Do not reuse needles or syringes; dispose of them safely after use.