Peflox (400mg) 10 Tablets

Pefloxacin is a fluoroquinolone antibiotic that exerts its bactericidal effect by inhibiting DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, and repair. It primarily targets these enzymes in bacterial cells, leading to the disruption of DNA synthesis and ultimately causing bacterial cell death. The mechanism involves the binding of pefloxacin to these enzymes, preventing them from unwinding and supercoiling DNA, which is necessary for the normal functioning of bacterial DNA metabolism. This interference with vital DNA processes leads to the rapid bactericidal effect of pefloxacin against susceptible bacteria.

Fluoroquinolone antibiotic.

Tablet

The following are the uses of pefloxacin Tablet:

• Used for treating bacterial infections, particularly effective against a range of gram-negative and some gram-positive bacteria.
• Used for respiratory tract infections like pneumonia and bronchitis.
• Used for urinary tract infections, providing relief and preventing complications.
• Used for skin and soft tissue infections, promoting healing and reducing inflammation.
• Used for bone and joint infections, ensuring proper treatment and recovery.
• Used for gastrointestinal infections, helping manage symptoms and restore digestive health.
• Used for certain sexually transmitted infections, offering a targeted approach to treatment.
• Used as an alternative for patients allergic to other antibiotics, providing a crucial treatment option.

In the case of an overdose of Pefloxacin tablets, individuals may experience severe gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Central nervous system effects like dizziness, confusion, and seizures can also occur. It is crucial to promptly seek medical assistance and provide healthcare professionals with detailed information regarding the quantity ingested. They will then determine the appropriate treatment, which may include gastric lavage, supportive care, and monitoring of vital signs to manage the overdose effectively.

In the case of a missed dose of pefloxacin tablets, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your medication schedule and ensure you're taking the correct amount of medication.

To take Pefloxacin Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when pefloxacin Tablet should not be used:

• Do not take if you have a known allergy to pefloxacin or other quinolone antibiotics.
• Contraindicated in patients with a history of seizures or epilepsy.
• Should not be used in individuals with myasthenia gravis.
• Not suitable for patients with a history of tendon disorders or tendon rupture.
• Avoid if you have severe kidney or liver disease.
• Do not administer to children or adolescents.
• Contraindicated in pregnant or breastfeeding women.
• Should not be used in patients with a history of cardiovascular disease or QT prolongation.
• Avoid if you have central nervous system disorders or psychotic reactions.

The side effects of pefloxacin Tablet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Dizziness
• Headache
• Skin rash or itching
• Sensitivity to sunlight (photosensitivity)
• Nervousness or anxiety

Following are the precautions and warnings for Pefloxacin Tablet:

• Pefloxacin should not be used in patients with a known hypersensitivity or allergy to the drug or other quinolone antibiotics.
• It is important to complete the full course of treatment as prescribed, even if symptoms improve before completion.
• Pefloxacin may cause central nervous system effects like dizziness, headache, and lightheadedness. Patients should exercise caution when performing tasks requiring alertness.
• Patients with a history of seizures or conditions that increase the risk of seizures should use this medication with caution as it may lower the seizure threshold.
• Pefloxacin can cause tendonitis or even tendon rupture, especially in patients over 60 years old, those taking corticosteroids, or those with kidney, heart, or lung transplants.
• Elderly patients and those with kidney or liver disease may require dosage adjustments due to the increased risk of side effects.
• This medication should be used with caution in patients with myasthenia gravis as it may exacerbate muscle weakness.
• Pregnant and breastfeeding women should consult their doctor before taking Pefloxacin as it may cause harm to the fetus or infant.

Following are the drug interactions for pefloxacin Tablet:

• Antacids containing aluminum, magnesium, or calcium can reduce the absorption of pefloxacin, so they should be taken at least 2 hours apart.
• Pefloxacin may enhance the effects of oral anticoagulants like warfarin, requiring close monitoring of coagulation parameters.
• Theophylline levels can be increased by pefloxacin, potentially leading to toxicity.
• Pefloxacin may interact with cyclosporine, increasing its blood levels and the risk of cyclosporine-related side effects.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) might increase the risk of seizures when used with pefloxacin.
• Probenecid can increase pefloxacin blood levels, which may enhance its effects and side effects.
• Pefloxacin may interfere with the effectiveness of live typhoid vaccines.

Following are the food interactions for Pefloxacin Tablet:

• Avoid consuming dairy products like milk, cheese, or yogurt within 2 hours before or after taking Pefloxacin, as calcium can bind to the antibiotic and reduce its absorption.
• High-iron foods such as red meat, liver, and iron-fortified cereals should be consumed a few hours apart from taking Pefloxacin to prevent decreased absorption of the medication.
• Antacids containing magnesium, aluminum, or calcium should be taken at least 2 hours apart from Pefloxacin to avoid reducing its effectiveness.
• Avoid caffeine or limit its consumption while on Pefloxacin, as it can increase the risk of central nervous system side effects.
• Grapefruit and grapefruit juice are to be avoided as they can increase Pefloxacin levels in the blood, potentially leading to an increased risk of side effects.
• Alcoholic beverages should be avoided as they can increase the risk of central nervous system side effects and may also reduce the effectiveness of Pefloxacin.
• Ensure adequate fluid intake and stay well-hydrated while taking Pefloxacin to reduce the risk of certain side effects.
• Pefloxacin should be taken on an empty stomach for optimal absorption, at least one hour before or two hours after a meal.

Pefloxacin Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and effectiveness. It is crucial not to expose the medication to heat or direct sunlight, as it can degrade its quality. Always check the expiration date, and if the tablets have passed their expiry, do not use them and dispose of them appropriately. Avoid flushing or pouring the medication down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods to protect the environment. Keep the medication out of children's reach to prevent accidental consumption, ensuring their safety.

Following are the quick tips for Pefloxacin Tablet:

• Take the tablet as directed by your doctor, typically once or twice a day as prescribed.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Take the tablet on an empty stomach, preferably 1 hour before or 2 hours after meals.
• Avoid taking pefloxacin with dairy products, antacids, or iron supplements as they may interfere with absorption.
• Complete the full course of medication, even if you feel better, to ensure the infection is completely treated.
• Store the tablets at room temperature, away from moisture and light.
• Inform your doctor about all other medications you are taking to prevent potential drug interactions.