Pelton V (12.72mg) 50 Tablets

Domperidone maleate, a peripheral dopamine receptor antagonist, exerts its primary mechanism of action by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) and upper gastrointestinal tract. This blockage inhibits dopamine-induced nausea and vomiting by reducing gastrointestinal motility and enhancing gastric emptying. Domperidone selectively targets peripheral dopamine receptors, particularly D2 receptors, which leads to increased gastrointestinal motility and improved gastrointestinal symptoms.

Domperidone maleate

Antiemetic, prokinetic.

Tablet

The following are the uses of Domperidone maleate Tablet:

• Used for treating nausea and vomiting.
• Used to relieve symptoms of gastrointestinal disorders like reflux and indigestion.
• Used for improving gastrointestinal motility and reducing stomach discomfort.
• Used as a galactagogue to support breastfeeding by increasing milk production.
• Used to manage migraine-related nausea and vomiting.
• Used in the treatment of Parkinson's disease to control symptoms.
• Used to prevent side effects of certain medications, such as nausea and loss of appetite.
• Used to alleviate symptoms of functional dyspepsia.

Follow these dosage instructions:

• Take as per doctor's Prescription.
• Take one tablet per day as your doctor suggests.
• Your doctor will determine the treatment length based on your symptom severity.

In the case of an overdose of Domperidone maleate tablets, individuals may experience a range of symptoms. These can include nausea, vomiting, abdominal pain, and in severe cases, cardiac arrhythmias and seizures. It is important to recognize that an overdose can lead to serious complications, particularly in the central nervous system and the heart. Immediate medical intervention is necessary to manage these symptoms and prevent potential long-term effects on the body's vital functions.

In the case of a missed dose of Domperidone maleate Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, it's best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you frequently miss doses, consider setting reminders or alarms to help you stay on track with your medication regimen. Consult your healthcare professional if you have any concerns or questions regarding missed doses.

To take Domperidone maleate tablets, swallow the prescribed number of tablets whole with a glass of water, as directed by your healthcare professional, usually 15 to 30 minutes before meals and at bedtime, or as instructed on the medication label.

Following are the conditions or situations when Domperidone maleate Tablet should not be used:

• Do not take if you are allergic to Domperidone or any similar medications.
• Contraindicated in individuals with a known or suspected gastric hemorrhage or perforation.
• Should not be used in patients with a history of seizures or epilepsy.
• Not recommended for those with kidney or liver impairment.
• Avoid using if you have a blockage in your intestines or a narrowing of the stomach outlet.
• Contraindicated in patients with an abnormal heart rhythm or a history of heart disease.
• Do not use if you have a pituitary tumor that can produce prolactin.
• Should not be administered to infants or young children, especially for treating reflux.

The side effects of Domperidone maleate Tablet may include:

• Dry mouth
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Fatigue
• Skin rashes
• Irregular heart rhythm

Following are the precautions and warnings for Domperidone maleate Tablet:

• Do not take this medication if you are allergic to Domperidone or any other similar medications.
• This drug is not recommended for those with a history of heart problems, as it may cause irregular heartbeats.
• Caution is advised in patients with liver or kidney disease, as the dosage may need adjustment.
• Elderly patients may be more sensitive to the side effects, especially neurological and cardiac effects.
• Domperidone can cause drowsiness; avoid driving or operating machinery until you know how it affects you.
• Do not consume alcohol while taking this medication as it may increase the risk of side effects.
• Inform your doctor if you have a history of gastrointestinal problems, as it may worsen certain conditions.

Following are the drug interactions for Domperidone maleate Tablet:

• Concomitant use with strong CYP3A4 inhibitors like ketoconazole, clarithromycin, or ritonavir can increase domperidone levels, potentially leading to QT prolongation and arrhythmias.
• Domperidone may interact with macrolide antibiotics such as erythromycin, increasing the risk of cardiac side effects. Close monitoring is necessary.
• Caution is advised when using with other dopamine antagonists, as it may enhance the effects and increase the risk of extrapyramidal symptoms.
• The absorption of domperidone can be decreased by antacids containing aluminum or magnesium; separate administration is recommended.
• Domperidone may increase the oral bioavailability of certain drugs, including some antibiotics and antifungals, potentially leading to higher drug concentrations.
• Concomitant use with digoxin may increase digoxin levels, requiring monitoring and dose adjustments if necessary.
• The effectiveness of domperidone may be reduced when used with opioid analgesics, requiring careful observation for gastrointestinal symptoms.

Following are the food interactions for Domperidone maleate Tablet:

• Avoid grapefruit and grapefruit juice as they can significantly increase Domperidone levels in the blood by inhibiting the enzyme CYP3A4, leading to potential cardiac side effects.
• Alcohol consumption should be avoided as it may enhance the sedative effects of Domperidone, increasing the risk of dizziness and drowsiness.
• Caffeine-containing beverages should be limited as they may decrease the absorption of Domperidone, reducing its effectiveness.
• High-fat meals can delay the absorption of Domperidone, potentially affecting its onset of action.
• Spicy foods may increase stomach acid production, which could potentially reduce the effectiveness of Domperidone in managing gastrointestinal issues.
• Dairy products should be consumed with caution as they may form insoluble complexes with Domperidone, reducing its bioavailability.
• Avoid consuming large amounts of chocolate as it contains compounds that can inhibit the metabolism of Domperidone, potentially leading to increased side effects.
• Always consult your healthcare provider for specific dietary instructions while taking Domperidone to ensure optimal therapeutic outcomes.

Domperidone maleate tablets should be stored in a cool, dry location, ideally at room temperature, and shielded from direct sunlight and moisture. To maintain its integrity and prevent contamination, it is crucial to keep the medication securely sealed in its original packaging. Steer clear of storing it in areas like the bathroom or near heat sources, as temperature fluctuations can impact its effectiveness. Always verify the expiration date on the packaging, and if the tablets are no longer needed or have expired, dispose of them properly. Do not dispose of them by flushing or pouring them down the drain; instead, consult your pharmacist or healthcare provider for appropriate disposal guidelines. It is imperative to keep all medications out of children's reach to prevent accidental consumption.

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Following are the quick tips for Domperidone maleate Tablet:

• Ensure you take the tablet as directed by your doctor or pharmacist.
• Swallow the tablet whole with a full glass of water; do not crush or chew it.
• Domperidone is best taken 30 minutes before meals to maximize its effectiveness.
• If you experience side effects like dizziness, try taking the tablet at bedtime to minimize these effects.
• Avoid alcohol consumption while taking this medication as it may increase the risk of side effects.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Always inform your healthcare provider about all medications you are taking to ensure safe and effective treatment.