Penro (500mg) 1 Vial Injection

Meropenem 500mg injection, a potent broad-spectrum antibiotic, exerts its bactericidal effect by selectively interfering with bacterial cell wall synthesis. It binds to specific penicillin-binding proteins (PBPs), inhibiting the cross-linking of peptidoglycan strands, which ultimately leads to cell lysis and death. Meropenem is particularly effective against a wide range of Gram-positive and Gram-negative bacteria, including those producing extended-spectrum beta-lactamases, by maintaining its affinity for these modified PBPs. This mechanism ensures that Meropenem can effectively combat a variety of bacterial infections, making it a valuable therapeutic option in clinical settings.

Carbapenem antibiotic

injection

The following are the uses of Meropenem 500mg injection:

• Used for treating severe infections caused by multiple-drug resistant bacteria.
• Used for controlling infections in patients with weakened immune systems.
• Used for treating complicated skin and soft tissue infections.
• Used for managing hospital-acquired pneumonia and ventilator-associated pneumonia.
• Used for treating intra-abdominal infections, particularly post-surgical infections.
• Used for controlling bacterial meningitis in severe cases.
• Used for treating complicated urinary tract infections.
• Used as an alternative for patients allergic to penicillin-derived antibiotics.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Urinary Tract Infection (UTI)- Adults • 500 mg intravenously (IV) every 8 hours for 3 days.
• Skin and Skin Structure Infection (SSSI)- Adults • 500 mg IV every 8 hours for 7-14 days.
• Bacterial Meningitis- Adults • 1,000 mg IV every 8 hours. Some patients may require higher doses, up to 2,000 mg IV every 8 hours. Treatment should continue for at least 7 days and may be continued for a longer period depending on patient response and tolerance.
• Hospital-Acquired Pneumonia (HAP), Community-Acquired Pneumonia (CAP), and Lung Abscess- Adults • 500 mg IV every 6 hours for 7-14 days. Treatment may be continued for longer periods in severe cases.

In the case of an overdose of Meropenem 500mg injection, it is important to recognize the potential severity of this situation. Symptoms may include severe nausea, vomiting, diarrhea, and in extreme cases, seizures or neurological issues. Immediate medical intervention is necessary, and patients should be closely monitored for any adverse reactions. The healthcare provider should be contacted right away for guidance on managing the overdose, as they may recommend specific treatments or interventions to mitigate the risks associated with excessive Meropenem administration.

In the case of a missed dose of Meropenem 500mg injection, it is important to administer the missed dose as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. For optimal effectiveness, it is best to take the missed dose within a few hours of the intended time. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To administer Meropenem 500mg injection, reconstitute the powder with the provided sterile water, gently swirl to dissolve, and inject the entire contents intravenously or intramuscularly over approximately 3-5 minutes, following the prescribed dosage and administration instructions provided by your healthcare professional.

Here are the conditions and situations when Meropenem 500mg injection should not be administered:

• Should not be used in patients with a known allergy or hypersensitivity to Meropenem or other carbapenem antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to any beta-lactam antibiotics (such as penicillins or cephalosporins).
• Not recommended for individuals with epilepsy or other seizure disorders, as it may lower the seizure threshold.
• Should be avoided in patients with a history of severe or life-threatening diarrhea caused by antibiotic use, especially Clostridium difficile-associated diarrhea.
• Not suitable for patients with severe kidney impairment without adjusting the dose or frequency of administration.
• Should be used with caution in individuals with a history of neurological disorders, as it may rarely cause neurological side effects.
• Contraindicated in patients with a known or suspected infection caused by bacteria resistant to Meropenem.
• Not recommended for prolonged use without regular monitoring of kidney and liver function.
• Should be avoided in patients with a history of severe gastrointestinal diseases, such as colitis, as it may exacerbate these conditions.

The side effects of Meropenem 500mg injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Headache
• Dizziness
• Injection site reactions (pain, swelling, or redness)
• Seizures (in rare cases)
• Changes in liver function tests

Here are the precautions and warnings for Meropenem 500mg injection:

• Meropenem should be administered with caution to individuals with a history of allergic reactions to other beta-lactam antibiotics, as cross-reactivity may occur.
• Regular monitoring of kidney function is essential during prolonged treatment, especially in patients with pre-existing kidney issues.
• Not recommended for use in patients with severe kidney impairment; dosage adjustments are necessary in patients with mild to moderate kidney problems.
• May cause seizures, especially in patients with central nervous system disorders or on concurrent medications that lower the seizure threshold.
• Caution is advised for patients with a history of gastrointestinal issues, particularly colitis, as it may exacerbate these conditions.
• Should not be used to treat viral infections, as it is ineffective against viruses.
• Elderly patients may require dosage adjustments due to age-related kidney function decline.
• Always inform your healthcare provider about your medical history and any medications you are currently taking to ensure safe use.

Following are the drug interactions for Meropenem 500mg Injection:

• Probenecid can reduce the renal excretion of meropenem, leading to increased levels of the antibiotic.
• Concomitant use with valproic acid may increase the risk of seizures.
• Meropenem may reduce the effectiveness of oral contraceptives, so alternative contraceptive methods are recommended.
• The potential for neurotoxicity may increase when administered with other medications that have similar effects, such as other antibiotics or muscle relaxants.
• It can decrease the efficacy of certain live-attenuated vaccines (e.g., oral polio, rotavirus) if administered concurrently.
• When combined with certain diuretics, such as furosemide, the risk of hearing impairment may be elevated.
• Meropenem may reduce the plasma concentrations of 4-hydroxy carbamazepine, a metabolite of carbamazepine, potentially reducing its effectiveness.

Following are the food interactions to be aware of with Meropenem 500mg injection:

• Avoid consuming alcohol during the treatment period as it may reduce the effectiveness of the medication and increase the risk of side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Meropenem, potentially altering its effectiveness.
• High-fat meals may slightly delay the absorption of Meropenem, but this effect is not considered clinically significant.
• Avoid consuming large amounts of caffeine-containing products as it may increase the risk of seizures, especially in susceptible individuals.
• No specific dietary restrictions are necessary, but maintaining a balanced diet is advisable to support overall health during treatment.
• Avoid natural licorice as it may interact with Meropenem, potentially affecting blood pressure and electrolyte balance.
• Always inform your healthcare provider about your dietary habits to ensure the medication's effectiveness and safety.
• Follow the advice of your healthcare professional regarding any specific dietary considerations while using this medication.

Meropenem 500mg injection should be stored in a controlled environment, specifically at room temperature between 20-25°C (68-77°F), ensuring it is protected from light and moisture. It is crucial to keep the injection in its original packaging to maintain its integrity and sterility. Avoid exposing it to extreme temperatures, including freezing or excessive heat, as it may compromise the medication's effectiveness. Proper disposal of Meropenem injection is essential; do not dispose of it via household waste or sewage systems. Instead, utilize designated medication disposal programs or consult healthcare professionals for guidance on safe disposal methods. Keep this medication securely stored, out of the reach of children and pets, to prevent accidental exposure or ingestion.

Following are the quick tips for Meropenem 500mg Injection:

• Administer the injection under medical supervision as directed by your healthcare professional.
• Ensure proper dosage and duration as prescribed for effective treatment.
• Meropenem is typically given by intravenous infusion, so follow the infusion guidelines carefully.
• Report any allergic reactions or severe side effects immediately to your doctor.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Do not use if the solution appears discolored or contains particles.
• Dispose of used needles and syringes safely to prevent injuries and infections.

Meropenem 500mg is a prescription drug used to treat serious bacterial infections and requires lab tests for monitoring purposes. The lab tests that are ordered by a physician depend on various factors such as the patient's underlying health conditions, the severity of the infection, and the overall clinical situation. It is crucial to monitor closely and evaluate the patient's response to the medication, as well as to adjust the treatment plan accordingly. When treating infections, particularly those resistant to carbapenem, medical professionals often monitor the patient's White Blood Cell Count (WBC). This test is important because it helps determine the body's ability to fight infections. Low WBC results may indicate that the body is struggling to combat the infection, which may be a concern. Additionally, kidney function tests, namely Blood Urea Nitrogen (BUN) and creatinine, are often ordered to assess kidney function, as Meropenem is eliminated from the body through the kidneys. Furthermore, blood chemistry panels to assess the levels of potassium, sodium, calcium, magnesium, and liver function are also important to ensure that the drug is not causing any harm to other organs or systems in the body. For localized infections, such as abscesses or cellulitis, physicians may order additional imaging studies or diagnostic tests to determine the extent of the infection, monitor response to treatment, and determine if surgical intervention is necessary. These tests help provide valuable information at each stage of the patient's treatment and overall health. It is important to note that the healthcare professional overseeing the patient's treatment with Meropenem 500mg will determine which lab tests are appropriate based on the individual's specific situation. It is advised that if you have concerns or questions about your lab tests while taking Meropenem 500mg, you should consult your physician or pharmacist.