Pentasa (500Mg) 100S Tab

Mesalazine 500mg Tablet primarily exerts its therapeutic effects through its active metabolite, 5-aminosalicylic acid (5-ASA), which is released upon reaching the intestinal lumen. 5-ASA inhibits the cyclooxygenase (COX) enzyme, thereby reducing the production of pro-inflammatory prostaglandins and thromboxanes. This anti-inflammatory action helps to decrease inflammation in the gastrointestinal tract. Additionally, Mesalazine and its metabolites may directly scavenge free radicals, inhibit the activation of nuclear factor-kappa B (NF-κB), and modulate the expression of various cytokines and adhesion molecules, all of which contribute to its overall mechanism in reducing inflammation and promoting mucosal healing.

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Mesalazine

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Anti-inflammatory, Mesalamine Derivative.

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Tablet

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The following are the uses of Mesalazine 500mg Tablet:

• Used for treating ulcerative colitis, reducing inflammation in the colon and rectum.
• Used for managing Crohn's disease symptoms, helping to control inflammation.
• Used for maintaining remission in inflammatory bowel diseases, preventing flare-ups.
• Used for relieving abdominal pain and discomfort associated with bowel inflammation.
• Used for promoting healing of intestinal ulcers and lesions.
• Used for reducing diarrhea and rectal bleeding caused by bowel inflammation.
• Used for improving overall quality of life in patients with inflammatory bowel conditions.

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In the case of an overdose of Mesalazine 500mg Tablets, it is important to recognize the potential risks and take appropriate action. Symptoms may include nausea, vomiting, abdominal pain, and in severe cases, kidney problems or blood disorders. If you suspect an overdose, seek medical advice promptly. Treatment options could involve supportive care, monitoring of vital signs, and potential interventions to address any complications that arise from the excessive dosage.

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In the case of a missed dose of Mesalazine 500mg Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is recommended to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen.

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To take the Mesalazine 500mg Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, as directed by your healthcare professional, usually 2 to 4 times a day.

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Following are the conditions when Mesalazine 500mg Tablet should not be taken:

• Should not be used in individuals with a known allergy or hypersensitivity to Mesalazine or any of its inactive ingredients.
• Not suitable for individuals with severe kidney disease or impairment.
• Contraindicated in patients with a history of pancreatitis.
• Should not be used if you have a blockage or obstruction in your intestines.
• Not recommended for children under 2 years of age.
• Avoid using Mesalazine if you have a rare hereditary problem of fructose intolerance.

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The side effects of Mesalazine 500mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Skin rashes
• Hair loss

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Following are the precautions and warnings for Mesalazine 500mg Tablet:

• Do not take this medication if you have a known allergy to Mesalazine or related compounds.
• Patients with kidney or liver disease should exercise caution and consult a healthcare professional before use, as dosage adjustments may be necessary.
• This medication may cause dizziness, so avoid driving or operating heavy machinery until you know how it affects you.
• Inform your doctor if you have a history of lung diseases, as Mesalazine may cause respiratory issues in rare cases.
• Avoid alcohol consumption while taking this medication, as it may increase the risk of side effects.
• If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking Mesalazine.
• Mesalazine should be used with caution in elderly patients, as they may be more susceptible to its side effects.

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Following are the drug interactions for Mesalazine 500mg Tablet:

• Concurrent use with anticoagulants like warfarin may increase the risk of bleeding, and regular monitoring of blood clotting times is necessary.
• Mesalazine can decrease the effectiveness of certain anti-seizure medications, including phenytoin and carbamazepine.
• It may also reduce the efficacy of azathioprine and mercaptopurine, requiring close monitoring of blood cell counts.
• Taking Mesalazine with other drugs that suppress the immune system, such as cyclosporine, can increase the risk of infections.
• The effect of diuretics may be reduced when used with Mesalazine, potentially affecting blood pressure control.
• Combining with other nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of kidney problems and gastrointestinal bleeding.
• Mesalazine may alter the metabolism of certain medications, including some diabetes drugs, requiring dose adjustments.

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Following are the food interactions for Mesalazine 500mg Tablet:

• Alcohol consumption should be avoided as it can irritate the digestive tract and potentially reduce the effectiveness of Mesalazine.
• Maintain a balanced diet with adequate fiber to support digestive health. High-fiber foods like whole grains, fruits, and vegetables can aid in managing digestive issues.
• Avoid spicy and fatty foods as they may aggravate gastrointestinal symptoms and potentially interfere with the medication's absorption.
• Consume a diet rich in antioxidants, including colorful fruits and vegetables, to support overall gut health and reduce inflammation.
• Stay hydrated by drinking plenty of water to aid in digestion and prevent constipation.
• Avoid grapefruit and grapefruit juice as they can interfere with the metabolism of Mesalazine, potentially leading to increased side effects.
• Consult your healthcare provider for personalized dietary recommendations, especially if you have specific dietary restrictions or conditions.
• There are no direct food interactions that affect the absorption of Mesalazine, but maintaining a healthy diet is essential for managing inflammatory bowel conditions.

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Mesalazine 500mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature, away from direct sunlight, moisture, and heat sources like ovens or radiators. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity and prevent contamination. It is crucial to regularly check the expiration date, and if the tablets are expired or no longer needed, they should be disposed of carefully. Do not dispose of them in household garbage, toilets, or sinks; instead, consult your pharmacist or healthcare professional for guidance on proper disposal methods to protect the environment and public health. Always keep medications out of children's reach to prevent accidental consumption.

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Following are the quick tips for Mesalazine 500mg Tablet:

• Take the tablet as directed by your doctor, usually 2-4 times a day.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• You can take it with or without food, but taking it with food may reduce stomach upset.
• Maintain a consistent schedule for taking the medication for better effectiveness.
• If you miss a dose, take it as soon as you remember, unless it's almost time for the next dose.
• Avoid doubling the dose to catch up, as it may increase side effects.
• Store the tablets at room temperature, away from moisture and heat.

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