PEPTO BISMOL SYP8FL(236ML) (L)

Bismuth syrup or suspension acts primarily through the release of bismuth ions, which have several mechanisms of action. It exhibits antimicrobial properties by interfering with the metabolism and growth of bacteria, particularly Helicobacter pylori, a common cause of gastrointestinal infections. Bismuth ions can bind to bacterial cell walls, disrupt their integrity, and inhibit bacterial adhesion to the gastrointestinal mucosa. This action helps prevent bacterial colonization and reduces the production of harmful bacterial byproducts. Additionally, bismuth can neutralize gastric acid, which creates an environment less favorable for bacterial survival and proliferation. It also possesses anti-inflammatory effects, reducing inflammation in the gastrointestinal tract and promoting healing. The mechanism of action contributes to the overall effectiveness of bismuth syrup/suspension in treating gastrointestinal disorders associated with bacterial infections.

Bismuth

Antidiarrheal.

Suspension

The following are the uses of Bismuth Syrup/Suspension:

• Used for treating gastrointestinal disorders, particularly diarrhea and gastrointestinal inflammation.
• Used for its astringent properties to relieve symptoms like nausea and indigestion.
• Used for coating and protecting the gastrointestinal tract, especially in cases of stomach ulcers.
• Used for reducing the duration and severity of stomach flu and other gastrointestinal infections.
• Used for alleviating symptoms of irritable bowel syndrome (IBS) and restoring bowel regularity.
• Used for its soothing effect on the stomach and intestines, providing relief from gastrointestinal discomfort.
• Used for aiding in the management of acid reflux and heartburn.

In the case of an overdose of Bismuth Syrup/Suspension, individuals may experience gastrointestinal symptoms such as nausea, vomiting, and diarrhea. These symptoms can be severe and may require medical attention. Other potential effects include skin rashes, difficulty breathing, and changes in blood pressure. Promptly seek medical advice if an overdose is suspected, as treatment may involve managing symptoms and providing supportive care to prevent further complications. It is crucial to follow the recommended dosage to avoid such incidents.

In the case of a missed dose of Bismuth Syrup/Suspension, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent dosing routine, but if you miss multiple doses, consult your healthcare provider for guidance on how to proceed and ensure the best course of action for your specific situation.

To administer Bismuth Syrup/Suspension, shake the bottle vigorously, then accurately measure the prescribed dose using a dosing spoon or oral syringe, and take it orally, following the dosage instructions provided by your healthcare professional, which may include taking it with or without food.

Here are the conditions or situations when Bismuth Syrup/Suspension should not be used:

• Avoid using in patients with a known allergy or hypersensitivity to bismuth or any of the excipients in the syrup/suspension.
• Not suitable for patients with severe kidney disease or those on dialysis.
• Contraindicated in patients with gastrointestinal obstruction or severe constipation.
• Should not be used in patients with a history of black stools or melena (a sign of gastrointestinal bleeding).
• Not recommended for infants under 3 months of age.
• Avoid using in patients with a history of bismuth toxicity or poisoning.
• Contraindicated during an acute abdomen or abdominal pain of unknown origin.
• Should not be used in patients with severe dehydration or those unable to maintain adequate fluid intake.

The side effects of Bismuth Syrup/Suspension may include:

• Darkening of the tongue or stool, which is temporary and harmless.
• Nausea and vomiting.
• Diarrhea or constipation.
• Abdominal pain or cramps.
• Blackening of the inside of the mouth.
• Allergic reactions, such as rash, itching, or swelling.
• In rare cases, it may cause a temporary darkening of the teeth, which can be minimized by brushing and rinsing the mouth after each dose.
• Prolonged use may lead to electrolyte imbalances, especially in patients with kidney problems.

Following are the precautions and warnings for Bismuth Syrup/Suspension:

• Do not use in patients with known hypersensitivity or allergy to bismuth or any other ingredients in the syrup.
• Avoid prolonged use as it may lead to bismuth accumulation and potential toxicity.
• Caution is advised in patients with gastrointestinal disorders, as bismuth can cause darkening of the tongue and stools.
• Patients with renal impairment should use with caution and under medical supervision, as bismuth excretion may be impaired.
• Bismuth syrup should not be used in children without medical advice, and dosage should be carefully determined based on weight.
• Not recommended for long-term use, especially in high doses, as it may lead to neurological side effects.
• Patients with a history of gastrointestinal surgery or those taking other medications should consult a healthcare professional before use.

Following are the drug interactions for Bismuth Syrup/Suspension:

• Bismuth-containing products can interact with medications that affect gastrointestinal motility (e.g., anticholinergics, opioids), potentially altering the absorption and effectiveness of the drugs.
• Bismuth can decrease the absorption of certain antibiotics (e.g., tetracyclines, fluoroquinolones), potentially reducing their efficacy. It is recommended to separate the use of bismuth products and antibiotics by a few hours.
• Concurrent use of bismuth with antacids or medications that affect stomach pH (e.g., proton pump inhibitors, H2 blockers) may reduce the effectiveness of bismuth.
• The combination of bismuth with anticoagulants (e.g., warfarin) should be used cautiously as bismuth may affect platelet aggregation, increasing the risk of bleeding.
• Bismuth-containing products can increase the absorption of certain medications, including some antifungals, leading to increased drug levels and a potential risk of toxicity.
• Caution should be taken when using bismuth products alongside other medications that affect renal function, as bismuth can accumulate in the kidneys and potentially cause renal toxicity.
• Bismuth can interact with medications that cause constipation, such as iron supplements, potentially exacerbating constipation.
• The use of bismuth with alcohol should be avoided as it may increase the risk of gastrointestinal irritation.

Following are the food interactions for Bismuth Syrup/Suspension:

• Bismuth should not be taken with dairy products like milk, cheese, or yogurt as calcium can bind with bismuth and reduce its absorption, decreasing its effectiveness.
• Avoid consuming antacids containing calcium, magnesium, or aluminum simultaneously as Bismuth Syrup, as these minerals can interfere with bismuth absorption.
• Consuming acidic foods like citrus fruits or juices may increase the absorption of bismuth, potentially leading to higher blood levels and increased side effects.
• It is recommended to wait at least 2 hours after taking the bismuth dose before consuming any dairy products to minimize interactions.
• Alcohol consumption should be avoided as it can irritate the stomach lining and may exacerbate gastrointestinal symptoms, especially when combined with Bismuth Syrup.
• High-fat meals can delay the absorption of bismuth, so it is best to take the medication on an empty stomach or with a light meal.
• Certain foods rich in sulfur, such as garlic, onions, and cruciferous vegetables, may increase the formation of bismuth sulfide, which can reduce the effectiveness of the medication.

Bismuth Syrup/Suspension should be stored with caution, preferably in a cool and dry place, maintaining room temperature. Keep the medication in its original container, tightly sealed, to ensure it remains protected from contamination. Avoid exposure to direct sunlight, moisture, or extreme temperatures, as this can impact the medication's effectiveness. Do not store it in bathrooms or near heat sources like radiators or stoves. Always adhere to the expiration date on the packaging, and if the syrup is no longer needed or has expired, do not dispose of it by flushing or pouring down the drain. Consult your pharmacist or healthcare provider for guidance on safe disposal methods. Remember to keep all medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Bismuth Syrup/Suspension:

• Follow the dosage instructions provided by your healthcare professional for accurate results.
• Administer the medication with precision using the measuring device supplied.
• Avoid mixing the syrup with other medications unless advised by your doctor.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Always check the expiration date before using the medication.
• Contact your doctor if symptoms persist or worsen despite treatment.
• Do not share the medication with others, even if they have similar symptoms.