PERGOLIDE 250MCG 100'S

Pergolide, the active ingredient in Pergolide 250 Tablet, acts as a dopamine agonist. Its primary mechanism of action involves binding to dopamine receptors in the brain, specifically D2-type receptors. By activating these receptors, pergolide mimics the effects of dopamine, a neurotransmitter that plays a crucial role in regulating movement and motor control. This activation helps to normalize dopamine signaling, thereby reducing the symptoms associated with dopamine deficiency, such as those observed in Parkinson's disease. Pergolide's ability to stimulate dopamine receptors leads to improved muscle control, reduced tremors, and enhanced overall motor function in patients with Parkinson's disease.

Dopamine agonist.

Tablet

The following are the uses of Pergolide 250 Tablet:

• Used for treating Parkinson's disease to control tremors, stiffness, and difficulty moving.
• Used to manage symptoms of advanced Parkinson's, improving daily living activities.
• Used to reduce "on-off" symptoms, providing more consistent control.
• Used to enhance the effects of Levodopa, a common Parkinson's medication.
• Used for managing prolactin-related conditions in certain cases.
• Used to lower high prolactin levels, which can affect various body functions.
• Used for managing symptoms of advanced Parkinson's, improving overall quality of life.

In the case of an overdose of Pergolide 250 Tablets, it is important to recognize the potential symptoms, which may include severe nausea, dizziness, and hallucinations. The severity of the overdose can vary, so seeking medical assistance promptly is essential. Depending on the amount ingested, immediate healthcare intervention may be required to manage symptoms and prevent potential complications. Timely action can significantly impact the outcome of such incidents.

In the case of a missed dose of Pergolide 250 Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose to avoid an overdose. Do not double the dose to make up for a missed one. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track. It's crucial to maintain consistency in taking your medication as prescribed by your healthcare professional.

To take Pergolide 250 Tablets, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your veterinarian.

Following are the conditions or circumstances when Pergolide 250 Tablet should not be taken:

• Allergy Should not be used if the patient is allergic to Pergolide or any of its inactive ingredients.
• Fibrotic Conditions Contraindicated in patients with retroperitoneal fibrosis, pulmonary fibrosis, or pericardial fibrosis.
• Valvular Heart Disease Not recommended for patients with moderate to severe valvular heart disease.
• Psychotic Disorders Should not be used in individuals with a history of psychotic disorders or severe mental health conditions.
• Pregnancy and Breastfeeding Pergolide is not recommended during pregnancy and breastfeeding due to potential risks to the fetus and infant.
• Kidney or Liver Impairment Not suitable for patients with severe kidney or liver disease.

The side effects of Pergolide 250 Tablet may include:

• Dizziness and lightheadedness
• Nausea and vomiting
• Fatigue and weakness
• Confusion and cognitive impairment
• Hallucinations
• Constipation or diarrhea
• Decreased appetite and weight loss
• Orthostatic hypotension (a sudden drop in blood pressure upon standing)

Following are the precautions and warnings for Pergolide 250 Tablet:

• Pergolide should be used with caution in patients with a history of heart disease, as it may cause changes in blood pressure and heart rate.
• Patients with a history of psychiatric disorders should be closely monitored as it may worsen symptoms.
• Not recommended for individuals with uncontrolled hypertension, as it can lead to further elevation in blood pressure.
• Elderly patients may be more sensitive to the effects of this medication, so dosage adjustments might be necessary.
• Pregnant women should not take this medication as it may cause harm to the fetus.
• Breastfeeding women should exercise caution as pergolide may pass into breast milk and potentially affect the nursing infant.
• This medication may cause drowsiness and dizziness, so patients should avoid driving or operating heavy machinery until they know how it affects them.

Following are the drug interactions for Pergolide 250 Tablet:

• Antipsychotics, such as haloperidol or risperidone, may reduce the effectiveness of pergolide, potentially requiring dose adjustments.
• Pergolide can interact with anti-nausea medications like metoclopramide, leading to decreased pergolide absorption and reduced efficacy.
• Caution is advised when combining pergolide with medications that lower blood pressure, as it may cause excessive hypotension.
• The effectiveness of pergolide may be reduced when taken with certain anti-seizure medications, including carbamazepine and phenytoin.
• Pergolide can interact with ergot alkaloids, increasing the risk of ergotism, a serious condition affecting blood circulation.
• Use with caution alongside drugs affecting liver function, as this may alter pergolide metabolism and increase side effects.
• Pergolide may interact with medications containing alcohol, leading to increased side effects and impaired judgment.

Following are the food interactions for Pergolide 250 Tablet:

• Avoid consuming grapefruit and grapefruit juice as they may interfere with the medication's metabolism, potentially leading to increased drug levels in the blood.
• Alcohol consumption should be limited or avoided as it may enhance the sedative effects of Pergolide, increasing the risk of dizziness and drowsiness.
• High-fat meals may delay the absorption of Pergolide, leading to a potential decrease in its effectiveness.
• Caffeine-rich foods and beverages should be consumed in moderation as they may interact with Pergolide and increase the risk of side effects like nervousness and insomnia.
• Avoid excessive consumption of chocolate, as it contains a small amount of a compound similar to Pergolide, which may lead to an additive effect and potential overdose.
• Pergolide may interact with certain aged cheeses and processed meats containing tyramine, causing a potential increase in blood pressure.
• Some herbal supplements, like St. John's Wort, may reduce the effectiveness of Pergolide by influencing its metabolism.
• Always consult your healthcare provider for specific dietary guidelines and adjustments while taking Pergolide to ensure optimal treatment outcomes.

Pergolide 250 Tablets should be stored in a secure and dry location, preferably at room temperature, ensuring protection from direct sunlight, moisture, and heat. Maintain the tablets in their original packaging, tightly sealed, to preserve their integrity and prevent contamination. It is crucial to regularly check the expiration date on the package and properly dispose of any unused or expired tablets. When disposing of the medication, avoid flushing it down the toilet or pouring it into any water source. Consult your local pharmacist or healthcare professional for guidance on the appropriate disposal methods in your area. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Pergolide 250 Tablet:

• Consult your veterinarian before starting the medication for proper dosage and duration.
• Administer the tablet orally, following your vet's instructions for accurate dosing.
• Give the tablet as a whole; do not crush or break it to ensure proper absorption.
• Create a consistent routine by giving the medication at the same time daily.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your pet's response to the medication and report any concerns to your veterinarian.
• Never adjust the dosage or stop the medication without consulting your veterinarian.