Perilium (10mg) 50 Tablets

Perilium (10mg) 50 Tablets

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  • Manufacturer Adamjee Pharmaceuticals (Pvt.) Ltd.
  • Generic Name

    Domperidone

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • Dosage
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Domperidone is a medication primarily used to treat nausea and vomiting, as well as gastrointestinal disorders like bloating, indigestion, and reflux. It works by blocking dopamine receptors in the gut and the brain, enhancing the motility of the stomach and intestines, thereby improving digestion and preventing the feeling of nausea. Domperidone is also used to alleviate symptoms associated with delayed gastric emptying or gastroparesis. It is typically prescribed for short-term use to manage these symptoms and may be used in combination with other treatments for conditions like Parkinson's disease to help control nausea caused by dopaminergic medications.

  • Ingredients

    Domperidone

  • Drug Class

    dopamine antagonists

  • Dosage Form

    Tablet

  • Uses

    Following are the uses of Domperidone:

    • Used to relieve nausea and vomiting caused by various conditions, including gastrointestinal disorders, medications, or chemotherapy.
    • Helps manage symptoms of gastroparesis, a condition that causes delayed stomach emptying, by improving gastric motility.
    • Effective in treating dyspepsia (indigestion) by relieving bloating and discomfort in the stomach.
    • Can be used to alleviate nausea and vomiting associated with migraines.
    • Helps reduce symptoms of acid reflux and heartburn by promoting faster digestion and stomach emptying.
    • Often prescribed to improve lactation in women by increasing milk production, particularly in breastfeeding mothers with low milk supply.
    • Used to manage symptoms of nausea and vomiting in patients undergoing cancer treatments or surgeries.
    • Provides symptomatic relief from nausea in patients with Parkinson’s disease caused by dopaminergic therapy.
  • Dosage

    Dosage of Domperidone:

    • For adults, the typical dose is 10 mg taken 3 times daily, before meals, or as directed by a healthcare provider.
    • In some cases, the dose may be increased to 20 mg 3 times a day if needed, but should not exceed 80 mg per day.
    • For the treatment of nausea and vomiting, 10 mg is typically administered before meals and at bedtime.
    • For gastroparesis or digestive disorders, 10 mg may be taken before meals to enhance gastric motility.
    • For lactation support, the recommended dosage may vary based on the individual's response, with a typical dose being 10 mg 3 times daily.
    • Domperidone should be taken with a full glass of water and swallowed whole; do not crush or chew the tablets.
  • In case of Overdose

    In case of an overdose of Domperidone, seek immediate medical attention. Symptoms of overdose may include agitation, confusion, rapid heart rate, or abnormal movements. If you suspect an overdose, contact your healthcare provider, local poison control center, or emergency services right away. It is important to avoid self-treatment and allow medical professionals to assess the situation. Treatment may involve supportive care to manage symptoms and prevent further complications. If possible, provide information regarding the amount and timing of the overdose. Always follow the recommended dosage and consult with your healthcare provider if you have any concerns regarding your medication.

  • Missed Dose

    If you miss a dose of Domperidone, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for a missed dose, as this could increase the risk of side effects. If you are unsure about what to do, or if you have missed multiple doses, consult your healthcare provider for guidance. Always follow your healthcare provider’s instructions regarding dosage and timing.

  • How To Use

    Domperidone should be used as prescribed by your healthcare provider. The tablets are typically taken orally, with or without food. It is important to swallow the tablet whole with a glass of water; do not crush or chew it.

  • When Not to Use

    When not to use Domperidone:

    • If you are allergic to domperidone or any of the ingredients in the formulation.
    • In individuals with a history of gastrointestinal bleeding or obstruction, as domperidone may worsen these conditions.
    • Avoid use in patients with severe liver impairment or kidney disease, as domperidone may further harm these organs.
    • Do not use in individuals with a history of heart problems, such as arrhythmias, as domperidone may increase the risk of heart-related complications.
    • If you are pregnant or breastfeeding, as domperidone may pose risks to the fetus or infant.
    • Avoid using domperidone in combination with certain medications, such as those that affect heart rhythm (e.g., certain antifungal or antiarrhythmic drugs).
  • Side Effects

    Side effects of Domperidone include:

    • Drowsiness
    • Headache
    • Dry mouth
    • Diarrhea
    • Abdominal cramps
    • Dizziness
    • Rash
    • QT-prolongation"
  • Precautions & Warnings

    Precautions and Warnings for Domperidone include:

    • Use with caution in individuals with a history of gastrointestinal disorders, as it may exacerbate conditions like bleeding or perforation.
    • If you have a history of cardiovascular issues, such as heart disease or arrhythmias, domperidone should be used cautiously, as it may increase the risk of heart-related side effects.
    • Do not exceed the recommended dosage of domperidone, as high doses may increase the risk of serious side effects, including heart problems like QT prolongation.
    • Individuals with liver or kidney impairment should use domperidone with caution, as these conditions may affect how the drug is processed in the body.
    • Domperidone should not be used in combination with certain drugs that prolong the QT interval or cause electrolyte imbalances, as this could increase the risk of serious heart arrhythmias.
    • If you experience symptoms like dizziness, lightheadedness, or an irregular heartbeat, stop taking domperidone immediately and seek medical attention.
    • Pregnant and breastfeeding women should consult their healthcare provider before using domperidone, as it may not be suitable during pregnancy or lactation.
    • Keep out of reach of children to prevent accidental ingestion, especially in high doses.
  • Drug Interactions

    Drug Interactions for Domperidone include:

    • Domperidone may interact with drugs that prolong the QT interval, such as certain antiarrhythmics, increasing the risk of serious heart rhythm issues.
    • Concurrent use with drugs that affect liver enzymes (CYP3A4 inhibitors like ketoconazole) may increase domperidone levels, potentially leading to toxicity.
    • Combining domperidone with sedatives or other CNS depressants may enhance sedative effects, causing excessive drowsiness or dizziness.
    • Domperidone may interact with anticholinergic drugs, reducing its effectiveness.
    • Use with dopamine agonists may reduce the effectiveness of both drugs.
    • If taking drugs that increase heart rate or alter blood pressure, domperidone may interact by affecting cardiovascular functions.
    • Domperidone may interact with certain antibiotics or antifungals, affecting the metabolism and blood concentration of the drug.
  • Food Interactions

    Food Interactions for Domperidone include:

    • Taking domperidone with a heavy meal may slow its absorption and delay its effect. It is recommended to take it on an empty stomach for faster action.
    • Grapefruit and grapefruit juice should be avoided as they can increase the levels of domperidone in the blood, potentially leading to an increased risk of side effects, particularly those related to heart rhythm.
    • Alcohol consumption should be limited while using domperidone, as alcohol can increase the sedative effects of the drug and cause dizziness, drowsiness, or impaired coordination.
    • High-fat meals may reduce the absorption of domperidone, making it less effective.
  • Storage/Disposal

    Domperidone should be stored in a cool, dry place away from direct sunlight, heat, and moisture, ideally at a temperature below 30°C. Keep the medication out of reach of children and pets to prevent accidental ingestion. Do not use domperidone after the expiration date mentioned on the packaging. Dispose of unused or expired medication responsibly, following local guidelines for medication disposal. Avoid flushing it down the toilet or throwing it in household waste unless instructed to do so by your pharmacist or local waste disposal authority.

  • Quick Tips, if any

    Quick Tips for Domperidone:

    • Take domperidone as prescribed by your healthcare provider; avoid self-adjusting the dosage.
    • It is best taken on an empty stomach to enhance absorption and effectiveness.
    • Avoid alcohol and grapefruit juice while on this medication to reduce the risk of side effects.
    • If you experience any signs of heart irregularities, such as palpitations or fainting, contact your healthcare provider immediately.
    • Follow your healthcare provider's instructions carefully, especially regarding the duration of use, to avoid potential risks such as prolonged QT interval.

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