Persantin (10mg/2ml) 10 Ampoule Injections

Dipyridamole, when administered intravenously at a dose of 10mg, acts by inhibiting the enzyme phosphodiesterase. This inhibition leads to an increase in cyclic adenosine monophosphate (cAMP) levels within platelets and blood vessels. As a result, platelet aggregation and blood viscosity are reduced, and endothelial function is improved. This mechanism contributes to the drug's ability to enhance blood flow, particularly in the coronary arteries, making it useful in certain cardiovascular conditions.

Platelet inhibitor

Injection

The following are the uses of Dipyridamole IV 10mg injection:

• Used for preventing blood clots after heart valve replacement surgery, ensuring a smooth recovery.
• Used to treat blood clots in the lungs (pulmonary embolism), quickly dissolving clots.
• Used for managing atrial fibrillation, helping to regulate irregular heart rhythms.
• Used in stress tests to simulate exercise, aiding in diagnosing heart conditions.
• Used for secondary stroke prevention, reducing the risk of recurrence.
• Used to enhance MRI scans, providing clearer images of blood vessels.
• Used as an alternative to aspirin for patients with heart conditions who cannot tolerate it.

In the case of an overdose of Dipyridamole IV 10mg injection, prompt medical attention is necessary. Symptoms may include severe hypotension, bradycardia, and even heart block. Treatment involves supportive care, monitoring vital signs, and potentially administering intravenous fluids. It is crucial to seek medical assistance immediately to manage any adverse effects and ensure the patient's safety. The healthcare provider should be informed about the overdose to determine the best course of action.

In the case of a missed dose of Dipyridamole IV 10mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one. If you have missed multiple doses, contact your healthcare professional for guidance on how to safely adjust your dosing schedule and ensure the medication's effectiveness. It is crucial to maintain consistency with this medication for optimal therapeutic benefits.

To administer the Dipyridamole IV 10mg injection, prepare the medication by drawing the prescribed dose into a syringe, ensuring the needle is securely attached, then locate a suitable vein, insert the needle at a slight angle, and slowly inject the medication while monitoring for any signs of discomfort or adverse reactions.

Here are the situations when Dipyridamole IV 10mg injection should not be used:

• Should not be administered to patients with known hypersensitivity or allergy to Dipyridamole or any of its excipients.
• Not recommended for patients with severe coronary artery disease or unstable angina.
• Contraindicated in patients with acute myocardial infarction (heart attack).
• Should not be used in patients with severe low blood pressure or hypotension.
• Avoid using in patients with severe liver or kidney disease.
• Not suitable for patients with severe cerebrovascular disease or recent stroke.
• Do not administer to patients with active bleeding or severe bleeding disorders.
• Contraindicated during the acute phase of myocardial infarction or severe heart failure.

The side effects of Dipyridamole IV 10mg injection may include:

• Headache
• Dizziness
• Nausea and vomiting
• Chest pain
• Slow heart rate (bradycardia)
• Hypotension (low blood pressure)
• Skin rash or itching
• Allergic reactions

Here are the precautions and warnings for Dipyridamole IV 10mg injection:

• Do not administer this injection if you are allergic to Dipyridamole or any of its excipients.
• Caution is advised for patients with severe coronary artery disease, as it may lead to myocardial ischemia.
• Dipyridamole should be used with caution in patients with severe liver or kidney disease, as dosage adjustments may be necessary.
• Avoid in patients with acute myocardial infar or acute heart failure, as it may worsen their condition.
• This medication may cause hypotension; monitor blood pressure closely during and after administration.
• Elderly patients may be more susceptible to side effects; careful monitoring is recommended.
• Do not administer Dipyridamole IV if there is active bleeding or a history of bleeding disorders.

Following are the drug interactions for Dipyridamole IV 10mg injection:

• May increase anticoagulant effects of heparin, warfarin, and other oral anticoagulants, requiring close monitoring of coagulation parameters.
• Can reduce the effectiveness of antihypertensives, including beta-blockers and calcium channel blockers, necessitating blood pressure monitoring.
• Concomitant use with antiplatelet agents like aspirin or clopidogrel may increase the risk of bleeding.
• The effects of dipyridamole may be decreased by adenosine, requiring dosage adjustments.
• Theophylline metabolism can be affected, potentially increasing theophylline levels and associated side effects.
• May reduce the effectiveness of anti-diabetic medications, leading to altered blood glucose control.
• Could potentially interact with cytochrome P450 (CYP450) enzyme inducers, affecting drug metabolism.

Following are the food interactions to consider with Dipyridamole IV 10mg injection:

• Avoid consuming alcohol during treatment, as it may increase the risk of bleeding and reduce the medication's effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the medication's metabolism, potentially leading to increased blood levels of Dipyridamole.
• Caffeine-rich foods and beverages, such as coffee, tea, and energy drinks, may need to be limited as they can interact with Dipyridamole and affect blood vessel function.
• Foods high in tyramine, like aged cheeses, cured meats, and certain fermented foods, should be avoided as they can potentially interact with Dipyridamole and increase blood pressure.
• Fatty meals may affect the absorption of Dipyridamole, so it is advisable to follow the healthcare provider's instructions regarding food intake before and after the injection.
• Avoid vitamin E supplements and foods rich in vitamin E, as they can enhance the antiplatelet effect of Dipyridamole.
• Always inform your healthcare provider about your diet and any significant changes to ensure the safe and effective use of Dipyridamole IV injection.

Dipyridamole IV 10mg injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20°C and 25°C (68°F to 77°F). Protect the injection from direct sunlight and avoid exposure to freezing temperatures. Keep the medication in its original packaging, ensuring the vial or ampoule is sealed to maintain sterility. Do not use the injection if the solution appears discolored or contains particles. Dispose of any unused or expired Dipyridamole injection through a medical waste disposal program or as directed by your healthcare facility's guidelines. It is crucial to handle and dispose of injections with care, keeping them out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Dipyridamole IV 10mg injection:

• Administer the injection under medical supervision for safety.
• Ensure the injection is given at the recommended dosage and rate.
• Verify the patient's identity and cross-check the medication before administration.
• Use aseptic techniques to prevent infection.
• Monitor vital signs during and after the injection.
• Report any adverse reactions or unusual symptoms immediately.
• Dispose of sharps and medical waste properly.
• Store the injection as directed on the packaging, away from direct sunlight.