PERSANTIN 25MG TAB

Dipyridamole 25MG Tablet primarily exerts its therapeutic effects through several mechanisms of action. Firstly, it acts as a phosphodiesterase inhibitor, specifically targeting phosphodiesterase enzymes in platelets and vascular endothelial cells. By inhibiting phosphodiesterase, dipyridamole elevates the intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This increase in cAMP and cGMP leads to the inhibition of platelet aggregation and promotes vasodilation by relaxing vascular smooth muscles. Moreover, dipyridamole enhances the production and release of prostacyclin, a potent vasodilator and inhibitor of platelet aggregation, thereby further contributing to its anti-platelet and vasodilatory effects. These mechanisms collectively improve blood flow and exert therapeutic benefits in various cardiovascular conditions.

Antiplatelet

Tablet

The following are the uses of Dipyridamole 25MG Tablet:

• Used for preventing blood clots after heart valve replacement surgery.
• Used to reduce the risk of stroke and heart attack in patients with a history of these conditions.
• Used to improve blood flow in conditions like peripheral artery disease.
• Used for managing chest pain (angina) by improving blood supply to the heart.
• Used as a supplement in certain heart and blood vessel conditions.
• Used to maintain the flow of blood during open-heart surgery.
• Used to prevent blood clots in patients with atrial fibrillation.

In the case of an overdose of Dipyridamole 25MG Tablets, the severity of symptoms can vary depending on the amount ingested. Common effects may include severe headaches, dizziness, and a significant drop in blood pressure, leading to potential fainting or lightheadedness. Overdose can also result in gastrointestinal issues such as nausea, vomiting, and diarrhea. Prompt medical intervention is necessary to manage these symptoms effectively and ensure the patient's well-being.

In the case of a missed dose of Dipyridamole 25MG Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for advice on how to safely adjust your medication schedule. It is important to maintain a consistent dosing routine for the medication's effectiveness.

To take the Dipyridamole 25MG Tablet, swallow the tablet whole with a glass of water, as directed by your doctor, usually four times a day, preferably with or after meals.

Following are the conditions/situations when Dipyridamole 25MG Tablet should not be used:

• Should not be used in patients with a known allergy or hypersensitivity to Dipyridamole or any of its components.
• Contraindicated in individuals with severe liver or kidney disease.
• Not recommended for patients with acute myocardial infarction (heart attack) or unstable angina.
• Should be avoided in individuals with severe low blood pressure or those who have experienced a recent stroke.
• Not suitable for patients with severe coronary artery disease or heart failure.
• Should not be used in patients with a blood disorder called thrombocytopenia.
• Contraindicated during active bleeding or severe bleeding disorders.

The side effects of Dipyridamole 25MG Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea
• Flushing (warmth, redness, or tingling under the skin)
• Chest pain
• Increased heart rate

Following are the precautions and warnings for Dipyridamole 25MG Tablet:

• Not recommended for patients with severe coronary artery disease or those who have recently had a heart attack, as it may cause chest pain or worsen heart conditions.
• Patients with a history of low blood pressure should exercise caution, as Dipyridamole can further lower blood pressure.
• May cause dizziness or lightheadedness, so patients should be cautious when standing up, especially from a lying position.
• Those with liver disease or a history of liver problems should be monitored regularly, as Dipyridamole can affect liver function.
• Elderly patients may be more sensitive to the effects of this medication and should be closely monitored for side effects.
• Not recommended for children unless prescribed by a healthcare professional.
• If you are scheduled for surgery, inform your doctor about Dipyridamole use to prevent potential interactions with anesthesia.
• Always inform your healthcare provider about any other medications or supplements you are taking to avoid potential drug interactions.

Following are the drug interactions for Dipyridamole 25MG Tablet:

• Anticoagulants like warfarin or heparin may have increased effects, leading to excessive bleeding.
• Aspirin, when used with Dipyridamole, can enhance its antiplatelet effects, potentially increasing bleeding risk.
• The effectiveness of certain antihypertensive medications may be reduced, including beta-blockers and ACE inhibitors.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) can further inhibit platelet function, potentially causing bleeding complications.
• Probenecid, a uricosuric agent, may decrease the renal clearance of Dipyridamole, leading to higher plasma levels.
• Dipyridamole may increase the concentration of some medications metabolized by the liver, such as phenytoin and theophylline.
• Caution is advised with drugs that affect liver enzymes, as this may alter Dipyridamole's metabolism and effectiveness.
• Combining with adenosine may prolong the heart-slowing effects of adenosine, requiring dose adjustments.

Following are the food interactions to consider with Dipyridamole 25MG Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may affect the absorption and metabolism of Dipyridamole, potentially leading to increased drug levels in the body.
• Avoid excessive alcohol consumption as it may enhance the blood-thinning effects of Dipyridamole, increasing the risk of bleeding.
• High-fat meals may delay the absorption of Dipyridamole, resulting in a potential reduction in its effectiveness.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks may interact with Dipyridamole, affecting blood vessel dilation and heart rate.
• Avoid consuming large amounts of green leafy vegetables rich in vitamin K (like spinach, kale) as they can counteract the blood-thinning effects of Dipyridamole.
• Fish rich in omega-3 fatty acids, such as salmon and tuna, may enhance the anti-platelet activity of Dipyridamole, increasing the risk of bleeding.
• Consult your healthcare provider about any dietary restrictions or adjustments needed, especially if you have a history of bleeding disorders or gastrointestinal issues.
• Generally, it is advisable to maintain a balanced diet and follow any specific dietary recommendations provided by your healthcare team.

Dipyridamole 25MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Maintain a consistent room temperature, avoiding exposure to direct sunlight, moisture, or extreme heat. It is crucial to keep the tablets in their original packaging or a tightly sealed container to maintain their integrity and prevent degradation. Regularly check the expiration date, and never use the medication beyond this date. When disposing of unused or expired tablets, do not flush them down the toilet or discard them in regular trash. Instead, contact your local pharmacy or healthcare provider for guidance on safe disposal methods to protect the environment and prevent misuse. Ensure that the medication is stored out of children's reach to prevent accidental consumption, which could have serious consequences.

Following are the quick tips for Dipyridamole 25MG Tablet:

• Take the tablet as directed by your doctor, usually 4 times a day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• You can take it with or without food, but maintain consistency.
• Avoid taking antacids within 1 hour before or 2 hours after taking this medicine.
• Inform your doctor if you have any allergies before starting this medication.
• Store at room temperature, away from moisture and light.
• Do not double the dose to make up for a missed one; take it as soon as you remember.