PERSIVA 5MG TAB

Prasugrel is a prodrug that works by irreversibly inhibiting platelet aggregation. Once metabolized in the body, it is converted into its active form, which specifically targets the P2Y12 receptors on platelets. This active metabolite binds to the P2Y12 receptors, leading to a rapid and potent blockade of adenosine diphosphate (ADP)-mediated platelet activation and aggregation. By inhibiting the P2Y12 receptors, prasugrel prevents the binding of ADP, a key component in the process of platelet clumping and clot formation. This mechanism of action effectively reduces the risk of thrombotic events by inhibiting platelet activation and subsequent aggregation at the site of vascular injury.

Thienopyridine antiplatelet agent.

Tablet

The following are the uses of Prasugrel 5MG Tablet:

• Used for preventing blood clots in patients with acute coronary syndrome who undergo angioplasty.
• Used to reduce the risk of heart attacks and strokes in specific cardiovascular conditions.
• Used to inhibit platelet aggregation, preventing the formation of harmful blood clots.
• Used in patients with certain types of heart disease to improve blood flow and prevent complications.
• Used as an antiplatelet agent to maintain open blood vessels and ensure proper circulation.
• Used to manage conditions like unstable angina and heart attacks, promoting better heart health.

In the case of an overdose of Prasugrel 5MG Tablets, it is essential to act promptly. The primary concern is uncontrolled bleeding, as the medication's effect can lead to prolonged bleeding time. If an overdose is suspected, seek medical advice immediately. Do not induce vomiting, as this may worsen the bleeding risk. Medical professionals will manage the overdose by closely monitoring vital signs and may administer platelet transfusions to control bleeding.

In the case of a missed dose of Prasugrel 5MG Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of bleeding. It is crucial to maintain a consistent dosing routine for the medication to be effective, so try to take the tablet at the same time each day. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed.

To take Prasugrel 5MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically taken once daily before a meal.

Here are the conditions and situations when Prasugrel 5MG Tablet should not be used:

• Should not be used in patients with a known allergy or hypersensitivity to Prasugrel or any of its components.
• Contraindicated in individuals with active bleeding or bleeding disorders, such as hemophilia.
• Not recommended for patients with a history of stroke or transient ischemic attack (TIA).
• Should not be used in individuals with severe liver disease or liver impairment.
• Contraindicated in patients with a history of intracranial hemorrhage (bleeding in the brain).
• Not suitable for those with a history of gastrointestinal ulcers or bleeding.
• Should be avoided in patients with severe kidney disease or end-stage renal disease.
• Not recommended for individuals who have recently undergone major surgery, especially brain, spinal, or eye surgery.

The side effects of Prasugrel 5MG Tablet may include:

• Increased bleeding tendency, including prolonged bleeding from wounds, gums, or nosebleeds.
• Headache and dizziness.
• Nausea and vomiting.
• Fatigue and weakness.
• Bruising easily.
• Skin rashes or itching.
• Gastrointestinal discomfort (stomach pain, indigestion).

Following are the precautions and warnings for Prasugrel 5MG Tablet:

• Prasugrel should not be used in patients with active bleeding disorders or a history of stroke, as it can increase the risk of bleeding.
• Patients should inform their doctor about any previous allergic reactions to Prasugrel or related medications.
• Caution is advised for patients with liver or kidney disease, as the medication's effects may be altered.
• Regular monitoring of platelet counts and liver function is recommended during treatment.
• Patients should not abruptly stop taking Prasugrel without consulting their doctor, as it may increase the risk of clotting.
• Prasugrel may interact with other medications, including antiplatelet drugs and anticoagulants, so patients must provide a complete medical history.
• Pregnant and breastfeeding women should consult their doctor before taking Prasugrel, as it may pose risks to the fetus or infant.
• Patients should seek immediate medical attention if they experience any signs of bleeding, such as unusual bruising or prolonged bleeding from cuts.

Following are the drug interactions for Prasugrel 5MG Tablet:

• Prasugrel is an antiplatelet medication, and its effects are increased when taken with other antiplatelet drugs like clopidogrel, ticagrelor, or aspirin, potentially leading to excessive bleeding.
• The use of Prasugrel with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, or celecoxib can further increase the risk of bleeding.
• Prasugrel may reduce the effectiveness of anticoagulants like warfarin, necessitating close monitoring of coagulation parameters.
• Drugs that induce or inhibit cytochrome P450 enzymes, particularly CYP2B6 and CYP3A4, can affect Prasugrel's metabolism, potentially altering its effectiveness.
• Proton pump inhibitors (PPIs) such as omeprazole or pantoprazole may decrease the absorption and antiplatelet effect of Prasugrel, thus reducing its effectiveness.
• Thrombolytic agents, when used with Prasugrel, can significantly increase the risk of bleeding complications.
• Combining Prasugrel with other medications that affect platelet function, such as glycoprotein IIb/IIIa inhibitors, may further enhance its antiplatelet effect.
• Caution is advised when using Prasugrel with herbal supplements that affect platelet aggregation, as this may increase the risk of bleeding.

Following are the food interactions for Prasugrel 5MG Tablet:

• Avoid grapefruit and grapefruit juice as they can increase the concentration of Prasugrel in the blood, leading to an increased risk of bleeding.
• Limit alcohol consumption as it can increase the risk of bleeding and may affect platelet function.
• Prasugrel should be taken with food to enhance its absorption, preferably with a meal or a snack containing some fat.
• Avoid high-fat meals as they may lead to inconsistent absorption of Prasugrel and variable drug levels in the body.
• Do not consume foods or drinks with high levels of vitamin K (like spinach, kale, broccoli, and liver) without medical advice, as they can reduce the effectiveness of Prasugrel.
• Consult your doctor or pharmacist about consuming garlic and ginger, as they may affect blood clotting and interact with Prasugrel's action.
• Avoid cranberry products, including juice, as they may interfere with Prasugrel's metabolism and potentially decrease its effectiveness.
• Inform your healthcare provider about your diet, especially if it includes any herbal supplements, as some herbs may interact with Prasugrel's antiplatelet action.

Prasugrel 5MG Tablets should be stored in a cool, dry area, preferably at room temperature, away from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to external elements. It is crucial not to store the medication in the bathroom or near heat-emitting appliances to avoid compromising its effectiveness. Always check the expiration date before using the tablets, and if they have passed their expiry, it is recommended to consult a pharmacist or healthcare professional for appropriate disposal methods, rather than discarding them in household waste or flushing them down the toilet. Ensure that the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Prasugrel 5MG Tablet:

• Always take the tablet as directed by your doctor; do not adjust the dosage without medical advice.
• It is best taken with a meal or just after a meal to enhance absorption.
• Ensure you complete the full course of medication as prescribed.
• Avoid crushing or chewing the tablet; swallow it whole with a glass of water.
• Inform your doctor if you have any bleeding disorders or upcoming surgeries.
• Regularly monitor your blood pressure and blood sugar levels while on this medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.