Phenergan (25mg) 500 Tablets

Promethazine HCl 25mg tablets primarily exert their effects through multiple mechanisms of action. It acts as a potent antagonist of H1 histamine receptors, effectively blocking the action of histamine, which leads to a reduction in symptoms associated with allergic reactions and inflammation. Additionally, promethazine exhibits anticholinergic properties, inhibiting the activity of acetylcholine at muscarinic receptors, thereby contributing to its sedative and antiemetic effects. By blocking specific serotonin receptors, the drug also possesses antiemetic properties, suppressing nausea and vomiting. Moreover, promethazine's central nervous system (CNS) depressant activity is attributed to its ability to inhibit certain receptors in the brain, resulting in sedation, anxiolytic effects, and potential respiratory depression. This multifaceted mechanism of action makes promethazine a versatile medication for managing various conditions, including allergies, motion sickness, and nausea.

Antihistamine

Tablet

The following are the uses of Promethazine HCl 25mg Tablet:

• Used for controlling severe allergic reactions and relieving symptoms like itching, hives, and difficulty breathing.
• Used for treating nausea and motion sickness, providing effective relief.
• Used for short-term management of insomnia, aiding in sleep induction.
• Used as a pre-operative medication to reduce anxiety and potential adverse reactions.
• Used for treating symptoms of the common cold, such as runny nose and sneezing.
• Used for managing postoperative pain and nausea, ensuring patient comfort.
• Used for suppressing persistent coughs, particularly those caused by respiratory tract infections.

In the case of an overdose of Promethazine HCl 25mg Tablets, individuals may experience severe symptoms such as drowsiness, confusion, and respiratory depression. The severity of the overdose can lead to a decreased level of consciousness and even coma. Prompt medical intervention is necessary, and emergency services should be contacted immediately. Treatment may involve supportive care, including monitoring vital signs and providing respiratory support until the effects of the overdose subside.

In the case of a missed dose of Promethazine HCl 25mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is essential to maintain a consistent dosing routine for optimal therapeutic benefits.

To take Promethazine HCl 25mg Tablets, swallow the tablet whole with a glass of water, following the prescribed dosage instructions provided by your healthcare professional, typically taken one to four times a day or as directed by your doctor.

Promethazine HCl 25mg Tablet should not be used in the following conditions:

• Allergic reactions Patients with a known allergy to Promethazine, other phenothiazines, or any of the tablet's components should avoid this medication.
• Children under 2 years It is contraindicated in very young children due to potential severe side effects.
• Respiratory conditions Should not be used in patients with severe asthma, severe respiratory depression, or severe lung disease, as it can suppress breathing.
• Central Nervous System (CNS) disorders Contraindicated in patients with coma, severe CNS depression, or Reye's syndrome.
• Bone Marrow Depression Not recommended for patients with bone marrow suppression or blood cell disorders.
• Enlarged Prostate Men with enlarged prostate or urinary retention should not take this medication.

The side effects of Promethazine HCl 25mg Tablet may include:

• Drowsiness or sedation
• Blurred vision
• Dry mouth
• Constipation
• Dizziness
• Confusion or disorientation
• Allergic reactions (skin rash, itching)
• Difficulty urinating

Following are the precautions and warnings for Promethazine HCl 25mg Tablet:

• Allergic reactions may occur; discontinue use if signs of hypersensitivity appear and seek medical attention.
• Not recommended for children under 2 years of age due to potential respiratory depression.
• Elderly patients may be more susceptible to side effects, particularly dizziness and confusion.
• May cause drowsiness and impair cognitive function, affecting the ability to drive or operate machinery.
• Avoid alcohol consumption while taking this medication as it can intensify the sedative effects.
• Promethazine can cause extrapyramidal symptoms; use with caution in patients with Parkinson's disease or other similar conditions.
• Patients with epilepsy or seizure disorders should use with caution as it may lower the seizure threshold.

Following are the drug interactions for Promethazine HCl 25mg Tablet:

• Alcohol, opioids, and other central nervous system (CNS) depressants can enhance the sedative effects of promethazine, potentially leading to increased sedation, respiratory depression, and impaired judgment.
• Monoamine oxidase inhibitors (MAOIs) taken within 14 days of promethazine can result in severe and potentially fatal reactions, including hyperpyrexia, muscle rigidity, and seizures.
• Promethazine may reduce the effectiveness of levodopa and other dopaminergic drugs used in Parkinson's disease, possibly requiring dosage adjustments.
• Antihistamines, including promethazine, can inhibit the antiemetic effects of metoclopramide.
• Concomitant use with other anticholinergic drugs may increase the risk of anticholinergic side effects such as dry mouth, blurred vision, and urinary retention.
• Antacids may decrease the absorption of promethazine, reducing its effectiveness.
• Promethazine may decrease the absorption of certain antibiotics, such as tetracyclines, potentially reducing their effectiveness.

Following are the food interactions for Promethazine HCl 25mg Tablet:

• Alcohol consumption should be avoided as it can increase the sedative effects of Promethazine, leading to enhanced drowsiness and dizziness.
• Grapefruit and grapefruit juice are to be avoided as they can increase the concentration of Promethazine in the blood by inhibiting the CYP450 enzyme system, potentially increasing the risk of side effects.
• High-fat meals may delay the absorption of Promethazine, leading to a slower onset of action.
• Caffeine-containing beverages like coffee or tea might reduce the sedative effects of Promethazine, making it less effective for treating sleep-related symptoms.
• Foods rich in tyramine, such as aged cheeses, cured meats, and fermented foods, should be avoided as they can interact with Promethazine and increase blood pressure.
• Chocolate, known to contain both caffeine and tyramine, should be consumed in moderation to prevent potential interactions with Promethazine.
• It's advisable to maintain a balanced diet and stay well-hydrated when taking Promethazine to support overall health and minimize potential side effects.
• Always consult your healthcare provider for specific dietary recommendations and adjustments while using Promethazine.

Promethazine HCl 25mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring they are out of the reach of children and pets. The tablets should be kept in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It is crucial not to store the medication in the bathroom or near sinks to prevent exposure to humidity. Always check the expiration date, and if the tablets are expired or no longer needed, do not flush them down the toilet or throw them into the trash. Instead, contact your local pharmacy or healthcare provider for guidance on safe disposal methods, ensuring that the medication is disposed of in an environmentally friendly manner. Proper storage and disposal practices are essential to maintain the effectiveness of the medication and to prevent any potential harm.

Here are the quick tips for Promethazine HCl 25mg Tablets:

• Take the tablet as directed by your doctor, typically with a full glass of water.
• Swallow the tablet whole, do not crush or chew.
• It can be taken with or without food, but taking it with food may prevent stomach upset.
• Avoid alcohol as it may intensify the medication's side effects.
• Store the tablets at room temperature, away from moisture and light.
• Do not share this medication with others, even with similar symptoms.
• Consult your doctor if symptoms persist or worsen after taking the medication.