Phenylbutazone (100mg/ml) 500ml Suspension

Phenybutazone, the active ingredient in Phrenylbutazone 100mg Syrup/Suspension, primarily exerts its anti-inflammatory and analgesic effects through inhibition of cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. By blocking COX, phenybutazone reduces the production of inflammatory mediators, thereby alleviating pain, inflammation, and fever. This mechanism of action is common among non-steroidal anti-inflammatory drugs (NSAIDs), making phenybutazone effective in managing various inflammatory conditions and providing pain relief.

Nonsteroidal anti-inflammatory drug (NSAID)

Suspension

The following are the uses of Phrenylbutazone 100mg Syrup/Suspension:

• Used for relieving pain and reducing inflammation in horses, especially in musculoskeletal disorders.
• Used for managing pain and inflammation associated with arthritis, joint injuries, and soft tissue injuries in equines.
• Used for treating fever, particularly in cases where reducing inflammation is also beneficial.
• Used for controlling and managing post-operative pain and inflammation following surgical procedures in horses.
• Used for alleviating pain and discomfort in horses with laminitis or navicular disease.
• Used for supporting recovery and reducing inflammation in horses with muscle strains or sprains.
• Used for maintaining comfort and mobility in horses with chronic degenerative joint diseases.

In the case of an overdose of Phrenylbutazone 100mg Syrup/Suspension, symptoms may include gastrointestinal issues, such as nausea, vomiting, and abdominal pain. More severe cases can lead to renal and hepatic dysfunction, and in extreme instances, overdose can result in respiratory depression, seizures, and even coma. It is imperative to seek medical assistance promptly and provide healthcare professionals with the necessary information regarding the amount ingested and the time of overdose.

In the case of a missed dose of Phrenylbutazone 100mg Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your medication regimen. It is recommended to set reminders or use a pill organizer to help you stay on track with your medication.

To administer Phrenylbutazone 100mg Syrup/Suspension, shake the bottle vigorously, measure the prescribed dose with an accurate measuring device like a marked measuring spoon or oral syringe, and take it orally as directed by your healthcare professional, typically once or twice a day, with or without food, following the dosage instructions provided.

Here is a list of conditions and situations when Phenylbutazone 100mg Syrup/Suspension should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Phenylbutazone or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Contraindicated in patients with active gastrointestinal bleeding or a history of gastrointestinal ulcers/bleeding.
• Not recommended for individuals with severe heart failure or heart disease.
• Should be avoided in patients with severe kidney disease or those with a history of kidney problems.
• Contraindicated during the last trimester of pregnancy as it may cause premature closure of the fetal ductus arteriosus.
• Not suitable for children under 12 years of age due to the risk of adverse effects.
• Should not be used in patients with a history of asthma or allergic reactions triggered by aspirin or other NSAIDs.
• Contraindicated in patients with severe dehydration or those who are unable to maintain adequate fluid intake.

The side effects of Phrenylbutazone 100mg Syrup/Suspension may include:

• Stomach pain or gastrointestinal bleeding
• Nausea and vomiting
• Headaches
• Dizziness
• Skin rashes or itching
• Increased sensitivity to sunlight
• Ringing in the ears (tinnitus)
• Changes in blood cell counts

Following are the precautions and warnings for Phrenylbutazone 100mg Syrup/Suspension:

• This medication should not be used in patients with known hypersensitivity or allergy to Phrenylbutazone or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Patients with a history of gastrointestinal bleeding, peptic ulcers, or kidney disease should exercise caution and consult a doctor before use.
• It may increase the risk of cardiovascular events such as heart attack or stroke, especially with long-term use. Regular monitoring is advised.
• Phrenylbutazone can cause liver dysfunction, so periodic liver function tests are recommended during prolonged treatment.
• Elderly patients may be more susceptible to side effects; dosage adjustments might be necessary.
• Avoid alcohol consumption while taking this medication as it may increase the risk of gastrointestinal bleeding.
• Not recommended for use during pregnancy and breastfeeding unless the potential benefits outweigh the risks.

Following are the drug interactions for Phrenylbutazone 100mg Syrup/Suspension:

• Phrenylbutazone may increase the risk of bleeding when taken with anticoagulants like warfarin, requiring close monitoring of blood coagulation.
• It can enhance the effects of other nonsteroidal anti-inflammatory drugs (NSAIDs), leading to increased side effects.
• Potentially serious interactions with corticosteroids, resulting in gastrointestinal bleeding or ulceration.
• May reduce the effectiveness of diuretics and antihypertensive medications, requiring dosage adjustments.
• The risk of renal toxicity is increased when combined with other nephrotoxic drugs.
• Interactions with lithium can lead to increased lithium levels and potential toxicity.
• Caution is advised when using with other medications metabolized by the liver, as Phrenylbutazone may affect their metabolism.

Following are the food interactions for Phrenylbutazone 100mg Syrup/Suspension:

• Avoid consuming grapefruit or grapefruit juice as it can interfere with the metabolism of Phrenylbutazone, leading to increased drug levels in the body and potential toxicity.
• Alcohol consumption should be minimized or avoided as it can increase the risk of gastrointestinal bleeding and liver toxicity when combined with Phrenylbutazone.
• Limit caffeine intake from coffee, tea, or energy drinks as it may enhance the stimulant effects of Phrenylbutazone and cause restlessness and insomnia.
• Avoid high-fat meals as they can potentially slow down the absorption of Phrenylbutazone, affecting its onset of action.
• Consuming fatty fish like salmon or mackerel, which are rich in omega-3 fatty acids, may enhance the anti-inflammatory effects of Phrenylbutazone.
• Dairy products like milk and yogurt can help protect the stomach lining and reduce the risk of gastrointestinal irritation.
• Foods rich in vitamin K, such as leafy greens, can help maintain normal blood clotting function, which may be affected by long-term use of Phrenylbutazone.
• Staying well-hydrated by drinking plenty of water is essential, especially if you experience any signs of dehydration due to the diuretic effects of the medication.

Phrenylbutazone 100mg Syrup/Suspension should be stored with caution, ensuring a cool and dry environment, preferably at room temperature, shielded from direct sunlight and moisture. It is crucial to maintain the medication in its original, tightly sealed container to prevent contamination. Avoid bathroom storage or placing it near heat-emitting appliances like stoves or radiators, as temperature fluctuations can impact the medicine's integrity. Always adhere to the packaging's expiration date, and when disposing of any unused or expired syrup, refrain from flushing it or pouring it down the drain. Consult your pharmacist for appropriate disposal methods, and ensure the medication is kept away from children to prevent accidental consumption.

Following are the quick tips for Phenybutazone 100mg Syrup/Suspension:

• Administer the prescribed dosage as directed by your veterinarian for effective treatment.
• Shake the bottle vigorously before each use to maintain a well-mixed suspension.
• Use an accurate measuring device to ensure the correct dose is given.
• Give the syrup to your pet at regular intervals to maintain a consistent level of medication in their system.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Monitor your pet's response to the medication and report any adverse effects to your veterinarian.
• Ensure the medication is not shared between pets without veterinary guidance.