PILZCIN CREAM

Croconazole cream, a topical antifungal agent, exerts its effect primarily by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. The active ingredient, croconazole, belongs to the imidazole class of antifungals. It disrupts the fungal cell membrane by binding to a specific enzyme called lanosterol 14-alpha-demethylase, which is essential for converting lanosterol to ergosterol. This inhibition leads to the accumulation of toxic sterol intermediates and a deficiency of ergosterol, ultimately compromising the integrity and function of the fungal cell membrane. This mechanism selectively targets fungal cells, as it interferes with a process that is unique to fungal sterol synthesis, while having minimal impact on mammalian cells.

Croconazole

Antifungal (Imidazole)

cream

The following are the uses of Croconazole Cream:

• Used for treating fungal skin infections such as athlete's foot, jock itch, and ringworm.
• Used for relieving itching, redness, and discomfort associated with fungal infections.
• Used for preventing the spread of infection to surrounding skin areas.
• Used for maintaining skin integrity and preventing further damage.
• Used for improving skin appearance and reducing discoloration caused by fungal growth.
• Used for providing targeted treatment directly to the affected skin areas.
• Used for complementing overall fungal infection management, including good hygiene practices.

In the case of an overdose of Croconazole Cream, it is important to recognize that this topical medication is intended for external use only. If ingested, it may cause adverse effects, such as gastrointestinal discomfort or irritation. In such instances, prompt consultation with a healthcare professional is advised. They will provide guidance on the appropriate steps to take, which may include inducing vomiting or administering activated charcoal to minimize absorption.

In the case of a missed dose of Croconazole Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your treatment and maintain the medication's effectiveness. It is crucial to adhere to the prescribed treatment plan for optimal results.

To apply Croconazole Cream, clean and dry the affected area, then apply a thin layer of the cream, gently rubbing it into the skin, usually twice a day or as directed by your healthcare professional.

Here are the conditions or situations when Croconazole Cream should not be used:

• Do not use if you have a known allergy or sensitivity to croconazole or any other azole antifungal medications.
• Avoid using on open wounds, severely inflamed or broken skin.
• Not recommended for individuals with a history of liver problems or liver disease.
• Do not use near the eyes, mouth, or other mucous membranes.
• Contraindicated in patients with a history of hypersensitivity or severe reactions to similar antifungal agents.
• Avoid using on skin areas where there is a possibility of skin-to-skin contact with another person, as the cream may be transferred.
• Do not use if you are pregnant or breastfeeding, unless directed by a healthcare professional.
• Not suitable for children without medical advice.
• Do not use on skin conditions that are not listed on the product's indications.

The side effects of Croconazole Cream may include:

• Skin irritation at the application site
• Burning or stinging sensation
• Redness or inflammation
• Itching or rash
• Dryness or peeling of the skin
• Swelling or blisters
• Allergic reactions (such as hives, difficulty breathing, swelling of the face/lips/tongue)

Following are the precautions and warnings for Croconazole Cream:

• Avoid contact with eyes, nose, and mouth. If accidental contact occurs, rinse thoroughly with water.
• Do not apply to open wounds, cuts, or severely inflamed skin without medical advice.
• Wash your hands before and after applying the cream to avoid contamination.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Do not use this medication for longer than prescribed, and do not use it for conditions other than those for which it was prescribed.
• If you have a known allergy to Croconazole or any other antifungal medications, inform your doctor before using this cream.
• Stop using and seek medical attention if you experience severe irritation, burning, or any signs of an allergic reaction.

Following are the drug interactions for Croconazole Cream:

• Topical corticosteroids, when used concurrently with Croconazole, may lead to increased skin absorption of the corticosteroid, potentially causing systemic effects.
• The use of other topical antifungal agents alongside Croconazole Cream may result in reduced efficacy or increased skin irritation.
• Warfarin and other anticoagulants may experience altered effects, as Croconazole could potentially affect their metabolism.
• Croconazole might interact with oral hypoglycemic agents, requiring closer monitoring of blood glucose levels.
• The application of Croconazole Cream in conjunction with other topical medications, such as benzoyl peroxide or retinoids, may cause skin dryness or irritation.
• There is a potential for increased photosensitivity when using Croconazole Cream in combination with certain photosensitizing drugs.
• Caution is advised when using Croconazole with drugs that prolong the QT interval, as it may increase the risk of cardiac arrhythmias.

Following are the food interactions to consider with Croconazole Cream:

• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of the drug, potentially leading to increased levels of Croconazole in the body.
• Alcoholic beverages might cause skin irritation or dryness when used with Croconazole Cream, so it's best to limit alcohol consumption.
• Dairy products, especially those high in fat, may interact with the absorption of Croconazole, so it's advisable to use the cream at a different time than consuming dairy.
• Spicy foods can sometimes exacerbate skin conditions, and when using Croconazole Cream, it might be wise to moderate the intake of very spicy dishes.
• Foods rich in vitamin E, like nuts and seeds, could potentially affect the skin's response to the medication, so consider moderation in their consumption.
• Avoid applying the cream immediately after eating acidic foods like citrus fruits, as they may cause skin sensitivity.
• Certain herbal teas, such as those containing St. John's Wort, could potentially interact with Croconazole; consult a healthcare provider if you regularly consume herbal remedies.
• Always consult with your healthcare provider or pharmacist if you have specific dietary concerns or potential interactions with other medications you are taking.

Croconazole Cream should be stored in a cool and dry place, preferably at room temperature, ensuring it remains protected from direct sunlight, heat, and moisture. Keep the cream in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. It is crucial not to store it in bathrooms or near heat-emitting appliances to preserve its effectiveness. Always adhere to the expiry date indicated on the packaging, and when the time comes to discard the cream, do not flush it down the toilet or pour it into drainage systems. Instead, consult your pharmacist or local waste management guidelines for safe disposal practices. Additionally, exercise caution to keep the cream out of children's reach to prevent accidental exposure.

Following are the quick tips for Croconazole Cream:

• Wash and dry the affected area before applying the cream.
• Apply a thin layer of cream to the affected skin and nearby skin as directed.
• Gently rub the cream into the skin until it is absorbed.
• Wash your hands after applying the cream, unless you are treating the hands.
• Avoid contact with eyes and mucous membranes.
• Do not cover the treated area with bandages or airtight dressings.
• Continue using the cream for the full prescribed length of treatment, even if symptoms improve.