Piozer (45mg) 14 Tablets

Pioglitazone is an oral medication used to treat type 2 diabetes in adults and children aged 10 and older. It belongs to a class of drugs called thiazolidinediones that work by increasing the body's sensitivity to insulin. Insulin is a natural hormone that helps control blood sugar levels and when pioglitazone is taken, it works by binding to specific receptors called peroxisome proliferator-activated receptor gamma (PPAR-γ), this action enhances the molecular pathways involved in insulin sensitivity, specifically in muscle and fat cells. This increased sensitivity helps the cells respond better to insulin, leading to improved glucose uptake and metabolism, and ultimately helping to lower blood sugar levels.

Thiazolidinedione Antidiabetic Medication

Unveiling its multifaceted uses and transformative applications as follows:

• Treatment of diabetes mellitus type 2
• Lowering serum glucose levels in patients with diabetes mellitus
• Reducing the risk of development of diabetic complications
• Treatment of hyperglycaemia in patients with diabetes mellitus type 2 despite optimised oral therapy
• Lowering PPG levels in patients with known NPCDHF
• Reducing the progression of diabetic nephropathy
• Improving the lipid profile
• Reducing the risk of developing atherosclerotic events
• Providing better glycaemic control in comparison to sulfonylureas
• Moisturising dry skin in patients with diabetic mellitus type 1 or type 2
• Reducing the incidence of UTI and GD

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• The typical starting dose of Pioglitazone for the treatment of diabetes mellitus is 15mg once daily.
• The maximum dose of Pioglitazone is 45mg once daily.
• Doses of Pioglitazone should be adjusted on an individual basis and should be based on glycemic control and individual patient tolerance.
• Pioglitazone should be used with caution in patients with fluid retention or heart failure, starting at 15 mg once daily and increasing the dose only after adequate clinical response and tolerance of this dose has been demonstrated.

An overdose of Pioglitazone can be treated with gastric lavage (stomach pumping) if the overdose occurs within 1-2 hours of ingestion. Historically, activated charcoal was given alongside gastric lavage, but there is limited evidence to support its use in clinical emergencies. There is no specific antidote to Pioglitazone overdose, and treatment is generally supportive, aimed at mitigating the adverse effects and managing any comorbidities or medical conditions that may arise. Close observation of the patient is necessary, with consideration given to cardiovascular monitoring if there is a concern for congestive heart failure or acute myocardial injury. Hypoglycemia may occur in acute overdose situations and requires prompt treatment with intravenous glucose or oral glucose replacements. In cases of severe or refractory hypoglycemia, the patient may require glucagon injections or admission to an intensive care unit for more aggressively managed glucose supplementation. The patient will typically be observed for a minimum of 6-8 hours, and preferably overnight, to ensure clinical stability before discharge. It is important to seek immediate medical attention if you have overdosed on Pioglitazone, as the necessary treatment is largely supportive and the decisions on how to treat are made based on each patient's particular presentation.

Maintaining a regular schedule for your medications, such as Pioglitazone, is important. If you miss a dose, it is recommended to take it as soon as possible, unless it is almost time for the next scheduled dose. In this case, it is best to skip the missed dose and resume the regular schedule. It is unnecessary to double up on the medication to make up for the missed dose, as this may increase the risk of side effects. If you have any questions or concerns about missing a dose, it is best to consult your physician or pharmacist for guidance regarding your specific situation. They can provide you with the most accurate and up-to-date information.

Before starting Pioglitazone 45mg, it is crucial to read the medication guide provided by your pharmacist. If you have any queries, do not hesitate to ask your doctor or pharmacist. This medication is usually taken by mouth, once daily, with or without food. The dosage is tailored to your medical condition and response to treatment. To minimize side effects, your doctor may gradually increase the dose. It is important to drink plenty of fluids while taking this medication to prevent dehydration. For the best results, regular usage of this medication is recommended. To avoid forgetting, take it at the same time each day. If your medical condition does not improve or worsens, let your doctor know. It is common to experience increased blood sugar levels at the start of treatment with pioglitazone. If this effect persists or worsens, consult your doctor. It is essential to inform your doctor about all other medications you are using, including vitamins and herbs, as pioglitazone may interact with certain drugs, such as insulin or metformin. Suddenly stopping this drug may result in withdrawal symptoms such as nausea, vomiting, itching, numbness, sweating, dizziness, pale skin, confusion, seizures, and rapid weight loss. If you need to stop taking this medication, ensure to gradually reduce the dose under your doctor's guidance. Adhering to these guidelines will ensure you use Pioglitazone 45mg safely. If you have any questions or experience any issues while taking this medication, consult a healthcare professional for guidance.

Discerning instances where this medication may not be appropriate:

• You are allergic to Pioglitazone or any of the other ingredients in these medications.
• You have active diabetic ketoacidosis (a dangerous buildup of acids in the blood due to diabetes).
• You have moderate to severe liver disease or impairment.
• You have a history of heart failure or fluid build-up in your body.
• You have serious kidney problems or are undergoing dialysis.
• You are pregnant or planning to become pregnant.
• You are breastfeeding.

Unraveling the side effects lurking behind this medications are as follows:

• Edema

• Bone fractures

• Weight gain

• Gout

• Inflammatory bowel disease

• Respiratory infection

• Leukemia

Store Pioglitazone in a cool, dry place preferably at room temperature, which is between 68°F to 77°F (20°C to 25°C). Avoid placing it in direct sunlight or near sources of heat or moisture, as this can hamper the medication's effectiveness. Keep Pioglitazone out of reach for children, as it is intended for adult use only and may be harmful to children or pets. Freezing Pioglitazone is not recommended as extreme cold temperatures can alter the composition of the medication, rendering it ineffective. It is also important to track the expiration date of your Pioglitazone medication, as it does have an expiration date and should be replaced after two to three years of use. You can find the expiration date listed on the label or packaging. If you have any questions or concerns about storing your medication, reach out to your pharmacist for guidance. Following these storage instructions ensures that your Pioglitazone medication remains effective and safe for use. Please let me know if you'd like me to clarify or expand on any of the provided storage tips.