PIRIUM IMP 4MG TAB (PIMOZIDE)

Pimozide's primary mechanism of action is its strong antagonistic effect on dopamine receptors, particularly the D2 receptors. By blocking these receptors, it reduces dopamine-mediated neurotransmission in various regions of the brain. This action is especially relevant in the mesolimbic pathway, where it helps regulate dopamine activity, thereby reducing psychotic symptoms. The therapeutic effects of pimozide are attributed to its ability to alleviate dopamine-related imbalances in the brain, making it effective in managing conditions like schizophrenia and Tourette syndrome.

Antipsychotic

Tablet

The following are the uses of PIMOZIDE 4MG Tablet:

• Used for managing symptoms of schizophrenia, reducing hallucinations and delusions.
• Used for treating Tourette's syndrome to control involuntary movements and vocal tics.
• Used for alleviating anxiety and agitation in patients with severe behavioral problems.
• Used for supporting individuals with persistent, distressing thoughts and compulsive behaviors.
• Used for stabilizing mood and reducing psychotic episodes.
• Used for enhancing treatment of resistant depression when combined with antidepressants.
• Used for improving overall functioning and quality of life in mental health disorders.

In the case of an overdose of PIMOZIDE 4MG Tablets, it is important to seek medical assistance promptly. Symptoms may include severe drowsiness, restlessness, tremors, muscle stiffness, and in extreme cases, difficulty breathing or unconsciousness. Do not induce vomiting, but rather seek professional help as they can provide appropriate treatment and support to manage the overdose effectively, ensuring the patient's safety and well-being.

In the case of a missed dose of PIMOZIDE 4MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. It is crucial to maintain consistency with this medication for optimal therapeutic effects.

To take PIMOZIDE 4MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your doctor, typically starting with a low dose and gradually increasing as directed.

Following are the conditions/situations when PIMOZIDE 4MG Tablet should not be used:

• Should not be taken by individuals with a known allergy to PIMOZIDE or similar medications.
• Contraindicated in patients with severe liver or kidney disease.
• Not suitable for patients with a history of Parkinson's disease or other similar conditions.
• Should not be used in individuals with certain heart conditions, such as QT prolongation or heart rhythm disorders.
• Contraindicated during pregnancy or breastfeeding.
• Not recommended for children and elderly patients without proper medical evaluation.
• Avoid if you have a history of seizures or epilepsy.
• Do not use if you have a blood disorder or bone marrow depression.
• PIMOZIDE should not be combined with certain medications, such as antidepressants, antipsychotics, or other drugs affecting the central nervous system.

The side effects of PIMOZIDE 4MG Tablet may include:

• Dry mouth
• Dizziness
• Headache
• Constipation
• Nausea and vomiting
• Weight gain
• Fatigue or drowsiness
• Muscle stiffness or tremors

Following are the precautions and warnings for PIMOZIDE 4MG Tablet:

• Do not use if you have a known allergy to Pimozide or any other similar medications.
• This medication may cause QT prolongation, a heart rhythm condition, hence patients with existing heart problems should use with caution and under medical supervision.
• Pimozide can cause drowsiness and dizziness, so avoid driving or operating heavy machinery until you know how the medication affects you.
• Alcohol consumption should be avoided as it may increase the risk of certain side effects.
• Elderly patients may be more sensitive to the side effects, so dosage adjustments might be necessary.
• Pimozide should be used with caution in patients with liver disease, as it is metabolized by the liver.
• Do not abruptly stop taking this medication without consulting your doctor, as it may lead to withdrawal symptoms.

Following are the drug interactions for PIMOZIDE 4MG Tablet:

• Strongly inhibits CYP3A4, leading to increased levels of drugs metabolized by this enzyme, such as cisapride, pimozide, and ergot alkaloids, which can result in adverse effects.
• Co-administration with other antipsychotic medications may increase the risk of extrapyramidal symptoms and other adverse effects.
• Drugs that prolong the QT interval (e.g., certain antiarrhythmics, antibiotics, and antipsychotics) can enhance the QT-prolonging effect of pimozide, increasing the risk of cardiac arrhythmias.
• Antidepressants, including SSRIs and tricyclic antidepressants, may have additive effects on serotonin levels and increase the risk of serotonin syndrome.
• Pimozide may enhance the effects of sedatives and hypnotics, potentially leading to excessive sedation.
• Grapefruit juice should be avoided as it can inhibit CYP3A4 metabolism, leading to increased pimozide levels and toxicity.
• Antifungal agents like ketoconazole can significantly increase pimozide concentrations by inhibiting CYP3A4 metabolism.

Following are the food interactions for PIMOZIDE 4MG Tablet:

• Avoid grapefruit and grapefruit juice as they can interfere with the drug's metabolism and potentially increase the levels of PIMOZIDE in the body, leading to an increased risk of side effects.
• Alcohol consumption should be minimized or avoided as it can enhance the sedative effects of PIMOZIDE, causing excessive drowsiness and impaired coordination.
• High-fat meals may slightly delay the absorption of PIMOZIDE, but this is not expected to significantly impact its effectiveness.
• Caffeine intake should be moderate as it can potentially interact with PIMOZIDE, leading to increased anxiety or restlessness.
• Avoid eating large amounts of chocolate, especially dark chocolate, as it contains a compound that can inhibit the breakdown of PIMOZIDE, possibly leading to higher drug levels in the body.
• Be cautious with foods rich in vitamin C, as high doses of vitamin C may affect the metabolism of PIMOZIDE, although normal dietary intake is unlikely to cause issues.
• Salt and potassium levels in the diet should be monitored, especially in individuals with existing electrolyte imbalances, as PIMOZIDE can affect these levels.
• Always consult your healthcare provider for personalized advice regarding any specific dietary restrictions or recommendations while taking PIMOZIDE.

Pimozide 4MG tablets should be stored in a cool, dry area at room temperature, protected from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. It is crucial not to store them in bathrooms or near heat-emitting appliances to avoid degradation. Regularly check the expiration date, and if the medication is no longer required or has expired, it should be disposed of carefully, not flushed or poured down the drain. Consult your pharmacist for guidance on appropriate disposal methods to ensure safety and environmental responsibility, and always keep medicines out of children's reach.

Following are the quick tips for PIMOZIDE 4MG Tablet:

• Consult a doctor for the right dosage and duration; individual needs may vary.
• Swallow the tablet whole without crushing or chewing for optimal absorption.
• Take the tablet with a full glass of water to aid swallowing.
• Maintain a consistent daily routine for taking the medication.
• Avoid missing doses; if you miss one, consult your doctor for instructions.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Keep the medication out of children's reach to prevent accidental consumption.