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Product Information
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Description
Amantadine sulfate exerts its effects through two main mechanisms. First, as an antiviral agent, it inhibits the M2 protein of the influenza A virus, blocking the ion channel essential for viral replication. This action prevents the acidification required for the viral core to release its RNA into the host cell. Second, in the context of Parkinson's disease, amantadine enhances the release of dopamine and inhibits its reuptake, which helps improve motor function and alleviate symptoms. Overall, amantadine is effective in treating both viral infections and movement disorders by modulating viral activity and dopamine levels.
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Ingredients
Amantadine sulphate -
Drug Class
Antiviral
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Dosage Form
Tablet
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Uses
This medicine is used to treat:
Indigestion
- Influenza A prevention and treatment
- Parkinson's disease management
- Reduces drug-induced dyskinesia
- Pain relief for post-herpetic neuralgia
- Potential cognitive enhancement
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Dosage
Amantadine Sulfate dosage recommendations are:
- Influenza A and Parkinson's disease -Elderly Patients - Initial Treatment - 100 mg once daily, increase to 200 mg daily (100 mg twice daily) after at least one week. 100 mg once daily, adjusted based on sensitivity and kidney function, with a lower maintenance dose if renal function is impaired, children - Not suitable for use.
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In case of Overdose
If you accidentally take too many capsules, or someone else takes any of your medicine, you should tell your doctor at once or contact the nearest accident and emergency department. Show any left-over medicines or the empty packet to the doctor.
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Missed Dose
Do not worry. If you miss a dose, take another as soon as you remember, unless it is almost time for your next dose. Then go on as before. Do not take a double dose to make up for a forgotten dose.
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How To Use
Swallow the capsules whole with a drink of water.
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When Not to Use
Do not take Amantadine sulfate capsules:
- If you are allergic to amantadine sulfate.
- If you have a history of fits (convulsions), such as epilepsy.
- If you have ever had an ulcer in your stomach or small intestine.
- If you have serious kidney disease.
- If you are pregnant, planning to become pregnant, or breastfeeding.
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Side Effects
Unraveling the side effects lurking behind this drug product are the following:
- Nausea
- Dizziness
- Insomnia
- Dry mouth
- Confusion
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Precautions & Warnings
Here are some important warnings and precautions patients should keep in mind when using Amantadine sulfate:
- Avoid use in patients with a history of seizures
- Use with caution in individuals with renal impairment
- Monitor for signs of hallucinations or confusion
- Assess for potential drug interactions, especially with CNS stimulants
- Not recommended during pregnancy unless necessary
- Caution in elderly patients due to increased risk of side effects
- Discontinue if severe side effects occur, such as rash or difficulty breathing
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Drug Interactions
Drug interactions with amantadine sulfate include:
- Anticholinergics (additive anticholinergic effects)
- Methocarbamol (increased risk of CNS depression)
- Levodopa (may reduce the effectiveness of amantadine)
- Quetiapine (increased risk of sedation)
- Haloperidol (increased risk of CNS effects)
- Cimetidine (increases amantadine levels)
- Ranitidine (increases amantadine levels)
- Diuretics (may alter amantadine excretion)
- Other CNS stimulants (additive CNS effects)
- Antihypertensives (may have additive hypotensive effects)
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Food Interaction
The food interactions that should be considered while using Amantadine Sulfate are:
- Alcohol can increase the risk of side effects like dizziness and drowsiness, which are also potential side effects of amantadine.
- In moderate amounts, caffeine doesn’t typically interact with amantadine, but excessive caffeine can increase side effects such as jitteriness or insomnia.
- There is no strong evidence suggesting that high-protein foods affect amantadine directly, but maintaining a balanced diet is beneficial for overall health.
- Grapefruit and grapefruit juice can interact with various medications, though amantadine is not commonly listed among them. Discuss your diet and any supplements with your healthcare provider to avoid unexpected interactions.
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Storage/Disposal
Amantadine sulfate should be stored properly to maintain its effectiveness. Store the product at a temperature between 15°C and 30°C in a cool, dry place, away from direct heat, light, and moisture. Ensure the container is tightly closed to prevent contamination. For safety purposes, keep Amantadine sulfate out of reach of children and pets to avoid accidental ingestion. It is advisable to avoid storing the product in humid or warm areas, such as bathrooms or kitchens. If you have any questions or concerns about proper storage, consult your doctor or pharmacist for further guidance to ensure the product’s quality and safety.
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