PLADEXSAL 500ML

Glucose infusion, when administered intravenously, acts by directly replenishing glucose levels in the bloodstream. The mechanism of action is straightforward; glucose molecules from the infusion solution are rapidly absorbed into the systemic circulation, elevating blood glucose concentrations. This infusion provides a readily available source of energy, especially for tissues that primarily rely on glucose metabolism, such as the brain and red blood cells. By increasing the availability of glucose, the infusion supports cellular metabolism, enhances tissue function, and helps maintain normal physiological processes, particularly in situations where oral glucose intake is insufficient or compromised.

Glucose

Intravenous fluid.

Infusion

The following are the uses of Glucose Infusion:

• Used for providing immediate energy to cells, especially in critically ill patients.
• Used for treating severe hypoglycemia (low blood sugar) to rapidly raise glucose levels.
• Used for managing blood sugar levels in diabetic patients during surgery or medical emergencies.
• Used for improving recovery and reducing complications post-surgery.
• Used for preventing organ damage in patients with severe infections or trauma.
• Used for stabilizing patients with severe metabolic disorders.
• Used for maintaining fluid and electrolyte balance in critical care settings.
• Used for supporting the nutritional needs of patients unable to eat or absorb nutrients orally.

In the case of an overdose of Glucose Infusion, the primary concern is the rapid rise in blood glucose levels. Symptoms may include excessive thirst, frequent urination, and hyperglycemia. Overdose can lead to severe dehydration and electrolyte imbalances. Prompt medical intervention is necessary to manage these complications, which may involve intravenous fluid administration and close monitoring of vital signs and blood sugar levels. Timely treatment can effectively mitigate the risks associated with glucose infusion overdose.

In the case of a missed dose of Glucose Infusion, it is important to act promptly. If you realize you have missed an infusion, contact your healthcare professional for guidance on how to proceed. They may advise you to administer the missed dose as soon as possible or provide instructions on adjusting the timing of the next dose. Never try to compensate for a missed dose by doubling the next one without medical advice, as this could lead to potential health risks.

To administer the Glucose Infusion, prepare the solution as directed, ensuring it is properly mixed, and then connect the infusion set to the solution bag. Insert the catheter into a suitable vein and regulate the flow rate using the infusion pump or roller clamp to deliver the prescribed glucose concentration at the recommended rate.

Following are the conditions/situations when Glucose Infusion is not recommended:

• Not suitable for patients with hyperglycemia (high blood sugar) or diabetes, especially if not well-controlled.
• Contraindicated in individuals with glucose-galactose malabsorption syndrome.
• Should not be used in patients with severe renal (kidney) impairment or end-stage renal disease.
• Not recommended for patients with severe liver disease or impaired liver function.
• Avoid in patients with severe pulmonary edema or congestive heart failure.
• Not suitable for individuals with severe thrombosis or hypercoagulability.
• Contraindicated in patients with known hypersensitivity or allergic reactions to glucose solutions.
• Should not be used to treat dehydration in patients with hypernatremia (high blood sodium levels).

The side effects of Glucose Infusion may include:

• Hypersensitivity reactions such as itching, rash, or hives
• Localized swelling, redness, and pain at the infusion site
• Hyperglycemia (high blood sugar) leading to increased thirst, frequent urination, and fatigue
• Hypokalemia (low potassium levels) causing muscle weakness and irregular heartbeat
• Fluid overload, especially in patients with heart or kidney conditions
• Thrombophlebitis (vein inflammation) or infection at the infusion site
• Nausea and vomiting
• Electrolyte imbalances, particularly in prolonged or high-dose infusions

Following are the precautions and warnings for Glucose Infusion:

• Not recommended for patients with known allergies to glucose or any excipients in the infusion.
• Caution in patients with diabetes mellitus, as glucose infusion can significantly impact blood sugar levels.
• Careful monitoring of blood glucose levels is essential during and after the infusion.
• Should be administered with caution in patients with kidney or liver dysfunction.
• Patients with fluid overload conditions should be closely monitored for signs of volume overload.
• May cause thrombophlebitis if infused peripherally; central venous access is preferred.
• Discontinue immediately if signs of hypersensitivity or severe adverse reactions occur.
• Always use under proper medical supervision and monitor patient's response.

Following are the drug interactions for Glucose Infusion:

• Glucose Infusion may interact with insulin or oral hypoglycemic drugs, requiring careful blood glucose monitoring to adjust diabetes medications accordingly.
• The effect of anticoagulants like heparin can be reduced due to the hyperosmolarity caused by glucose.
• Diuretics, especially thiazide diuretics, may decrease the efficacy of Glucose Infusion by increasing urinary glucose loss.
• Beta-blockers can mask the early warning symptoms of hypoglycemia, making glucose monitoring essential.
• Concomitant use with vasopressor agents like norepinephrine may require dosage adjustments due to changes in blood pressure and fluid balance.
• Corticosteroids can increase blood glucose levels, necessitating close monitoring during Glucose Infusion.
• Combining with certain chemotherapeutic agents may affect glucose metabolism and require adjustments in infusion rates.

Following are the food interactions for Glucose Infusion:

• Avoid excessive consumption of sugary foods and beverages during and after the infusion, as it can lead to rapid spikes in blood glucose levels.
• Maintain a balanced diet with complex carbohydrates, proteins, and healthy fats to ensure stable blood sugar levels.
• Avoid high-fat meals as they may affect the absorption and distribution of glucose.
• Limit caffeine intake as it can influence blood glucose levels and potentially interact with the effects of the infusion.
• Stay hydrated with water to ensure proper glucose distribution and avoid dehydration.
• Consider a diet rich in fiber to support stable glucose metabolism and overall digestive health.
• Avoid extreme dieting or fasting during and after the infusion period to prevent hypoglycemic episodes.
• Always consult healthcare professionals for personalized dietary recommendations based on your medical condition and response to the glucose infusion.

Glucose Infusion storage and disposal should be done with proper attention to ensure its effectiveness and safety. Store the infusion in a clean, dry area at room temperature, away from direct sunlight and heat sources. Keep the infusion in its original packaging, tightly sealed to maintain sterility. Avoid freezing or exposing it to extreme temperatures, as this can alter its composition. Always check the expiry date, and do not use the infusion if it has expired. Dispose of any unused or leftover glucose infusion according to local guidelines; do not pour it down the drain or flush it, as it can cause environmental harm. Consult healthcare professionals for guidance on proper disposal methods, and keep it away from children to prevent accidental access.

Following are the quick tips for Glucose Infusion:

• Administer the infusion under medical supervision to ensure proper monitoring.
• Ensure the infusion is administered through a dedicated intravenous line to avoid contamination.
• Regularly check the infusion site for signs of infection or irritation.
• Monitor blood glucose levels during the infusion to prevent hypoglycemia or hyperglycemia.
• Adjust the infusion rate as directed by healthcare professionals to achieve desired glucose levels.
• Report any adverse reactions or changes in patient's condition immediately.
• Store the glucose solution as per manufacturer's instructions, away from direct sunlight.
• Ensure proper disposal of used infusion sets and materials to maintain hygiene.