Pletaal (50mg) 30 Tablets

Cilostazol's primary mechanism of action involves inhibiting phosphodiesterase type 3 (PDE3), an enzyme found in the blood vessels and platelets. By blocking PDE3, cilostazol increases the intracellular levels of cyclic adenosine monophosphate (cAMP), which in turn leads to several effects. It inhibits platelet aggregation by suppressing the activation of platelets, reducing the risk of blood clot formation. Additionally, cilostazol promotes vasodilation by relaxing the smooth muscles in the arterial walls, improving blood flow and circulation, particularly in the legs. This dual action contributes to its therapeutic benefits in managing intermittent claudication and other vascular disorders.

Cilostazol 50mg

Phosphodiesterase-3 inhibitor.

Tablet

The following are the uses of Cilostazol 50mg Tablet:

• Used for managing intermittent claudication, improving walking distance and reducing pain in the legs.
• Used for treating peripheral vascular disease, enhancing blood flow to the legs.
• Used to prevent stroke and mini-stroke (TIA) recurrence by thinning the blood and preventing clot formation.
• Used for treating symptoms of poor circulation, such as leg pain and cramping.
• Used to reduce the risk of blood clots forming in the legs, especially after surgery.
• Used for managing vascular disorders, improving blood vessel health.
• Used to alleviate symptoms of Raynaud's phenomenon, reducing the frequency and severity of attacks.
• Used to promote overall cardiovascular health and circulation in individuals with vascular conditions.

In the case of an overdose of Cilostazol 50mg Tablets, individuals may experience severe side effects, including increased heart rate, dizziness, and difficulty breathing. The severity of symptoms can vary based on the amount ingested. Promptly seek medical advice if an overdose is suspected, as early intervention is vital. Emergency medical care may involve gastric lavage, monitoring vital signs, and supportive care to manage symptoms and prevent potential complications. Quick action can help mitigate the risks associated with overdosing on this medication.

In the case of a missed dose of Cilostazol 50mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare professional for advice on how to safely resume your medication and adjust your dosing schedule.

To take Cilostazol 50mg Tablet, swallow the tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, usually twice a day with a 12-hour interval between doses.

Following are the conditions/situations when Cilostazol 50mg Tablet should not be used:

• Do not take if you have a known allergy to Cilostazol or any other ingredients in the tablet.
• Contraindicated in individuals with severe heart failure.
• Should not be used if you have a history of bleeding disorders or if you are at high risk of bleeding.
• Not recommended for individuals with uncontrolled high blood pressure.
• Avoid using this medication if you have recently had a heart attack.
• Do not take this medication if you have severe liver disease or impaired liver function.
• Contraindicated in patients with severe kidney disease or end-stage renal disease.
• Not suitable for individuals with a history of seizures or epilepsy.

The side effects of Cilostazol 50mg Tablet may include:

• Headache
• Dizziness
• Diarrhea
• Nausea
• Muscle pain
• Increased heart rate
• Skin rash or itching
• Easy bruising or bleeding

Following are the precautions and warnings for Cilostazol 50mg Tablet:

• Do not take this medication if you are allergic to Cilostazol or any of its ingredients.
• Patients with a history of heart disease, hypertension, or liver disease should use this medication with caution, as it may worsen these conditions.
• Cilostazol may increase the risk of bleeding, so individuals with bleeding disorders or those taking anticoagulant medications should be closely monitored.
• Avoid consuming grapefruit or grapefruit juice while on this medication, as it can affect the drug's effectiveness.
• This medication may cause dizziness or lightheadedness; avoid driving or operating heavy machinery until you know how it affects you.
• Elderly patients may be more sensitive to the side effects, so dosage adjustments might be necessary.
• Cilostazol should be used with caution in patients with diabetes, as it may affect blood glucose levels.
• Inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Cilostazol 50mg Tablet:

• Concomitant use with strong CYP3A4 inhibitors like ketoconazole, clarithromycin, or ritonavir can increase Cilostazol levels, potentially leading to increased side effects.
• Cilostazol may increase the concentration of digoxin, requiring careful monitoring of digoxin levels.
• The use of Cilostazol with other antiplatelet agents like aspirin or warfarin can enhance the risk of bleeding.
• Cilostazol may interact with certain calcium channel blockers like verapamil, leading to increased Cilostazol levels.
• Combining Cilostazol with other vasodilators may result in additive hypotensive effects.
• The risk of bleeding may be increased when Cilostazol is taken with nonsteroidal anti-inflammatory drugs (NSAIDs).
• Cilostazol may affect the metabolism of drugs metabolized by CYP2C19, potentially altering their effectiveness.

Following are the food interactions to be aware of when taking Cilostazol 50mg Tablets:

• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Cilostazol, potentially leading to increased drug levels in the blood and heightened risk of side effects.
• Consuming alcohol while on Cilostazol is not recommended. Alcohol may increase the risk of bleeding and may also affect the effectiveness of the medication.
• Cilostazol may be taken with or without food, but a consistent routine is advised to ensure optimal absorption.
• Avoid high-fat meals as they may affect the absorption of Cilostazol, potentially reducing its effectiveness.
• Limit caffeine intake as it may increase the heart rate and blood pressure, which could counteract the effects of Cilostazol.
• Avoid eating brie cheese, fermented foods, and aged cheese as they may interact with Cilostazol and increase the risk of bleeding.
• Maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall health and cardiovascular function while taking Cilostazol.
• Always follow the dosage instructions provided by your healthcare professional for the best results and minimal food-related interactions.

Cilostazol 50mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, or moisture. The original container should be used to keep the tablets protected and ensure their effectiveness. It is crucial not to store them in the bathroom or near the kitchen sink, as humidity and temperature fluctuations can impact the medication's quality. Always check the expiration date before using the tablets, and dispose of any unused or expired medication responsibly. Avoid flushing the tablets down the toilet or sink; instead, consult your pharmacist or local waste management guidelines for safe disposal practices. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Cilostazol 50mg Tablet:

• Take the tablet as directed by your doctor, typically twice a day.
• Consume the tablet whole with a full glass of water, preferably with food.
• Maintain a consistent dosing schedule, ideally at evenly spaced intervals.
• Avoid crushing, chewing, or breaking the tablet to ensure proper absorption.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Do not double the dose to make up for a missed one; continue with the next scheduled dose.
• Store the medication at room temperature, away from moisture and light.