Polygynax (Vaginal) 6 Capsules (Pack)

The combination of Neomycin, Nystatin, and Polymyxin B Sulfate in this capsule exhibits a synergistic antimicrobial effect. Neomycin, an aminoglycoside, binds to bacterial ribosomes, disrupting protein synthesis in susceptible bacteria. Nystatin, an antifungal agent, binds to ergosterol in the fungal cell membrane, creating pores and causing the leakage of intracellular components. Polymyxin B, a cyclic polypeptide, disrupts the integrity of the bacterial cell membrane by interacting with its phospholipids, leading to cell death. Together, these mechanisms effectively target a broad spectrum of bacteria and fungi, making this capsule a potent antimicrobial agent.

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Neomycin, nystatin, polymyxin B sulphate

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Antibiotic/Antifungal/Polymyxin combination.

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Capsule

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The following are the uses of Neomycin, nystatin, polymyxin B sulphate Capsule:

• Used for treating bacterial infections in the intestines, such as Escherichia coli
• Used for preventing bacterial infections post-surgery
• Used for managing hepatic coma
• Used for reducing the risk of infections in patients with low white blood cell counts
• Used for treating skin infections caused by bacteria
• Used for eye infections like conjunctivitis
• Used for preventing and treating infections in burn patients
• Used for suppressing intestinal bacteria to support the absorption of certain medications

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In the case of an overdose of Neomycin, nystatin, polymyxin B sulphate Capsule, symptoms may include nausea, vomiting, diarrhea, and potential hearing loss or kidney damage. If you suspect an overdose, seek medical attention immediately. Prompt treatment can help manage the symptoms and reduce the risk of long-term complications. It is crucial to act quickly and not delay seeking medical advice.

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In the case of a missed dose of Neomycin, nystatin, and polymyxin B sulphate Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for advice on how to safely resume your medication.

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To take the Neomycin, nystatin, polymyxin B sulphate Capsule, swallow the capsule whole with a full glass of water, ensuring you follow the prescribed dosage instructions provided by your healthcare professional, typically taken orally twice a day, or as directed by your doctor.

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Following are the conditions when Neomycin, nystatin, polymyxin B sulphate Capsule should not be used:

• Avoid using if you have a known allergy or sensitivity to any of the components, including Neomycin, Nystatin, or Polymyxin B.
• Do not take this medication if you have a hearing loss or a condition called myasthenia gravis.
• Contraindicated in individuals with kidney disease or a history of kidney problems.
• Should not be used in patients with a history of neuromuscular disorders.
• Not suitable for infants, especially premature babies, due to the risk of nerve damage.
• Avoid using if you have a perforated bowel or intestinal conditions like ulcerative colitis or Crohn's disease.

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The side effects of Neomycin, Nystatin, and Polymyxin B Sulfate Capsule may include:

• Ear pain or discomfort
• Itching or rash at the application site
• Hearing loss or ringing in the ears (tinnitus)
• Dizziness or vertigo
• Nausea and vomiting
• Skin redness or irritation
• Allergic reactions (such as hives, itching, or difficulty breathing)
• Kidney damage (when used for prolonged periods or in high doses)

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Following are the precautions and warnings for Neomycin, Nystatin, and Polymyxin B Sulfate Capsules:

• This medication is not recommended for individuals with known allergies to any of its components, including Neomycin, Nystatin, and Polymyxin B.
• Caution should be exercised in patients with kidney impairment as these antibiotics are primarily excreted through the kidneys.
• Prolonged use of this medication may lead to the overgrowth of nonsusceptible organisms, including fungi.
• Patients with hearing impairment or pre-existing kidney issues should be closely monitored during treatment.
• Avoid using other otic medications or cleaning the ear canal without consulting a healthcare professional.
• Do not use this medication if the ear drum is perforated or if there is any discharge from the ear.
• Discontinue use and seek medical attention if symptoms persist or worsen after 7 days of treatment.
• Keep out of reach of children and use only as directed by a healthcare provider.

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Following are the drug interactions for Neomycin, Nystatin, and Polymyxin B Sulfate Capsule:

• Aminoglycosides (e.g., kanamycin, tobramycin) and other nephrotoxic drugs may increase the risk of kidney damage when used with neomycin.
• Neomycin can bind to certain drugs like sulfasalazine, reducing their absorption and effectiveness.
• Anticoagulants like warfarin may have their effects enhanced, leading to bleeding risks.
• When combined with other ototoxic medications (e.g., cisplatin, furosemide), the risk of hearing impairment may increase.
• Polymyxin B can interact with neuromuscular blocking agents, enhancing their effects and potentially prolonging paralysis.
• Live bacterial vaccines may have reduced effectiveness when administered with polymyxin B.
• Nystatin absorption is minimal, but it may decrease the absorption of other concurrently administered oral medications.

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Following are the food interactions for Neomycin, Nystatin, and Polymyxin B Sulfate Capsule:

• Avoid consuming dairy products like milk, cheese, and yogurt within 2 hours of taking this medication, as calcium can interfere with antibiotic absorption.
• Grapefruit and grapefruit juice should be avoided as they may influence the effectiveness of these antibiotics due to their impact on liver enzymes.
• Alcohol consumption should be minimized or avoided as it may increase the risk of gastrointestinal side effects and potential liver issues.
• High-fiber foods like whole grains, legumes, and leafy vegetables may reduce the absorption of these antibiotics, so it's best to take the medication on an empty stomach.
• Caffeinated beverages such as coffee and tea may increase the likelihood of side effects, especially nervous system-related symptoms.
• Chocolate contains compounds that can potentially interact with antibiotics, so it's best to avoid it during the treatment period.
• Certain foods rich in vitamin K, like leafy green vegetables, can interfere with the action of polymyxin B, affecting its anticoagulant properties.
• Follow a balanced diet to maintain overall health and support the body's recovery during antibiotic treatment.

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Neomycin, nystatin, polymyxin B sulphate capsules should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It's crucial not to expose the capsules to heat or direct sunlight, as this can compromise their effectiveness. Proper disposal of any unused or expired medication is essential; do not flush or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the capsules out of children's reach to prevent accidental consumption.

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Following are the quick tips for Neomycin, Nystatin, Polymyxin B Sulphate Capsule:

• Take the capsule as directed by your doctor, usually 2-4 times a day.
• Swallow the capsule whole with a full glass of water to ensure proper absorption.
• Take the capsule on an empty stomach, at least 1 hour before or 2 hours after meals.
• Maintain a consistent dosing schedule to ensure the best treatment outcome.
• Avoid missing doses; if you miss a dose, take it as soon as you remember, unless it's almost time for the next dose.
• Do not double the dose to catch up, as it may increase the risk of side effects.
• Store the capsules at room temperature, away from moisture and light.

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