Prednisynth (0.5/0.2%) 10ml Eye Suspension

Chloramphenicol and Prednisolone eye drops have a synergistic mechanism of action to treat eye infections and reduce inflammation. Chloramphenicol primarily acts as a bacteriostatic antibiotic, inhibiting protein synthesis in susceptible bacteria by binding to the 50S subunit of the bacterial ribosome, which effectively halts the growth and multiplication of bacteria. Prednisolone, on the other hand, is a corticosteroid that reduces inflammation by inhibiting the production and release of inflammatory mediators. It suppresses the activation of immune cells, downregulates the expression of inflammatory genes, and reduces the production of pro-inflammatory cytokines, thereby alleviating the redness, swelling, and discomfort associated with ocular inflammation. When used together, Chloramphenicol controls the infection, while Prednisolone mitigates the inflammatory response, providing effective relief for various eye conditions.

Antibiotic, Corticosteroid.

Drop

The following are the uses of Chloramphenicol, Prednisolone Eye Drop:

• Used for treating eye infections caused by bacteria.
• Used to reduce inflammation and redness in the eye.
• Used for eye conditions such as conjunctivitis, uveitis, and post-surgical eye inflammation.
• Used to prevent and treat eye infections after eye surgery or injury.
• Used to alleviate eye pain and discomfort associated with inflammation.
• Used to manage allergic eye conditions, reducing itching and swelling.
• Used to prevent potential vision loss in specific eye conditions.

In the case of an overdose of Chloramphenicol and Prednisolone Eye Drops, it is important to seek medical advice promptly. While rare, an overdose can lead to increased eye pressure and potential vision issues. Symptoms may include blurred vision, eye pain, or redness. If you suspect an overdose, contact a healthcare professional immediately for guidance and further instructions. They will be able to provide the necessary support and ensure appropriate treatment to address any potential side effects.

In the case of a missed dose of Chloramphenicol and Prednisolone Eye Drops, it is important to administer the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one. If you miss several doses, contact your healthcare provider for advice, as they may recommend adjusting the dosage or provide further instructions to ensure the effectiveness of the treatment.

To use Chloramphenicol and Prednisolone Eye Drops, gently squeeze the prescribed number of drops into the affected eye(s) as directed by your healthcare provider, typically 1-2 drops, up to 4 times a day, or as instructed, while avoiding touching the dropper tip to any surface to prevent contamination.

Here are the conditions or situations when Chloramphenicol and Prednisolone Eye Drops should not be used:

• Avoid using these eye drops if you have a known allergy or sensitivity to Chloramphenicol, Prednisolone, or any other ingredients in the eye drop formulation.
• Do not use these eye drops if you have a fungal, viral, or mycobacterial infection in the eye(s), as these medications are not effective against such infections.
• Not suitable for individuals with a history of corneal ulcers or perforation, especially if caused by herpes simplex keratitis.
• Contraindicated in patients with certain types of eye infections, such as vaccinia, varicella, or tuberculosis.
• Avoid using these eye drops if you have a history of glaucoma or increased intraocular pressure, as they can exacerbate these conditions.
• Not recommended for individuals with untreated eye infections caused by bacteria, fungi, or viruses.
• Do not use these eye drops if you have recently had eye surgery, such as cataract surgery, unless specifically instructed by your doctor.

The side effects of Chloramphenicol, Prednisolone Eye Drops may include:

• Eye irritation or burning sensation
• Blurred vision or visual disturbances
• Increased eye pressure (glaucoma)
• Allergic reactions such as redness, itching, or swelling of the eyes
• Eye discharge or excessive tearing
• Sensitivity to light (photophobia)
• Delayed wound healing in the eye
• Increased risk of eye infections

Following are the precautions and warnings for Chloramphenicol, Prednisolone Eye Drops:

• Do not use these eye drops if you are allergic to any of their ingredients, including chloramphenicol or prednisolone.
• These eye drops are not recommended for long-term use due to potential side effects; use only as directed by your doctor.
• Do not wear contact lenses while using these eye drops unless advised otherwise by your eye specialist.
• Inform your doctor if you have any pre-existing eye conditions, such as glaucoma, eye infections, or injuries.
• Discontinue use and seek medical attention if you experience severe eye pain, changes in vision, or increased redness or swelling of the eye.
• These eye drops may cause temporary blurred vision; do not drive or operate machinery until your vision is clear.
• Pregnant and breastfeeding women should consult their doctor before using these eye drops.

Following are the drug interactions for Chloramphenicol, Prednisolone Eye Drops:

• The combination with other topical ophthalmic medications containing preservatives may increase the risk of corneal toxicity.
• Using other corticosteroid medications simultaneously may increase the risk of systemic side effects.
• Chloramphenicol may interact with other antibiotics, potentially reducing its effectiveness.
• Concomitant use with other immunosuppressants can enhance immunosuppression.
• The effect of oral anticoagulants may be altered, requiring close monitoring.
• Caution is advised when using with other anti-inflammatory drugs, as it may increase the risk of ocular hypertension.
• Certain drugs metabolized by the liver may have increased blood levels when used with Chloramphenicol.

Following are the food interactions for Chloramphenicol, Prednisolone Eye Drop:

• Avoid consuming grapefruit or grapefruit juice as it may lead to increased drug levels in the body, potentially causing adverse effects.
• Alcohol consumption is generally not recommended as it can reduce the effectiveness of the eye drops and may cause temporary blurred vision.
• Avoid consuming excessive amounts of vitamin A-rich foods like liver, sweet potatoes, and carrots, as this medication already contains a form of vitamin A.
• Limit caffeine intake from coffee, tea, or energy drinks as it may reduce the effectiveness of the eye drops.
• Avoid spicy foods as they can irritate the eyes and potentially worsen eye conditions.
• Maintain a balanced diet rich in antioxidants, such as leafy greens, berries, and nuts, to support eye health and potentially enhance the effects of the medication.
• Stay hydrated by drinking plenty of water to maintain overall eye comfort and moisture.
• Consider limiting the consumption of high-sodium foods as they can contribute to fluid retention and potentially impact eye pressure.

Chloramphenicol and Prednisolone Eye Drops should be stored in a clean, dry area at room temperature, ideally between 68°F and 77°F (20°C and 25°C). Keep the eye drops in their original packaging, tightly sealed, to maintain sterility and prevent contamination. Avoid exposing the medication to direct sunlight or freezing temperatures as this can degrade its quality. Always check the expiration date before using the eye drops, and never use them if they have expired. When it's time to discard the eye drops, do not pour them down the sink or flush them; instead, follow local guidelines for the safe disposal of medications to protect the environment. Keep the eye drops out of children's reach to prevent accidental exposure.

Following are the quick tips for Chloramphenicol, Prednisolone Eye Drop:

• Wash your hands before applying the eye drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and instill the prescribed number of drops into the eye.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• Close your eyes gently and apply light pressure to the inner corner of the eye for a few seconds to minimize drainage.
• If using other eye medications, wait at least 5 minutes before applying the next one to ensure proper absorption.
• Store the eye drops at room temperature, away from direct sunlight and heat.
• Do not share your eye drops with others to prevent the spread of infection.