Predsin (5/2mg) 10ml Eye Drops

Chloramphenicol and Prednisolone eye drops have distinct mechanisms of action. Chloramphenicol primarily acts as a broad-spectrum bacteriostatic antibiotic. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing the formation of peptide bonds and subsequent protein assembly. This action effectively halts the growth and multiplication of susceptible bacteria, making it useful for treating bacterial eye infections. Prednisolone, on the other hand, is a corticosteroid that exerts its effects by binding to cytoplasmic glucocorticoid receptors. Upon binding, the activated complex translocates to the nucleus, where it regulates gene expression. This leads to the suppression of various inflammatory mediators, reducing inflammation, and providing relief from associated symptoms in the eye.

Chloramphenicol, Prednisolone

Antibiotic, Steroid.

drop

The following are the uses of Chloramphenicol, Prednisolone Drop:

• Used for treating bacterial eye infections
• Used to reduce inflammation and redness in the eye
• Used for conditions such as conjunctivitis and blepharitis
• Used for eye injuries or post-surgery eye inflammation
• Used to prevent infection and promote healing
• Used for allergic reactions causing eye irritation
• Used for reducing pain and discomfort in the eye
• Used as an adjunct to other eye treatments

In the case of an overdose of Chloramphenicol or Prednisolone Drops, the individual may experience severe adverse effects. Symptoms can include nausea, vomiting, and in extreme cases, seizures or organ damage. Prompt medical intervention is vital, and individuals should seek emergency care immediately. Treatment may involve gastric lavage, administration of activated charcoal, and supportive care to manage symptoms and prevent further complications. It is important to act swiftly to mitigate potential harm.

In the case of a missed dose of Chloramphenicol, apply the eye drops as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra drops to make up for the missed dose. For Prednisolone Drop, if you miss a dose, administer it as soon as you can. If it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use extra drops to compensate for the missed dose.

To use Chloramphenicol and Prednisolone eye drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and hold the dropper tip close to, but not touching, your eye. Squeeze the prescribed number of drops into the pocket, then gently close your eyes and apply light pressure to the inner corner of the eye for 1-2 minutes to prevent the drops from draining out.

Here are the conditions or situations when Chloramphenicol and Prednisolone eye drops should not be used:

• Do not use if you are allergic to Chloramphenicol, Prednisolone, or any other similar medications.
• Avoid using these eye drops if you have a current or recent fungal, viral, or mycobacterial infection in the eye(s).
• Not suitable for individuals with a history of hypersensitivity or allergic reactions to any of the ingredients in the eye drops.
• Should not be used if you have a current or recent herpes simplex infection in the eye(s).
• Contraindicated in patients with a history of corneal ulcers or perforation caused by viral infections.
• Do not use if you have or suspect a corneal abrasion or any other type of eye injury.
• Not recommended for individuals with a history of glaucoma or increased intraocular pressure.
• Avoid using these eye drops if you have or suspect a bacterial infection in the eye(s) caused by organisms resistant to Chloramphenicol.
• Should not be used in patients with a history of ocular surgery, including cataract surgery, within the last 6 months.
• Do not use if you have a current or recent eye infection caused by vaccinia or varicella viruses.
• Not suitable for individuals with a history of corneal ulcers or perforation not caused by infections.
• Avoid using these eye drops if you have a history of tuberculosis of the eye.
• Should not be used in patients with a history of hypersensitivity to any other corticosteroid medications.
• Do not use if you have or suspect a fungal, mycobacterial, or parasitic infection in the eye(s).
• Contraindicated in individuals with a history of untreated bacterial eye infections.

The side effects of Chloramphenicol and Prednisolone Eye Drops may include:

• Stinging or burning sensation in the eyes
• Itchy or watery eyes
• Blurred vision or other visual disturbances
• Increased eye pressure (especially with prolonged use)
• Allergic reactions such as redness, swelling, or itching of the eyelids
• Sensitivity to light
• Dry eyes or eye discomfort
• Increased risk of eye infections with prolonged use

Following are the precautions and warnings for Chloramphenicol and Prednisolone Drops:

• Not suitable for patients with hypersensitivity to chloramphenicol, prednisolone, or any other component of the formulation.
• Prolonged use may lead to fungal or bacterial superinfections, including opportunistic infections.
• Avoid long-term use as chloramphenicol may cause bone marrow suppression, including aplastic anemia, which can be life-threatening.
• Use with caution in patients with pre-existing glaucoma or ocular hypertension, as prednisolone may increase intraocular pressure.
• Should not be used in viral or fungal eye infections, as corticosteroids may worsen these conditions.
• Patients should avoid wearing contact lenses during treatment to prevent irritation and potential contamination.
• May cause temporary blurred vision; avoid driving or operating heavy machinery immediately after application.
• If no improvement is seen within a few days, or symptoms worsen, discontinue use and consult a healthcare provider.
• Use during pregnancy and breastfeeding should be based on a doctor’s recommendation, weighing the potential risks and benefits.
• Do not use in children without medical supervision, as the systemic absorption of corticosteroids may affect growth and development.

Following are the drug interactions for Chloramphenicol, Prednisolone Drop:

• Chloramphenicol may reduce the effect of aminoglycoside antibiotics, such as gentamicin, when used together.
• Concomitant use with other immunosuppressants or corticosteroids can increase the risk of infection and mask the signs of infection.
• Chloramphenicol can prolong the effects of anticoagulants like warfarin, requiring close monitoring of blood clotting time.
• It may reduce the effectiveness of oral contraceptives, so alternative birth control methods are advised.
• Caution is needed with drugs metabolized by the liver, as Chloramphenicol can inhibit liver enzymes, leading to increased levels of these medications.
• The use of live vaccines is not recommended during treatment due to the risk of severe infection.
• Prednisolone can increase the risk of gastrointestinal bleeding when combined with nonsteroidal anti-inflammatory drugs (NSAIDs).

Following are the food interactions for Chloramphenicol, Prednisolone Eye Drops:

• It is advisable to avoid consuming grapefruit and grapefruit juice while using these eye drops, as grapefruit can interfere with the metabolism of certain medications, potentially leading to increased drug levels in the body.
• Alcohol consumption should be limited or avoided as it may temporarily decrease the effectiveness of the eye drops by altering blood flow to the eye area.
• Spicy foods may cause a burning sensation or irritation in the eyes, especially if you have a pre-existing eye condition. It's best to avoid spicy foods while using these eye drops.
• Caffeine-rich beverages like coffee and energy drinks might increase eye pressure, so moderation is key to minimizing this potential interaction.
• Dairy products, especially those high in fat, may form a layer on the eye surface, potentially affecting the absorption of the eye drops. Consider reducing dairy intake for optimal medication absorption.
• Foods rich in vitamin K, such as leafy green vegetables, can potentially interact with Prednisolone, affecting its anticoagulant properties. Consume these foods in moderation.
• It's generally recommended to maintain a balanced diet, ensuring adequate hydration for optimal eye health and medication effectiveness.
• There are no specific food restrictions with Chloramphenicol, but a healthy diet supports overall eye health.

Chloramphenicol and Prednisolone eye drops should be stored in a clean, dry area at room temperature, typically between 68°F and 77°F (20°C and 25°C). Keep the bottle tightly sealed and protected from light, as exposure to light can degrade the medication. It is crucial to maintain the integrity of the eye drops by ensuring the dropper tip does not touch any surfaces, including the eye or skin, to prevent contamination. Once the bottle is opened, write down the date and discard any remaining solution after the specified period, usually 4 weeks, as it may become less effective or unsafe for use. Proper disposal methods should be followed, such as returning the medication to a pharmacy or a designated medicine take-back program to ensure environmental safety. Keep the medication out of the reach of children and pets to prevent accidental ingestion.

Following are the quick tips for this:

• Administer eye drops as directed by your doctor, usually 1-2 drops into the affected eye(s) every 2-4 hours.
• Wash your hands before applying the drops to ensure cleanliness.
• Tilt your head back, gently pull down your lower eyelid, and apply the drops into the pocket formed.
• Close your eyes gently after administering the drops and apply light pressure to the inner corner of the eye to minimize drainage.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If using other eye medications, wait at least 5 minutes before applying the next medication.
• Store the eye drops properly and check the expiration date regularly.
• Wash your hands thoroughly before using the eye drops.
• Tilt your head back, gently pull down your lower eyelid, and apply the prescribed number of drops into the pocket formed.
• Close your eyes gently and apply light pressure to the inner corner of the eye for about 1-2 minutes to prevent the medication from draining out.
• If you use other eye medications, wait at least 5-10 minutes before applying the next one to ensure proper absorption.
• Avoid wearing contact lenses while using the eye drops unless your doctor advises otherwise.
• Do not touch the dropper tip to any surface, including your eye, to maintain sterility.
• Store the eye drops at room temperature and away from direct sunlight or extreme temperatures.