Prefrin-A (1.20/1mg) 10ml Eye Drops

Phenylephrine, a sympathomimetic amine, acts by directly stimulating alpha-adrenergic receptors in the arterioles of the nasal mucosa, leading to vasoconstriction and decreased blood flow, thereby reducing nasal congestion. On the other hand, Pyrilamine, an ethanolamine derivative, exerts its effect by competitively blocking histamine H1 receptors, which inhibits the actions of histamine released during allergic reactions. This blockage helps to alleviate symptoms such as itching, sneezing, and rhinorrhea associated with allergic responses.

Antihistamine, Decongestant

Solution

The following are the uses of Phenylephrine, Pyrilamine (Maleate) Drop:

• Used for relieving symptoms of the common cold and hay fever, such as runny nose, sneezing, and itchy, watery eyes.
• Used for providing temporary relief from nasal congestion and sinus pressure.
• Used for helping reduce inflammation and swelling in the nasal passages.
• Used for treating symptoms of allergic reactions, including itchy, watery eyes, and runny nose.
• Used for providing comfort during respiratory illnesses.
• Used for alleviating discomfort caused by sinus congestion.
• Used for supporting clearer breathing by reducing nasal congestion.

To be used as per doctor's instructions

In the case of an overdose of Phenylephrine and Pyrilamine Maleate Drops, symptoms may include severe drowsiness, confusion, rapid heartbeat, hallucinations, and difficulty breathing. Promptly seek medical assistance if you or someone else has ingested an excessive amount. Treatment for overdose may involve supportive care, such as administering intravenous fluids and ensuring the patient's airway is clear and unobstructed. It is crucial to provide accurate information about the medication and the estimated amount ingested.

In the case of a missed dose of Phenylephrine, Pyrilamine (Maleate) Drops, administer the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one. If you're unsure or have any concerns, contact your healthcare provider for guidance on managing missed doses.

To administer Phenylephrine, Pyrilamine (Maleate) Drops, gently squeeze the prescribed number of drops into the ear as directed by your healthcare professional. Ensure that you tilt your head to the side and keep it still for a brief period to allow the medication to flow down into the ear canal.

Here are the conditions or situations when Phenylephrine and Pyrilamine Maleate Drops should not be used:

• Do not use if you have an allergy or hypersensitivity to Phenylephrine, Pyrilamine Maleate, or any other ingredients in the medication.
• Avoid using these drops if you have narrow-angle glaucoma or a history of this condition.
• Should not be used if you have severe high blood pressure or cardiovascular disease.
• Contraindicated in individuals with difficulty urinating due to an enlarged prostate gland.
• Not suitable for those who have taken a monoamine oxidase inhibitor (MAOI) in the last 14 days.
• Do not use if you have a seizure disorder or a history of seizures.
• Avoid using these drops if you have a stomach ulcer or a blockage in your intestines.
• Should not be administered to infants or children under the age of 2 years without medical advice.

The side effects of Phenylephrine, Pyrilamine (Maleate) Drops may include:

• Drowsiness or fatigue
• Dry mouth, nose, or throat
• Headache
• Dizziness or vertigo
• Nausea or upset stomach
• Nervousness or restlessness
• Difficulty in urination
• Increased heart rate

Here are the precautions and warnings for Phenylephrine, Pyrilamine (Maleate) Drops:

• Do not use this medication if you have a known allergy to phenylephrine, pyrilamine maleate, or any other ingredients in the drops.
• Individuals with high blood pressure, heart disease, diabetes, thyroid problems, or glaucoma should use with caution and under medical supervision.
• Avoid using this medication if you are taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days.
• Do not exceed the recommended dosage, as this may lead to serious side effects, especially in children.
• Patients with prostate problems or difficulty urinating should exercise caution and consult a healthcare professional before use.
• If symptoms persist, worsen, or are accompanied by fever, consult a doctor immediately.
• This medication may cause drowsiness and affect your ability to drive or operate machinery; avoid such activities until you know how the medication affects you.

Following are the drug interactions for Phenylephrine, Pyrilamine (Maleate) Drop:

• Alcohol and other CNS depressants may increase the risk of drowsiness and sedation when taken with this medication.
• Antihistamines in this combination may reduce the effectiveness of gastrointestinal anticholinergics.
• Phenylephrine may interact with beta-blockers, increasing blood pressure.
• Monoamine oxidase inhibitors (MAOIs) should not be used concurrently due to the risk of hypertensive crisis.
• Tricyclic antidepressants may enhance the anticholinergic effects of pyrilamine.
• The medication may reduce the antihypertensive effect of certain drugs, such as beta-blockers and methyldopa.
• Concomitant use with other sympathomimetic agents may lead to an increased risk of cardiovascular side effects.
• Caution is advised when combining with other medications that have a drying effect, as it may exacerbate dryness in the mouth, nose, and throat.

Following are the food interactions for Phenylephrine, Pyrilamine (Maleate) Drops:

• Avoid consuming alcohol with this medication as it may increase the risk of drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the medication, potentially leading to increased side effects.
• Caffeine-containing products like coffee, tea, or energy drinks may increase blood pressure and heart rate, especially when combined with Phenylephrine.
• Chocolate, particularly dark chocolate, contains compounds that can inhibit the action of Pyrilamine, potentially reducing its effectiveness.
• Foods high in sugar or salt may interact with the medication's effects on blood pressure and heart rate, so monitor intake.
• Avoid eating large meals immediately after taking the drops, as it may affect the absorption of the medication.
• Dairy products may potentially interact with Pyrilamine, leading to reduced absorption, so consider spacing out the intake of dairy and medication.

Phenylephrine, Pyrilamine (Maleate) Drops should be stored at room temperature, preferably between 68°F and 77°F (20°C and 25°C), in a dry place away from light and moisture. Keep the bottle tightly closed when not in use to maintain its integrity. Do not freeze the medication as it may affect its potency. Dispose of any unused or expired medication responsibly by following local guidelines or consulting a pharmacist. Never pour the drops down the sink or toilet, as this can contaminate the environment. Keep the medication away from children and pets to prevent accidental ingestion.

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Following are the quick tips for Phenylephrine, Pyrilamine Maleate Drops:

• Consult a doctor or pharmacist before use, especially if you have any medical conditions or are taking other medications.
• Use the dropper provided to administer the correct dose, following the prescribed dosage instructions.
• Administer the drops directly into the mouth, preferably under the tongue for better absorption.
• Avoid touching the dropper tip to any surface to prevent contamination.
• If you miss a dose, take it as soon as you remember, unless it's close to the time for your next dose.
• Store the drops at room temperature, away from direct sunlight and moisture.
• Do not use if the solution changes color or becomes cloudy.