Preglan-E2 (3mg) 1 Tablet

Dinoprostone, also known as prostaglandin E2 (PGE2), primarily exerts its effects through binding and activating specific prostaglandin E receptors, mainly EP2 and EP4 receptors, which are G-protein coupled receptors. When administered, Dinoprostone stimulates these receptors, leading to a cascade of intracellular events. This activation results in the relaxation of smooth muscle, particularly in the uterus and cervix, by increasing intracellular cyclic adenosine monophosphate (cAMP) levels. The rise in cAMP leads to the activation of protein kinase A (PKA) and subsequent phosphorylation of target proteins, causing smooth muscle relaxation. This mechanism is crucial for cervical ripening and the induction of uterine contractions, making Dinoprostone effective in various obstetric and gynecological applications.

Prostaglandin E1 analog

Tablet

The following are the uses of Dinoprostone 3mg Tablet:

• Used for inducing labor by ripening the cervix and promoting contractions, making it easier for the baby to move through the birth canal.
• Used for softening and dilating the cervix during the early stages of labor to facilitate a smoother delivery.
• Used for managing missed or incomplete miscarriages, helping to empty the uterus and avoid surgical intervention.
• Used for treating postpartum hemorrhage by stimulating uterine contractions and reducing bleeding.
• Used for ripening the cervix prior to certain gynecological procedures or surgeries, making the process safer and more efficient.
• Used for inducing labor in cases of fetal demise, providing a controlled and supportive environment for delivery.
• Used for maintaining cervical dilation during pregnancy to prevent preterm labor or address specific medical conditions.

In the case of an overdose of Dinoprostone 3mg Tablets, it is important to recognize the potential symptoms, which may include severe abdominal pain, diarrhea, nausea, and vomiting. If an overdose is suspected, seek medical assistance promptly. Treatment for overdose may involve supportive care, such as monitoring vital signs and managing symptoms. It is crucial to contact a healthcare professional or a poison control center for guidance on managing the specific effects of the overdose.

In the case of a missed dose of Dinoprostone 3mg Tablet, it is essential to consult your healthcare provider for guidance. They will be able to advise you on the best course of action, as the management of missed doses may vary depending on the reason for the prescription and your individual medical condition. Generally, if you realize you've missed a dose, take it as soon as possible, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one without medical advice.

To administer the Dinoprostone 3mg Tablet, insert the tablet vaginally, following the prescribed dosage instructions provided by your healthcare professional, ensuring a controlled and safe delivery method.

Following are the conditions or situations when Dinoprostone 3mg Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Dinoprostone or other prostaglandins.
• Contraindicated in women who are pregnant, especially if the pregnancy is at term or near term.
• Not recommended for use in patients with severe asthma or a history of severe asthma.
• Should be avoided in patients with active peptic ulcer or a history of gastrointestinal disorders.
• Contraindicated in cases of undiagnosed vaginal bleeding or genital tract abnormalities.
• Not suitable for individuals with a history of cardiovascular diseases or conditions like heart disease, hypertension, or stroke.
• Should not be used if there is an intrauterine infection or inflammation present.
• Contraindicated in women with a history of C-section or other uterine surgery.
• Not recommended for use in cases of severe anemia or blood disorders.

The side effects of Dinoprostone 3mg Tablet may include:

• Uterine contractions
• Nausea and vomiting
• Diarrhea
• Abdominal pain or cramps
• Fever
• Chills or shivering
• Increased heart rate
• Uterine hyperstimulation
• Vaginal bleeding

Following are the precautions and warnings for Dinoprostone 3mg Tablet:

• This medication is intended for vaginal use only and should never be taken by mouth or applied elsewhere on the body.
• Dinoprostone should be used with caution in patients with a history of asthma, as it may cause bronchospasm or aggravate existing asthma symptoms.
• Not recommended for individuals with a history of cardiovascular disease, as it can lead to increased heart rate, blood pressure changes, and other cardiovascular complications.
• Patients with kidney or liver disease should use this medication with caution, as it may require dosage adjustments.
• May cause uterine contractions and should be used with caution in women with conditions like uterine fibroids or pelvic inflammatory disease.
• Pregnant women should only use this medication under strict medical supervision, as it can induce labor and may have adverse effects on the fetus.
• Breastfeeding women should exercise caution and consult a healthcare professional before using this medication, as it may pass into breast milk.
• Allergic reactions are possible; seek medical attention immediately if you experience symptoms like rash, itching, swelling, or difficulty breathing.

Following are the drug interactions for Dinoprostone 3mg Tablet:

• It should not be used with other prostaglandins or oxytocic drugs due to the risk of increased uterine activity and potential adverse effects.
• Dinoprostone may interact with NSAIDs, such as ibuprofen, as these drugs can inhibit the synthesis of prostaglandins, potentially reducing the effectiveness of Dinoprostone.
• Use with magnesium sulfate is not recommended, as it may lead to excessive uterine contractions and fetal distress.
• Corticosteroids can decrease the effectiveness of Dinoprostone by inhibiting prostaglandin synthesis.
• Anticoagulants like heparin may increase the risk of bleeding when used with Dinoprostone, especially when administered vaginally.
• Certain antibiotics, such as erythromycin, may increase the levels of Dinoprostone, potentially leading to enhanced effects and side effects.
• Drugs that induce labor, like oxytocin, should be used cautiously with Dinoprostone, as the combination may result in excessive uterine stimulation.

Following are the food interactions for Dinoprostone 3mg Tablet:

• It is advisable to avoid grapefruit and grapefruit juice during treatment with Dinoprostone as these may increase the drug's effects and side effects.
• Alcohol consumption should be limited or avoided as it can increase the risk of gastrointestinal side effects like nausea and stomach pain.
• Caffeine intake should be monitored as it may influence the absorption and metabolism of the medication.
• Spicy foods are best avoided as they can irritate the gastrointestinal tract and potentially worsen any existing inflammation.
• Dairy products may not be well-tolerated during Dinoprostone use due to their potential to increase mucus production and gastrointestinal discomfort.
• Foods high in fat may delay the absorption of Dinoprostone, leading to reduced effectiveness.
• Sugary foods and beverages should be consumed in moderation as they can impact the overall health and healing process.
• It is generally recommended to maintain a balanced diet and stay well-hydrated during the course of treatment.

Dinoprostone 3mg tablets should be stored in a secure and dry location, preferably in a medicine cabinet, away from heat, moisture, and direct sunlight. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity and effectiveness. It is crucial not to store the medication in the bathroom or kitchen, as these areas can expose the tablets to temperature fluctuations and humidity. Always check the expiration date, and if the medication has expired, do not use it and dispose of it carefully. Proper disposal methods are essential; do not flush the tablets or throw them into the trash without consulting a pharmacist or healthcare professional for guidance on safe disposal practices. Keep the medication out of children's reach to prevent accidental ingestion, ensuring the safety of your household.

Following are the quick tips for Dinoprostone 3mg Tablet:

• Consult your doctor before using this medication for inducing labor or cervical ripening.
• Follow the prescribed dosage and duration provided by your healthcare professional.
• This medication is typically used in a hospital setting under medical supervision.
• Inform your doctor about your medical history, especially if you have asthma or cardiovascular conditions.
• Do not use this medication if you are allergic to dinoprostone or similar medications.
• Side effects may include nausea, vomiting, diarrhea, and abdominal pain; report severe or persistent symptoms.
• Store the medication properly and keep it out of reach of children.