Prens (1.0%) 5ml Eye Suspension

Prednisolone and Prednisone eye drops primarily exert their effects by acting as synthetic corticosteroids. When administered into the eye, these medications bind to glucocorticoid receptors in various ocular tissues, including the cornea, conjunctiva, and uvea. This binding triggers a series of intracellular events that lead to the suppression of inflammation and immune responses. Prednisolone and Prednisone inhibit the production and release of inflammatory mediators such as prostaglandins, leukotrienes, and cytokines, thereby reducing redness, swelling, and irritation associated with ocular inflammation. They also stabilize cell membranes, inhibit the migration of inflammatory cells to the site of inflammation, and decrease capillary permeability, contributing to their anti-inflammatory and immunosuppressive actions in the eye.

Corticosteroid.

Drop

The following are the uses of Prednisolone, Prednisone Eye Drop:

• Used for reducing inflammation and treating various eye conditions such as allergic conjunctivitis, uveitis, and eye injuries.
• Used for managing eye redness, itching, and swelling caused by allergies.
• Used for treating inflammation of the uvea, the middle layer of the eye.
• Used for promoting healing after eye surgeries or injuries.
• Used for providing relief from eye discomfort and irritation.
• Used for preventing further damage and improving eye health.
• Used for controlling the immune response in the eye to reduce inflammation.

In the case of an overdose of Prednisolone or Prednisone Eye Drops, it is important to remain calm and take immediate action. If ingested orally, rinse the mouth with water to remove any remaining medication. Do not induce vomiting unless advised by a healthcare professional. Monitor for symptoms such as rapid heartbeat, dizziness, or blurred vision, and seek medical assistance promptly. A healthcare provider may administer appropriate treatment to manage the overdose and prevent potential complications.

In the case of a missed dose of Prednisolone or Prednisone Eye Drops, it is important to administer the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. However, if you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule to ensure the best treatment outcome.

To administer Prednisolone, Prednisone Eye Drops, gently tilt your head back, pull down the lower eyelid to create a pocket, and hold the dropper close to the eye, dispensing the prescribed number of drops into the pocket while looking up, then gently close your eye and blink to distribute the medication evenly.

Here are the conditions and situations when Prednisolone or Prednisone Eye Drops should not be used:

• Avoid using if you have a known allergy to Prednisolone, Prednisone, or any other ingredients in the eye drops.
• Do not use if you have a fungal, viral, or tubercular infection in the eye(s), unless it is being treated with other appropriate medication.
• Not suitable for individuals with herpes simplex or vaccinia (cowpox) infections of the eye.
• Should not be used if you have a history of glaucoma or raised intraocular pressure.
• Avoid using if you have corneal ulcers or perforations.
• Not recommended for individuals with recent eye surgery, unless advised by an ophthalmologist.
• Do not use if you have untreated bacterial, fungal, or viral infections in the eye.
• Avoid using Prednisolone or Prednisone Eye Drops if you have a history of ocular herpes simplex.

The side effects of Prednisolone and Prednisone Eye Drops may include:

• Increased eye pressure (glaucoma)
• Blurred vision or visual disturbances
• Eye discomfort or irritation
• Stinging or burning sensation in the eye
• Itching or redness of the eye
• Watery eyes
• Increased sensitivity to light

Following are the precautions and warnings for Prednisolone, Prednisone Eye Drops:

• Do not use these eye drops if you have a known allergy to Prednisolone, Prednisone or any other ingredients in the formulation.
• If you have a history of eye infections, inform your doctor before using these drops, as they can mask or worsen existing infections.
• These eye drops may cause blurred vision temporarily, so avoid driving or operating machinery until your vision is clear.
• Prolonged use of corticosteroid eye drops can lead to increased intraocular pressure, glaucoma, and cataracts. Regular eye pressure checks are necessary during treatment.
• If you have a history of herpes simplex keratitis, these drops may cause a reactivation of the virus. Use with caution and regular monitoring.
• Contact lens wearers should remove lenses before using the eye drops and wait at least 15 minutes after administration before reinserting them.
• Children and elderly patients should use these drops under strict medical supervision due to potential side effects.
• If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before using these eye drops.

Following are the drug interactions for Prednisolone, Prednisone Eye Drop:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding when used with prednisolone.
• Anticoagulants like warfarin can have their effects enhanced by prednisolone, requiring close monitoring of coagulation parameters.
• Combining with antidiabetic medications may lead to increased blood glucose levels, necessitating adjustments in antidiabetic treatment.
• The metabolism of certain medications, such as CYP3A4 substrates, can be altered by prednisolone, potentially affecting their effectiveness.
• Live vaccines should be avoided during and shortly after prednisolone treatment due to potential reduced vaccine efficacy and increased risk of infection.
• Using prednisolone with other immunosuppressants can increase the risk of infection and may require dosage adjustments.
• There may be an increased risk of adverse cardiovascular events when prednisolone is used with thiazide diuretics or other cardiovascular medications.

Following are the food interactions for Prednisolone, Prednisone Eye Drop:

• Prednisolone may interact with high-fat meals, potentially increasing the risk of elevated blood glucose levels. It is advisable to use caution when consuming fatty foods.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of the drug, leading to increased drug levels and potential side effects.
• Alcohol consumption should be limited as it can increase the risk of gastrointestinal issues and may also impair wound healing.
• Avoid caffeine-rich foods and beverages as they can potentially increase the risk of insomnia and restlessness.
• Foods high in vitamin K, like leafy greens, should be consumed with caution as Prednisolone can affect blood clotting.
• Salt and salty foods may need to be reduced as Prednisolone can cause fluid retention.
• Consuming a balanced diet is essential, especially focusing on calcium-rich foods, to support bone health, as prolonged use may impact bone density.
• Certain herbs like St. John's Wort might affect the drug's effectiveness, so consult a healthcare professional before taking any herbal supplements.

Prednisolone and Prednisone Eye Drops require careful storage and disposal to maintain their effectiveness and ensure safety. Store the eye drops in a cool, dry place, preferably at room temperature, ensuring they are kept away from direct sunlight and heat sources like radiators or stoves, as these can degrade the medication. Keep the bottle tightly sealed in its original packaging to maintain sterility and prevent contamination. Always check the expiration date before use, and never use the drops after this date. When disposing of the eye drops, do not flush them down the toilet or pour them into drains. Contact your pharmacist or healthcare provider for guidance on proper disposal methods, and keep the medication out of reach of children to prevent accidental exposure or ingestion. Responsible storage and disposal practices help maintain the integrity of the medication and protect both users and the environment.

Following are the quick tips for Prednisolone, Prednisone Eye Drop:

• Wash your hands thoroughly before administering the eye drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and look up to create a pocket for the drop.
• Hold the dropper above your eye and gently squeeze one drop into the pocket, being careful not to touch your eye or eyelid.
• Close your eyes gently for 1-2 minutes to allow the drop to absorb.
• Avoid rubbing or applying pressure to your eye after administering the drop.
• If you use other eye medications, wait at least 5 minutes before applying the next one to prevent washout.
• Store the eye drops at room temperature, away from direct sunlight and heat.