Preterax (2/0.625mg) 10 Tablets

Perindopril 6.25 mg Tablet primarily works by inhibiting the angiotensin-converting enzyme (ACE). ACE is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor that increases blood pressure. By blocking the action of ACE, perindopril reduces the production of angiotensin II, leading to vasodilation (widening of blood vessels). This mechanism helps lower blood pressure by decreasing peripheral resistance and reducing the workload on the heart. Additionally, the reduced angiotensin II levels result in decreased aldosterone secretion, which in turn leads to increased excretion of sodium and water by the kidneys, further contributing to the blood pressure-lowering effect.

ACE inhibitor.

Tablet

The following are the uses of perindopril 625mg Tablet:

• Used for treating high blood pressure, helping to reduce strain on the heart and arteries.
• Used to manage heart failure, improving heart function and reducing associated symptoms.
• Used in the treatment of diabetic nephropathy, slowing the progression of kidney damage.
• Used to prevent cardiovascular events such as heart attacks or strokes in high-risk individuals.
• Used for lowering cholesterol levels, contributing to overall cardiovascular health.
• Used to alleviate angina symptoms by improving blood flow to the heart.
• Used for long-term management of cardiovascular conditions, often as part of a comprehensive treatment plan.
• Used to improve overall cardiovascular health and reduce the risk of future complications.

In the case of an overdose of Perindopril 625mg tablets, it is important to seek medical assistance promptly. Symptoms may include a severe drop in blood pressure, leading to dizziness and fainting. The overdose can also cause rapid and excessive potassium loss, affecting kidney function. Immediate treatment involves gastric lavage and supportive measures to maintain blood pressure and electrolyte balance. Prompt action is crucial to mitigate the potentially severe consequences of an overdose.

In the case of a missed dose of perindopril 625mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication and adjust the dosage if necessary. It is recommended to set reminders or alarms to help you remember to take your medication on time in the future.

To take perindopril 625mg Tablet, swallow the tablet whole with a full glass of water, preferably in the morning before a meal, following the instructions provided by your healthcare professional, and continue taking it as directed for the prescribed duration.

Following are the conditions/situations when Perindopril 625mg Tablet should not be used:

• Must not be used in patients with a known allergy to perindopril or any angiotensin-converting enzyme (ACE) inhibitors.
• Contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy.
• Should not be used during pregnancy, especially during the second and third trimesters.
• Not recommended for individuals with severe renal impairment or patients undergoing dialysis.
• Avoid in patients with bilateral renal artery stenosis or unilateral renal artery stenosis in a solitary kidney.
• Should not be used in patients with a history of hereditary angioedema.
• Contraindicated in patients with idiopathic or hereditary angioedema.

The side effects of perindopril 625mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Cough
• Headache
• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Impaired kidney function

Following are the precautions and warnings for Perindopril 625mg Tablet:

• Patients with a known allergy to perindopril or any other ACE inhibitor should not take this medication.
• It requires close monitoring and dosage adjustments for individuals with kidney disease or those undergoing dialysis.
• Caution is advised for patients with liver disease, as perindopril may affect liver function.
• Perindopril may cause dizziness or lightheadedness, especially when standing up; patients should rise slowly to prevent falls.
• Patients with a history of angioedema should exercise caution as this medication may increase the risk of this condition.
• It is not recommended for use during pregnancy or while breastfeeding without medical advice.
• This medication may cause hyperkalemia (high potassium levels); regular monitoring is necessary, especially in patients with kidney problems.
• Diabetic patients should be aware that perindopril can sometimes cause an increase in blood sugar levels.

Following are the drug interactions for perindopril 625mg Tablet:

• Perindopril can increase lithium levels, potentially leading to lithium toxicity. Close monitoring of lithium levels is necessary.
• Combined use with thiazide diuretics may increase the risk of hypotension and kidney function impairment. Blood pressure monitoring is essential.
• Concomitant use with potassium-sparing diuretics may elevate potassium levels, requiring regular monitoring.
• Perindopril may enhance the blood glucose-lowering effect, potentially causing hypoglycemia.
• NSAIDs can reduce the antihypertensive effect of perindopril and may increase the risk of kidney impairment.
• Perindopril may cause hyperkalemia when used with other medications that increase potassium levels, such as potassium supplements or angiotensin receptor blockers.
• The combination with immunosuppressants like cyclosporine may increase the risk of kidney damage and high potassium levels.

Following are the food interactions for Perindopril 625mg Tablet:

• Avoid excessive potassium-rich foods like bananas, oranges, and tomatoes as Perindopril can increase potassium levels in the body, potentially leading to hyperkalemia.
• Salt substitutes or low-sodium milk products containing potassium should be used cautiously as they may also increase potassium levels.
• Limit the consumption of alcohol as it can further lower blood pressure and increase the risk of dizziness and lightheadedness.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the blood levels of Perindopril, potentially leading to an increased risk of side effects.
• Avoid high-sodium foods as Perindopril is a blood pressure-lowering medication, and high sodium intake can reduce its effectiveness.
• Maintain a balanced diet, as Perindopril may cause a slight increase in blood sugar levels, particularly in diabetic patients.
• No significant food interactions are known to directly impact the absorption of Perindopril, but it's advisable to consult your doctor for personalized advice.

Perindopril 625mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent exposure to contaminants. It is crucial to avoid storing them in the bathroom or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets with caution; do not flush them or pour them down the drain. Consult your pharmacist or healthcare professional for appropriate disposal guidelines. Additionally, exercise vigilance by keeping the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Perindopril 625mg Tablet:

• Consult your doctor for personalized dosage instructions based on your medical condition.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole with a full glass of water, preferably in the morning before meals.
• Do not crush, chew, or break the tablet, as it may affect its effectiveness.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not share this medication with others, even if their symptoms appear similar.
• Regularly monitor your blood pressure and kidney function while on this medication.