PROACT SYP 25/120ML

Procaterol, the active ingredient in Procaterol Syrup/Suspension, is a beta-2 adrenergic agonist. Its primary mechanism of action involves stimulating beta-2 adrenergic receptors in the airways, which leads to relaxation of the smooth muscles surrounding the bronchial tubes. This relaxation results in bronchodilation, meaning it opens up the airways, allowing for easier breathing. Specifically, when Procaterol binds to the beta-2 receptors, it activates adenylate cyclase, leading to an increase in intracellular cyclic AMP (cAMP). Elevated cAMP levels then activate protein kinase A, which ultimately inhibits the phosphorylation of myosin light chains, causing smooth muscle relaxation and thus widening the airways.

Bronchodilator

Suspension

The following are the uses of Procaterol Syrup/Suspension:

• Used for the treatment of asthma, offering quick relief from symptoms.
• Used to prevent asthma attacks, especially when triggered by exercise.
• Effective in managing chronic obstructive pulmonary disease (COPD), improving breathing.
• Helps to relax and open airways, making breathing easier.
• Can be utilized in emergency situations to quickly alleviate severe asthma attacks.
• Provides long-term control of asthma symptoms, reducing frequency and severity.
• Assists in reducing inflammation in the airways, a common issue in asthma sufferers.

To be taken as per doctor's prescription

In the case of an overdose of Procaterol Syrup/Suspension, it is important to seek urgent medical care. Symptoms may include rapid heartbeat, tremors, and difficulty breathing. Do not induce vomiting unless advised by a healthcare professional. Quick action is vital, as prompt treatment can mitigate potential complications and ensure the best possible outcome for the patient. Always keep medications out of reach of children to prevent accidental ingestion.

In the case of a missed dose of Procaterol Syrup/Suspension, it is important to take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to get back on track with your medication regimen safely.

To use Procaterol Syrup/Suspension, shake the bottle well, measure the prescribed dose with a measuring device, and take it orally, following the dosage instructions provided by your healthcare professional, typically twice a day, with or without food, to ensure optimal absorption and effectiveness.

Following are the conditions/situations when Procaterol Syrup/Suspension should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Procaterol or any of the excipients in the formulation.
• Contraindicated in patients with a history of severe cardiovascular disorders, such as severe heart disease, irregular heart rhythms (arrhythmias), or recent heart attack.
• Not suitable for individuals with severe hypertension (high blood pressure).
• Should be avoided in patients with a history of seizures or epilepsy.
• Contraindicated in patients with an overactive thyroid (hyperthyroidism).
• Not recommended for individuals with a history of severe liver or kidney disease.
• Should not be used in patients with diabetes, as it may affect blood sugar control.
• Contraindicated during pregnancy and breastfeeding, unless the potential benefits outweigh the risks.
• Should not be used in children under 12 years of age due to insufficient safety and efficacy data.
• Not suitable for individuals with a history of lung diseases such as asthma, chronic bronchitis, or emphysema.

The side effects of Procaterol Syrup/Suspension may include:

• Rapid or irregular heartbeat (palpitations)
• Shakiness or tremors
• Headache
• Nausea and vomiting
• Dizziness or lightheadedness
• Restlessness or insomnia
• Dry mouth
• Muscle cramps

Following are the precautions and warnings for Procaterol Syrup/Suspension:

• This medication is intended for oral use only and should not be injected or inhaled.
• Patients with a history of cardiovascular diseases, high blood pressure, or irregular heart rhythms should use it with caution and under medical supervision.
• It may cause hypokalemia (low potassium levels); regular monitoring of potassium levels is recommended during prolonged treatment.
• Procaterol should be used with caution in patients with diabetes as it may increase blood sugar levels.
• Not recommended for individuals with known allergies to Procaterol or related medications.
• Avoid abrupt discontinuation of the medication to prevent worsening of symptoms; gradual tapering is advised.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as the risks and benefits should be carefully weighed.
• Always follow the prescribed dosage and duration as directed by your healthcare provider.

Following are the drug interactions for Procaterol Syrup/Suspension:

• Beta-blockers (e.g., propranolol, atenolol) can counteract the effects of procaterol, as they block beta-adrenergic receptors.
• Xanthine derivatives like theophylline may increase the risk of cardiovascular side effects when used with procaterol.
• Diuretics, especially loop diuretics, can enhance the hypokalemic effect of procaterol.
• Procaterol may interact with other sympathomimetic agents (e.g., epinephrine, salbutamol), leading to an exaggerated cardiovascular response.
• Antifungal medications such as ketoconazole can increase procaterol levels by inhibiting its metabolism.
• The combination of procaterol with other drugs that prolong the QT interval (e.g., certain antiarrhythmics, antipsychotics) may increase the risk of cardiac arrhythmias.
• Non-potassium sparing diuretics may cause a decrease in potassium levels, which can increase the risk of arrhythmias when used with procaterol.

Following are the food interactions for Procaterol Syrup/Suspension:

• Procaterol may interact with caffeine-containing foods and beverages, such as coffee, tea, and certain soft drinks. These substances can enhance the stimulant effect of Procaterol and increase side effects like nervousness and rapid heartbeat.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the enzyme CYP450 3A4, potentially altering Procaterol's metabolism and increasing its concentration in the body.
• Avoid alcohol consumption while using Procaterol, as it may increase the risk of side effects, particularly cardiovascular issues.
• High-fat meals may delay the absorption of Procaterol, leading to a potential reduction in its effectiveness.
• Dairy products like milk and cheese may also interact with Procaterol, as they can bind to the medication and reduce its absorption, affecting its efficacy.
• Procaterol's effectiveness may be influenced by high-fiber foods, which can decrease its absorption.
• It is advisable to maintain a balanced diet and consult a healthcare professional for personalized advice regarding food interactions with Procaterol.
• Always follow the medication guidelines provided by your healthcare provider for optimal safety and effectiveness.

Procaterol Syrup/Suspension should be stored in a cool and dry place, preferably at room temperature, ensuring it is not exposed to direct sunlight or moisture. Keep the medication securely sealed in its original container to maintain its integrity and prevent contamination. Avoid storing it in areas like the bathroom or near heat-emitting appliances to prevent temperature-related degradation. Always adhere to the expiration date on the packaging and responsibly dispose of any unused or expired medication. For safe disposal, refrain from flushing it down the toilet or pouring it into drainage systems; instead, consult a pharmacist or healthcare professional for guidance on proper disposal methods. Keep the medication securely stored away from children to prevent accidental consumption.

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Following are the quick tips for Procaterol Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Administer the prescribed dose using the measuring cup provided.
• Ensure the medication is well-mixed before each use by gently shaking the bottle.
• Procaterol is typically taken twice a day; maintain a consistent schedule for best results.
• Avoid missing doses; if you miss one, take it as soon as you remember, unless it's almost time for your next dose.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Regularly monitor your breathing and consult your doctor if symptoms worsen or persist.