PROCAINE PENICIL 4LAC

PROCAINE PENICIL 4LAC

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  • Manufacturer PDH Pharmaceuticals (Pvt.) Ltd.
  • Generic Name Procaine Penicillin

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Procaine Penicillin Injection, a combination of penicillin G and procaine, exerts its antibacterial effect through the inhibition of bacterial cell wall synthesis. Penicillin G primarily targets the transpeptidation step in the synthesis of peptidoglycan, a crucial component of bacterial cell walls. By binding to specific penicillin-binding proteins (PBPs), it disrupts the cross-linking of peptidoglycan chains, leading to weakened cell walls and eventual cell lysis. Procaine, a local anesthetic, enhances the effectiveness of penicillin by prolonging its presence at the injection site, allowing for sustained antibacterial activity. This combination ensures the delivery of penicillin G to the site of infection, enabling it to exert its bactericidal effect against susceptible microorganisms.

  • Ingredients

    Procaine Penicillin
  • Drug Class

    Penicillin.

  • Dosage Form

    Injection

  • Uses

    The following are the uses of Procaine Penicillin Injection:

    • Used for treating various bacterial infections such as pneumonia, syphilis, and meningitis.
    • Used for combating infections that are susceptible to the penicillin group of antibiotics.
    • Used for managing severe throat, ear, and dental infections.
    • Used for treating respiratory tract infections caused by Streptococcus bacteria.
    • Used for addressing skin and soft tissue infections, including cellulitis.
    • Used for preventing recurrence of rheumatic fever in susceptible individuals.
    • Used for controlling infections in patients with weakened immune systems.
    • Used for providing rapid relief in acute exacerbations of chronic bacterial infections.
  • In case of Overdose

    In the case of an overdose of Procaine Penicillin Injection, it is important to recognize and act promptly. Symptoms may include severe allergic reactions, such as difficulty breathing, skin rashes, and swelling. Other signs of overdose could include gastrointestinal issues like nausea, vomiting, and diarrhea. If an overdose is suspected, immediate medical intervention is necessary. This may involve seeking emergency care for supportive treatment and management of any adverse reactions.

  • Missed Dose

    In the case of a missed dose of Procaine Penicillin Injection, it is important to administer the missed dose as soon as possible. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you miss multiple doses or are unsure about how to adjust your medication schedule. It is crucial to maintain a consistent medication routine for the best treatment outcomes.

  • How To Use

    To administer Procaine Penicillin Injection, clean the injection site, insert the needle at a 90-degree angle, and inject the prescribed dose slowly, ensuring the entire medication is delivered, following the instructions provided by your healthcare professional for proper administration.

  • When Not to Use

    Here are the conditions or situations when Procaine Penicillin Injection should not be used:

    • Should not be administered to individuals with a history of severe allergic reactions to penicillin or any other beta-lactam antibiotics.
    • Contraindicated in patients with a known allergy to procaine or any local anesthetics.
    • Not recommended for patients with a history of epilepsy or other seizure disorders.
    • Should not be used in individuals with heart block or other heart rhythm disorders.
    • Contraindicated during the last stages of pregnancy, especially near term, due to the risk of neonatal jaundice.
    • Not suitable for patients with known or suspected bacterial infections caused by penicillinase-producing microorganisms.
    • Should be avoided in patients with a history of liver or kidney disease.
    • Not recommended for individuals with mononucleosis or lymphatic leukemia.
  • Side Effects

    The side effects of Procaine Penicillin Injection may include:

    • Pain, redness, or swelling at the injection site
    • Nausea or vomiting
    • Diarrhea or upset stomach
    • Skin rash or itching
    • Fever or chills
    • Dizziness or lightheadedness
    • Allergic reactions such as hives, swelling, or difficulty breathing
    • Anaphylaxis (a severe allergic reaction) in rare cases
    • Headache or mild fatigue
    • Temporary numbness or tingling near the injection site
    • Jarisch-Herxheimer reaction (flu-like symptoms) in some cases of syphilis treatment
    • Rare risk of seizures with high doses
    • Injection site abscess or infection in rare cases
  • Precautions & Warnings

    Following are the precautions and warnings for Procaine Penicillin Injection:

    • This medication should not be used in individuals with a history of allergic reactions to penicillin or any other penicillin derivatives.
    • Procaine Penicillin should be used with caution in patients with known allergies to other medications or substances, as cross-reactivity may occur.
    • It is crucial to complete the full course of treatment as prescribed, even if symptoms improve, to ensure the infection is completely eradicated.
    • Patients with a history of gastrointestinal problems, especially colitis, should be closely monitored as penicillin may cause gastrointestinal issues.
    • Caution is advised in patients with kidney or liver impairment, as dosage adjustments may be necessary to avoid accumulation of the drug.
    • Procaine Penicillin should be administered slowly, and patients should be observed for any signs of allergic reactions during and after the injection.
    • Pregnant and breastfeeding women should consult their healthcare provider before using this medication, as it may have potential risks to the fetus or infant.
    • If any severe or persistent side effects occur, such as severe diarrhea, skin rash, or difficulty breathing, medical attention should be sought immediately.
  • Drug Interactions

    Following are the drug interactions for Procaine Penicillin Injection:

    • Probenecid slows the renal excretion of penicillin and can increase penicillin serum levels, prolonging its effect.
    • Anticoagulants like warfarin may have their effects enhanced, increasing the risk of bleeding.
    • Tetracyclines can form inactive complexes with penicillin, reducing the effectiveness of both drugs.
    • Procaine penicillin may decrease the efficacy of oral contraceptives, requiring additional contraceptive measures.
    • Concurrent use with methotrexate can increase methotrexate toxicity due to reduced renal clearance.
    • The effectiveness of some live bacterial vaccines (e.g., typhoid vaccine) may be reduced by penicillin.
    • May reduce the absorption of mycophenolate mofetil, potentially decreasing its immunosuppressive effect.
  • Food Interactions

    Following are the food interactions for Procaine Penicillin Injection:

    • Procaine Penicillin should be administered on an empty stomach, at least one hour before or two hours after meals, to ensure optimal absorption.
    • Avoid consuming alcohol during the treatment period as it may reduce the effectiveness of the medication and increase the risk of side effects.
    • Grapefruit and grapefruit juice are to be avoided as they can affect the metabolism of the drug, potentially leading to increased levels of penicillin in the body.
    • Dairy products, especially milk, may interfere with the absorption of Procaine Penicillin, so it is best to separate milk consumption from medication timing.
    • High-fat meals can delay the absorption of the drug, so it is advisable to avoid fatty foods before taking the injection.
    • Caffeine intake should be monitored as it may potentially interact with Procaine Penicillin, although the exact mechanism is not well understood.
    • Certain foods rich in vitamin K, like leafy green vegetables, may interfere with the action of Procaine Penicillin if used for its anticoagulant properties.
    • No specific food restrictions are necessary, but maintaining a balanced diet is recommended for overall health during the treatment process.
  • Storage/Disposal

    Procaine Penicillin Injection should be stored in a controlled environment, preferably between 36°F and 46°F (2°C and 8°C), protected from light and moisture. It is crucial to keep the injection in its original packaging, ensuring the label remains intact for clear identification. Do not freeze the medication, as this may damage its integrity. Disposal of unused or expired Procaine Penicillin Injection should be done carefully; do not throw it into the trash or flush it down the toilet. Contact your pharmacist or healthcare provider for specific instructions on proper disposal methods, ensuring compliance with local regulations to protect the environment. Keep this medication securely stored and out of the reach of children and pets to prevent accidental exposure.

  • Quick Tips, if any

    Following are the quick tips for Procaine Penicillin Injection:

    • Procaine Penicillin is typically administered by a healthcare professional in a clinical setting.
    • Ensure you inform your doctor about any allergies or medical conditions before the injection.
    • During the injection, relax the muscle and avoid sudden movements.
    • After the injection, follow any post-care instructions provided by your healthcare provider.
    • Report any persistent pain, redness, or swelling at the injection site to your doctor.
    • Avoid missing doses to ensure the full course of treatment is completed.
    • Do not reuse or share needles, and safely dispose of medical waste.

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