Procarbizole (50mg) 100 Tablets

Procarbizole (50mg) 100 Tablets

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  • Manufacturer Pharmedic Laboratories
  • Generic Name Propylthiouracil

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Propylthiouracil (PTU) is an antithyroid medication that primarily acts by inhibiting the enzyme thyroid peroxidase (TPO). This enzyme is crucial for the synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3). By blocking TPO, PTU decreases the production of these hormones. It also exhibits an additional mechanism by competitively inhibiting the iodination of thyroglobulin, further reducing thyroid hormone synthesis. Moreover, PTU may interfere with the peripheral conversion of T4 to the more active form, T3, in tissues outside the thyroid gland. This comprehensive inhibition of thyroid hormone production and conversion makes PTU effective in controlling hyperthyroidism.

  • Ingredients

    Propylthiouracil
  • Drug Class

    Antithyroid

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Propylthiouracil Tablet:

    • Used for treating hyperthyroidism, a condition where the thyroid gland produces too much thyroid hormone.
    • Used for managing symptoms like rapid heartbeat, anxiety, and weight loss associated with an overactive thyroid.
    • Used to slow the production of thyroid hormones and reduce symptoms until thyroid function normalizes.
    • Used as a long-term treatment for Graves' disease, a common cause of hyperthyroidism.
    • Used to prepare for thyroid surgery or radioactive iodine treatment by reducing thyroid activity.
    • Used to treat thyroid storm, a severe and potentially life-threatening complication of hyperthyroidism.
    • Used to control thyroid function in patients who cannot tolerate other anti-thyroid medications.
  • In case of Overdose

    In the case of an overdose of Propylthiouracil Tablets, it is important to recognize the potential severity of the situation. Symptoms may include nausea, vomiting, diarrhea, and abdominal pain. More serious effects can include liver damage, kidney problems, and severe blood disorders. Prompt medical attention is necessary, as doctors may need to provide supportive care and manage any life-threatening complications that arise from the overdose. Seeking emergency assistance is crucial for the best possible outcome.

  • Missed Dose

    In the case of a missed dose of Propylthiouracil Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your medication regimen. It is essential to maintain a consistent medication routine, but if you encounter challenges, consult your healthcare provider for advice.

  • How To Use

    To take Propylthiouracil Tablets, swallow the tablet whole with a full glass of water, usually two to four times a day or as directed by your doctor, and it is important to follow the prescribed dosage and schedule provided by your healthcare professional.

  • When Not to Use

    Following are the conditions/situations when Propylthiouracil Tablet should not be used:

    • Must not be used in individuals with a known allergy or hypersensitivity to Propylthiouracil or any of its ingredients.
    • Contraindicated in patients with a history of severe liver disease or liver disorders.
    • Should not be used if you have a blood disorder called agranulocytosis.
    • Not suitable for individuals with an overactive thyroid (thyrotoxicosis) who are pregnant or breastfeeding.
    • Contraindicated in patients with a rare condition called thyroid storm, which is a life-threatening complication of hyperthyroidism.
    • Avoid using Propylthiouracil if you have a history of severe kidney disease or kidney failure.
    • Do not use this medication if you have a rare condition called aplastic anemia, which affects the bone marrow.
  • Side Effects

    The side effects of Propylthiouracil Tablet may include:

    • Skin rash or itching
    • Hair loss
    • Nausea and vomiting
    • Loss of taste or altered sense of taste
    • Diarrhea
    • Joint pain
    • Fatigue and weakness
    • Fever
  • Precautions & Warnings

    Following are the precautions and warnings for Propylthiouracil Tablet:

    • It should not be used in individuals with a known allergy to propylthiouracil or any of its ingredients.
    • Regular blood tests are necessary to monitor liver function, as the medication can cause liver-related side effects.
    • Propylthiouracil can suppress the production of blood cells, so blood cell counts should be monitored regularly.
    • Patients should inform their doctor about any history of kidney problems, as the dosage might need adjustment.
    • This medication may cause dizziness or blurred vision, so caution is advised when performing tasks requiring alertness.
    • Patients should avoid alcohol consumption as it may increase the risk of liver damage.
    • Propylthiouracil can cause severe skin reactions; seek medical attention if you develop a rash or skin issues.
  • Drug Interactions

    Following are the drug interactions for Propylthiouracil Tablet:

    • Concomitant use with anticoagulants like warfarin may alter the effects of warfarin, requiring close monitoring of INR.
    • Propylthiouracil can reduce the efficacy of thyroid replacement therapies like levothyroxine, necessitating dosage adjustments.
    • When combined with antithyroid drugs such as methimazole, it may increase the risk of hypothyroidism and require dosage modifications.
    • The use of beta-blockers alongside Propylthiouracil can mask the signs of hypothyroidism, requiring careful monitoring.
    • It may enhance the effects of insulin and oral hypoglycemic agents, potentially leading to hypoglycemia.
    • Propylthiouracil can interact with other medications metabolized by the liver, potentially affecting their blood levels.
    • Caution is advised when using Propylthiouracil with drugs that induce or inhibit liver enzymes, as it may impact its own metabolism.
  • Food Interactions

    Following are the food interactions for Propylthiouracil Tablet:

    • Consuming iodine-rich foods like seafood, seaweed, iodized salt, and dairy products should be monitored and limited as Propylthiouracil can affect iodine metabolism.
    • Cruciferous vegetables like broccoli, cauliflower, and cabbage may interfere with thyroid function and should be consumed in moderation.
    • Soy-based foods and beverages can impact thyroid hormone production and absorption, so consult your doctor for guidance on soy intake.
    • Alcohol may increase the risk of liver problems, especially with long-term use of Propylthiouracil, and should be avoided or limited.
    • Avoid grapefruit and grapefruit juice as they may alter the drug's metabolism, potentially affecting its effectiveness.
    • Caffeine-rich beverages like coffee and energy drinks may enhance the drug's side effects and should be consumed with caution.
    • A balanced diet with a variety of whole grains, lean proteins, fruits, and vegetables is recommended to support overall health while taking Propylthiouracil.
  • Storage/Disposal

    Propylthiouracil Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to expose the tablets to extreme temperatures, so avoid storage in bathrooms or near heat-emitting appliances. Regularly check the expiration date, and if the tablets are no longer needed or have expired, proper disposal is essential. Do not dispose of them in household waste or down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication securely locked away from children to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Propylthiouracil Tablet:

    • Take the tablet as directed by your doctor, usually 2-3 times a day with or without food.
    • Ensure you complete the full course of medication as prescribed, even if you feel better.
    • Propylthiouracil can take several weeks to show its full effect, so be patient and consistent with your treatment.
    • If you experience nausea, taking the tablet with food or milk can help.
    • Avoid grapefruit and grapefruit juice as they may interact with the medication.
    • Regularly monitor your thyroid function and blood cell counts while on this medication.
    • Inform your doctor about all medications and supplements you are taking to avoid potential interactions.

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