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Progesterone binds to progesterone receptors in the endometrium, promoting the secretory phase of the menstrual cycle and preparing the endometrial lining for potential implantation of a fertilized egg. It also regulates menstrual cycles and maintains pregnancy by modulating uterine conditions.
Progestin
Menstrual disturbances, premenstrual-like syndrome (including bloating, fluid retention, breast tenderness), weight change, nausea, headache, dizziness, insomnia, drowsiness, depression, change in libido, also skin reactions (including urticaria, pruritus, rash and acne), hirsutism and alopecia. Jaundice and anaphylactoid reactions have also been reported.
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Progestogens should be used with caution in conditions that may worsen with fluid retention e.g. epilepsy, hypertension, migraine, asthma, or cardiac dysfunction and in those susceptible to thromboembolism (particular caution with high dose, history of depression. Progestogens can decrease glucose tolerance and patients with diabetes should be monitored closely
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The drug interactions with progesterone include:
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