Progynon (10mg/ml) 10 Ampoule Injections

The mechanism of action of Estradiol 10mg injection revolves around its role as a potent estrogen receptor agonist. Upon administration, estradiol molecules bind to estrogen receptors in various target tissues, leading to a conformational change in the receptor structure. This activation triggers a cascade of intracellular events, primarily involving the regulation of gene expression. Estradiol influences the transcription of specific genes by interacting with estrogen response elements (EREs) in the DNA, resulting in the modulation of cellular processes such as proliferation, differentiation, and metabolism. This hormonal action contributes to the development and maintenance of secondary sexual characteristics, bone density regulation, and the modulation of various physiological functions in target organs.

Estradiol 10mg

Estrogen.

Injection

The following are the uses of Estradiol 10mg injection:

• Used for treating symptoms of menopause, including hot flashes, night sweats, and vaginal dryness.
• Used for managing hormone replacement therapy in postmenopausal women.
• Used for treating certain types of breast cancer in women whose cancer is estrogen-receptor positive.
• Used for preventing osteoporosis in women at high risk, helping to maintain bone density.
• Used for regulating menstrual cycles in women with irregular or absent periods.
• Used for treating certain hormonal imbalances in young females, such as delayed puberty.
• Used for managing transgender women's gender dysphoria as part of feminizing hormone therapy.

In the case of an overdose of Estradiol 10mg injection, prompt medical attention is necessary. Symptoms may include nausea, vomiting, breast tenderness, and increased vaginal bleeding. Seek emergency medical care if you suspect an overdose, as this can lead to serious health complications. Treatment options for overdose may involve supportive care and monitoring, focusing on managing symptoms and ensuring the patient's well-being. It is crucial to act swiftly and seek professional assistance.

In the case of a missed dose of Estradiol 10mg injection, it is important to follow the recommended guidelines. If you realize you've missed a dose, administer the injection as soon as possible, but avoid doubling the dose to compensate. If the timing is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is crucial not to alter the dosage without consulting your healthcare professional, as this medication requires careful monitoring. Remember, maintaining a consistent medication routine is essential for the effectiveness of Estradiol treatment.

To administer the Estradiol 10mg injection, clean the injection site, insert the needle at a 90-degree angle, inject the medication slowly, and then safely dispose of the used needle and syringe after withdrawing it smoothly.

Following are the conditions when Estradiol 10mg injection should not be administered:

• Should not be used in individuals with a known allergy or hypersensitivity to Estradiol or any other estrogen medications.
• Contraindicated in women who have a history of blood clots or active thrombophlebitis (blood clots in veins).
• Not suitable for individuals with a history of stroke, heart attack, or severe cardiovascular diseases.
• Should not be used in women with untreated high blood pressure (hypertension).
• Contraindicated in patients with liver disease or active liver disorders, including liver tumors.
• Not recommended for women with estrogen-dependent cancers such as breast cancer or endometrial cancer.
• Should be avoided in individuals with undiagnosed abnormal vaginal bleeding.
• Contraindicated during pregnancy as it may cause harm to the developing fetus.

The side effects of Estradiol 10mg injection may include:

• Nausea and vomiting
• Breast tenderness or swelling
• Water retention and bloating
• Mood changes, including irritability and depression
• Headaches or dizziness
• Increased risk of blood clots
• Changes in libido
• Breakthrough bleeding or spotting

Following are the precautions and warnings for Estradiol 10mg injection:

• Not recommended for individuals with a history of allergic reactions to estradiol or any other estrogen medications.
• Patients with a history of blood clots, stroke, or heart attack should use with caution, as estrogen can increase the risk of these conditions.
• Regular medical check-ups are advised to monitor blood pressure, blood sugar, and cholesterol levels.
• Not suitable for individuals with liver disease or a history of liver problems, as it can affect liver function.
• May increase the risk of gallbladder disease, so those with a history of gallstones should be monitored closely.
• Women with a history of breast or uterine cancer should not use this medication without consulting a healthcare professional.
• May cause fluid retention, so patients with heart or kidney problems should be monitored for any signs of worsening symptoms.

Following are the drug interactions for Estradiol 10mg injection:

• Estradiol may interact with Cytochrome P450 (CYP) 3A4 enzyme inducers like rifampin, potentially reducing estradiol levels and its effectiveness.
• Concomitant use with CYP3A4 inhibitors such as ketoconazole and itraconazole can increase estradiol levels, leading to enhanced effects and side effects.
• The risk of thromboembolic events may be increased when combined with oral contraceptives or other estrogen-containing products.
• Estradiol can decrease the effectiveness of thyroid hormone replacement therapy, requiring close monitoring of thyroid function.
• Caution is advised when using with corticosteroids, as it may increase the risk of fluid retention and edema.
• The effects of certain anti-diabetic medications may be reduced by estradiol, necessitating careful blood glucose monitoring.
• Estradiol may interact with herbal supplements like St. John's Wort, potentially reducing its own levels and effectiveness.

Following are the food interactions for Estradiol 10mg injection:

• Consumption of grapefruit or grapefruit juice should be avoided as it may interfere with the metabolism of Estradiol, potentially leading to increased levels in the body.
• Alcohol intake may increase the risk of certain side effects like nausea and dizziness, so it's advisable to limit or avoid alcohol consumption during treatment.
• Fatty foods may affect the absorption rate of Estradiol, possibly leading to variations in blood levels.
• Avoid high-salt foods as Estradiol can cause sodium retention, and excessive salt intake may exacerbate this effect.
• Foods rich in vitamin K, like leafy greens, should be consumed in moderation as they can counteract the anticoagulant effects of Estradiol.
• Caffeine-rich foods and beverages might interact with Estradiol, potentially affecting its metabolism and effectiveness.
• Limit soy products as they contain phytoestrogens, which may interfere with the action of Estradiol.
• Always consult a healthcare professional for personalized advice on diet and medication interactions.

Estradiol 10mg injection should be stored in a controlled environment, specifically at room temperature between 20°C and 25°C (68°F to 77°F), ensuring it is protected from light and moisture. It is crucial to keep the injection in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing it to extreme temperatures, including freezing conditions or direct heat sources like radiators or ovens. Always check the expiration date, and never use the injection if it has expired. When disposing of unused or expired Estradiol injections, do not flush or pour them down the drain. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for Estradiol 10mg injection:

• Consult your doctor to determine the appropriate dosage and injection schedule.
• Ensure the injection is administered by a trained healthcare professional.
• Verify the medication's expiry date and inspect for any discoloration or particles before use.
• Relax the muscle and clean the injection site with an alcohol swab prior to injection.
• Dispose of used needles and syringes safely in designated sharps containers.
• Report any persistent pain, swelling, or redness at the injection site to your healthcare provider.
• Store the medication as directed, typically at room temperature, away from direct sunlight and moisture.