Progynova (2mg) 21 Tablets

Estradiol Valerate 2mg Tablets work by acting as a potent estrogen receptor agonist. Once absorbed, estradiol valerate is converted to estradiol in the body, which is the primary female sex hormone. Estradiol binds to estrogen receptors in various tissues, including the uterus, breasts, and bones. This binding triggers a series of intracellular events, leading to the activation of gene expression and subsequent physiological responses. In target tissues, estradiol promotes the growth and maintenance of female reproductive tissues, regulates the menstrual cycle, and helps prevent bone loss. It also exerts its effects on lipid metabolism, cardiovascular system, and cognitive functions. The estrogenic activity of estradiol valerate helps alleviate symptoms of estrogen deficiency and is used in hormone replacement therapy.

Estradiol Valerate 2mg

Estrogen

Tablet

The following are the uses of Estradiol Valerate 2mg Tablet:

• Used for treating menopausal symptoms like hot flashes and night sweats.
• Used for managing hormonal imbalances in transgender women during gender affirmation.
• Used for relieving vaginal symptoms such as dryness and irritation.
• Used for treating certain types of breast cancer in women.
• Used for preventing osteoporosis in postmenopausal women.
• Used for regulating menstrual cycles and treating menstrual disorders.
• Used for managing hormonal deficiencies in women with ovarian failure.

In the case of an overdose of Estradiol Valerate 2mg Tablets, individuals may experience symptoms such as nausea, vomiting, breast tenderness, and increased vaginal bleeding. It is important to seek medical advice promptly if you suspect an overdose. Treatment options may include supportive care, monitoring of vital signs, and potentially administering medications to counteract the effects of the excess estrogen. Quick response and medical intervention are vital to managing the situation effectively and ensuring the patient's well-being.

In the case of a missed dose of Estradiol Valerate 2mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, consult your healthcare professional for advice on how to safely adjust your dosing schedule and ensure you're taking the medication as prescribed.

To take Estradiol Valerate 2mg Tablets, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, without crushing or chewing the tablet.

Here are the circumstances when Estradiol Valerate 2mg Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Estradiol Valerate or any other estrogen medications.
• Contraindicated in women who have a history of blood clots or thromboembolic disorders.
• Not recommended for individuals with a current or past history of breast cancer or estrogen-dependent tumors.
• Should not be used in women with undiagnosed abnormal vaginal bleeding.
• Contraindicated in patients with liver disease, liver tumors, or active liver disorders.
• Not suitable for individuals with a history of stroke or heart attack.
• Should be avoided in women with a strong family history of breast cancer or endometrial cancer.
• Contraindicated during pregnancy as it can cause harm to the developing fetus.
• Not recommended for individuals with a history of deep vein thrombosis (DVT) or pulmonary embolism.
• Should not be used in patients with a known or suspected estrogen-dependent cancer, such as endometrial cancer.

The side effects of Estradiol Valerate 2mg Tablet may include:

• Nausea and vomiting
• Breast tenderness or swelling
• Headaches or dizziness
• Mood changes, including irritability and depression
• Breakthrough bleeding or spotting
• Increased risk of blood clots
• Leg cramps or swelling

Following are the precautions and warnings for Estradiol Valerate 2mg Tablet:

• Not recommended for individuals with a history of allergic reactions to estradiol or any other estrogen medications.
• Patients with a history of blood clots, stroke, or heart attack should use this medication with caution, as it may increase the risk of these conditions.
• Regular medical monitoring is advised, including breast and pelvic exams, as well as blood tests, to ensure safe and effective use.
• Smoking while taking this medication increases the risk of blood clots, stroke, and heart attack, so quitting smoking is strongly advised.
• This medication may cause fluid retention, so those with kidney, heart, or liver disease should be monitored closely.
• May cause dizziness or lightheadedness, so caution is advised when performing activities that require clear vision and alertness.
• Not recommended for use during pregnancy or breastfeeding without medical advice, as it may harm the baby.
• Patients with a history of hormone-related cancers should use this medication with caution and under the supervision of a healthcare professional.

Following are the drug interactions for Estradiol Valerate 2mg Tablet:

• Alcohol may increase the risk of adverse effects, such as liver damage or gastrointestinal issues.
• Estradiol can decrease the effectiveness of lamotrigine, a medication used to treat seizures and bipolar disorder.
• Certain antibiotics like rifampin can induce liver enzymes and reduce estradiol levels.
• St. John's Wort may decrease estradiol levels by increasing its metabolism.
• Antifungal medications like ketoconazole can affect estradiol metabolism and increase its levels.
• Drugs that induce certain liver enzymes (e.g., CYP3A4) may reduce estradiol levels.
• Grapefruit juice can inhibit the metabolism of estradiol, potentially increasing its levels.

Following are the food interactions for Estradiol Valerate 2mg Tablet:

• Grapefruit and grapefruit juice consumption should be limited as they can increase Estradiol Valerate levels in the blood, leading to potential side effects.
• Alcohol intake should be minimized as it may enhance the risk of cardiovascular side effects associated with Estradiol Valerate.
• High-fat meals can slightly delay the absorption of Estradiol Valerate, but this effect is generally not clinically significant.
• Avoid excessive caffeine intake, as it may interact with Estradiol Valerate and increase anxiety or nervousness.
• Soy products contain isoflavones that can weakly bind to estrogen receptors; monitor for reduced Estradiol Valerate effectiveness.
• Cruciferous vegetables like broccoli, cabbage, and kale contain compounds that may affect estrogen metabolism; consult a healthcare provider for guidance.
• Limit or avoid herbal supplements like St. John's Wort, as it can induce liver enzymes, potentially reducing Estradiol Valerate's effectiveness.
• Consult a dietician or healthcare provider for personalized advice on diet and lifestyle modifications while taking Estradiol Valerate.

Estradiol Valerate 2mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, at room temperature, maintaining a consistent temperature between 68°F and 77°F (20°C and 25°C). It is crucial to keep the tablets in their original packaging or container, tightly sealed, to maintain their integrity and prevent exposure to moisture or humidity. When disposing of unused or expired tablets, it is essential to follow local guidelines and regulations. Do not discard them in household trash or flush them down the toilet. Instead, utilize designated medication disposal programs or consult your pharmacist for safe and environmentally friendly disposal options. Keep the medication out of children's reach to prevent accidental ingestion, and ensure that it is stored in a location that is inaccessible to them. Proper storage and disposal practices are vital to ensure the safety and effectiveness of Estradiol Valerate tablets.

Following are the quick tips for Estradiol Valerate 2mg Tablet:

• Consult your doctor for the correct dosage and duration tailored to your medical needs.
• Take the tablet as a whole; do not crush, chew, or break it.
• Consume the tablet with a full glass of water for better absorption.
• Maintain a consistent schedule by taking the medication at the same time each day.
• If you experience nausea, taking the tablet with food may help alleviate discomfort.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.