Promethazine (10mg) 500 Tablets

Promethazine HCl 10mg tablets primarily exert their effects through multiple mechanisms of action. It acts as a potent first-generation antihistamine, competitively blocking H1-receptor sites, thereby preventing histamine-induced effects. This action helps alleviate symptoms associated with allergic reactions and inflammation. Additionally, promethazine exhibits anticholinergic properties, reducing the activity of acetylcholine in the central and peripheral nervous systems, which contributes to its sedative and antiemetic effects. The drug also possesses local anesthetic properties and can inhibit the response of the vomiting center to visceral stimuli, further enhancing its antiemetic action. Moreover, promethazine can act as a weak serotonin antagonist, potentially influencing various physiological processes. By modulating these receptors and pathways, promethazine HCl effectively manages conditions such as allergies, motion sickness, and nausea.

Antihistamine

Tablet

The following are the uses of Promethazine HCl 10mg Tablet:

• Used for treating allergic reactions and relieving symptoms like itching, hives, and runny nose.
• Used to manage motion sickness and prevent nausea and vomiting.
• Used for short-term treatment of insomnia, aiding in falling asleep.
• Used to provide preoperative sedation and relieve anxiety before surgeries.
• Used as an anti-nausea medication during labor and delivery.
• Used to manage symptoms of the common cold and flu, such as sneezing and congestion.
• Used for temporary relief of coughs and upper respiratory symptoms.

In the case of an overdose of Promethazine HCl 10mg Tablets, individuals may experience severe drowsiness, confusion, and respiratory depression. Other symptoms can include an irregular heartbeat, seizures, and even loss of consciousness. Prompt medical intervention is necessary, and healthcare professionals should be contacted immediately to provide appropriate treatment. They may induce vomiting or administer activated charcoal to prevent further absorption of the medication.

In the case of a missed dose of Promethazine HCl 10mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is important to maintain a consistent dosing schedule for optimal effectiveness.

To take Promethazine HCl 10mg Tablets, swallow the tablet whole with a full glass of water, following the instructions provided by your healthcare professional, typically taken once or twice a day as directed, without crushing, chewing, or breaking the tablet.

Here are the circumstances when Promethazine HCl 10mg Tablets should be avoided:

• Avoid in patients with a known hypersensitivity or severe allergic reaction to Promethazine or other phenothiazine derivatives.
• Not suitable for infants or young children, especially those under 2 years of age, due to potential severe side effects.
• Contraindicated in patients with severe central nervous system (CNS) depression or coma.
• Should not be used in patients with bone marrow depression or those with known blood dyscrasias.
• Avoid in patients with narrow-angle glaucoma or those at risk of increased intraocular pressure.
• Not recommended for individuals with severe lung diseases or severe breathing problems.
• Contraindicated during the last trimester of pregnancy due to potential fetal risk.
• Should not be used in patients with a history of seizures or those with conditions that lower the seizure threshold.

The side effects of Promethazine HCl 10mg Tablet may include:

• Drowsiness or sedation
• Dry mouth
• Blurred vision or dizziness
• Constipation
• Confusion, especially in elderly patients
• Difficulty urinating
• Skin rash or itching
• Restlessness or excitement (particularly in children)

Following are the precautions and warnings for Promethazine HCl 10mg Tablet:

• Do not use if you are allergic to Promethazine or any other phenothiazines.
• This medication may cause drowsiness and impair your thinking or reactions; avoid driving or operating heavy machinery until you know how it affects you.
• Alcohol should be avoided as it can increase the side effects of Promethazine.
• Patients with a history of respiratory issues, such as asthma or sleep apnea, should use with caution.
• Elderly patients may be more sensitive to the side effects; dosage adjustments might be necessary.
• Promethazine should be used with caution in individuals with liver or kidney disease.
• Inform your doctor if you have a history of seizures, as Promethazine may lower the seizure threshold.

Following are the drug interactions for Promethazine HCl 10mg Tablet:

• Alcohol and other central nervous system (CNS) depressants like opioids or benzodiazepines can enhance sedation and respiratory depression.
• Antihistamines and other anticholinergic drugs may increase side effects such as dry mouth, blurred vision, and urinary retention.
• Monoamine oxidase inhibitors (MAOIs) interaction can lead to severe hypertension or hyperpyrexia. Avoid concurrent use.
• Promethazine may lower the seizure threshold; caution with anticonvulsant medications.
• Anticoagulants effect may be enhanced, increasing the risk of bleeding.
• Drugs metabolized by CYP450 enzymes may have altered metabolism, requiring dosage adjustments.
• Lithium levels may be increased, requiring close monitoring.

Following are the food interactions for Promethazine HCl 10mg Tablet:

• Alcohol consumption should be avoided as it can enhance the sedative effects of Promethazine, leading to increased drowsiness and dizziness.
• Grapefruit and grapefruit juice are to be avoided as they can inhibit the enzyme CYP2D6, increasing the levels of Promethazine in the body and potentially causing adverse effects.
• Caffeine intake should be monitored as Promethazine may reduce its metabolism, prolonging its effects and potentially causing jitteriness or insomnia.
• Avoid high-fat meals as they can delay the absorption of Promethazine, affecting its onset of action.
• Promethazine may increase appetite, so a balanced diet is essential to avoid excessive weight gain.
• Certain foods with tyramine (aged cheeses, cured meats) should be limited as Promethazine can interact with them, causing a spike in blood pressure.
• Always ensure proper hydration when taking Promethazine to prevent dehydration.
• Consult your healthcare provider for personalized advice on dietary restrictions and interactions.

Promethazine HCl 10mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to expose the medication to extreme temperatures, so avoid storage in bathrooms or near heat-emitting appliances. Always check the expiration date, and for proper disposal of unused or expired tablets, consult a pharmacist or healthcare professional, avoiding flushing or draining. Responsible storage also includes keeping the medication away from children to prevent accidental consumption.

Following are the quick tips for Promethazine HCl 10mg Tablet:

• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Take the tablet as directed by your doctor, usually with a full glass of water.
• Do not crush or chew the tablet; swallow it whole for optimal absorption.
• Avoid alcohol consumption while taking this medication as it may increase drowsiness.
• Inform your doctor about all medications you are currently taking to prevent potential interactions.
• Contact your doctor if you experience persistent dizziness, difficulty breathing, or severe allergic reactions.
• Do not share this medication with others, even if their symptoms are similar.