Prothiaden (25mg) 100 Tablets

Prothiaden (25mg) 100 Tablets

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  • Manufacturer Abbott Laboratories
  • Generic Name Dosulepin Hydrochloride

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • Dosage
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Storage/Disposal
  • Description

    Dosulepin inhibits the reuptake of norepinephrine and serotonin by blocking their respective transporters in the presynaptic neurons. This leads to an increased concentration of these neurotransmitters in the synaptic cleft, enhancing mood and alleviating symptoms of depression. Additionally, dusolpin has anticholinergic properties due to its antagonism of muscarinic receptors, which can contribute to its sedative effects. It also exhibits weak antagonism at histamine H1 receptors, further contributing to its sedative and anxiolytic effects.

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  • Ingredients

    Dosulepin Hydrochloride
  • Drug Class

    Tricyclic Antidepressant

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  • Dosage Form

    Tablet

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  • Uses

    This tablet is used to treat:

    • Depression
    • Anxiety
    • Mood Disorders
    • Emotional Imbalance

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  • Dosage

    Prothiaden dosage recommendations:

    • Adult Dosage

    As a starting dose, 3 capsules a day. This may be taken as one capsule three times a day or 3 capsules as a single dose each evening, preferably a couple of hours before bedtime. Normally, not more than 9 capsules (equivalent to 225 mg dosulepin) should be taken each day.

    • Child Dosage

    Not recommended

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  • In case of Overdose

    Symptoms of overdosage may include dryness of the mouth, excitement, ataxia, drowsiness, loss of consciousness, muscle twitching, convulsions, widely dilated pupils, hyperreflexia, sinus tachycardia, cardiac arrhythmias, hypotension, hypothermia, depression of respiration, visual hallucinations, delirium, urinary retention, paralytic ileus, and respiratory or metabolic alkalosis. Treatment should consist of gastric lavage. When the patient is unconscious or the cough reflex depressed, the lungs should be protected by a cuffed endotracheal tube. Repeated gastric/intestinal aspiration or repeated administration of activated charcoal may remove the drug and metabolites excreted into the gut via the bile. Continuous ECG monitoring is advisable. Abnormalities of cardiac rhythm and epileptic convulsions may occur and should be treated accordingly. Forced diuresis is not recommended. Bedrest is advisable, even after recovery.

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  • Missed Dose

    If you miss a dose, take it as soon as you remember. If it is close to the next dose, skip the missed dose. Do not double up.

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  • How To Use

    Swallow the tablet whole with water, preferably at the same time each day. Follow the dosage instructions from your healthcare provider.

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  • When Not to Use

    Dosulpin should not be used in the following situations:

    • Hypersensitivity to the active substance or any excipients listed
    • Allergy to peanut or soya (contains soya lecithin)
    • Recent myocardial infarction
    • Heart block or other cardiac arrhythmias
    • Mania
    • Severe liver disease
    • Narrow-angle glaucoma or other causes of increased intraocular pressure

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  • Side Effects

    Unraveling the side effects lurking behind this product are the following:

    • Drowsiness
    • Dry mouth
    • Dizziness
    • Weight gain

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  • Precautions & Warnings

    Patients should be aware of the following precautions and warnings:

    • Individuals with a history of bipolar disorder or psychosis should use this medication with caution.
    • It is not recommended for patients with severe cardiovascular disease, including heart failure, conduction disorders, or cardiac arrhythmias, and those with risk factors for QTc prolongation or torsades de pointes (TdP), such as congenital long QT syndrome.
    • Those with a significant risk of suicide should be monitored closely.
    • Caution is advised for patients with glaucoma, urinary retention, or prostatic hypertrophy.
    • Avoid abrupt withdrawal of the medication to prevent potential complications.
    • Use with care in elderly patients.
    • Pregnant or breastfeeding women should consult their healthcare provider before use.

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  • Drug Interactions

    Drug interactions with dosulepin hydrochloride include:

    • Other antidepressants (e.g., selective serotonin reuptake inhibitors (SSRIs)) (may increase the risk of serotonin syndrome- use with caution)
    • Monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine) (may cause severe hypertension- avoid concomitant use)
    • CNS depressants (e.g., alcohol, benzodiazepines) (may enhance sedative effects- monitor for increased sedation)
    • Anticholinergic drugs (e.g., atropine) (may increase anticholinergic side effects such as dry mouth and constipation)
    • CYP450 inhibitors (e.g., ketoconazole) (may increase dosulepin levels- monitor for increased side effects)
    • CYP450 inducers (e.g., rifampin) (may decrease dosulepin levels- monitor for decreased efficacy)
    • Antihypertensive agents (e.g., beta-blockers) (may enhance hypotensive effects- monitor blood pressure)
    • Warfarin (may increase bleeding risk- monitor INR closely)
    • Antiepileptic drugs (e.g., phenytoin) (may decrease dosulepin levels- monitor for reduced efficacy)

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  • Storage/Disposal

    Dosulepin Hydrochloride should be stored properly to maintain its effectiveness. Store the product at a temperature between 15°C and 30°C in a cool, dry place, away from direct heat, light, and moisture. Ensure the container is tightly closed to prevent contamination. For safety purposes, keep Dosulepin Hydrochloride out of reach of children and pets to avoid accidental ingestion. It is advisable to avoid storing the product in humid or warm areas, such as bathrooms or kitchens. If you have any questions or concerns about proper storage, consult your doctor or pharmacist for further guidance to ensure the product’s quality and safety.

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