Provera (10mg) 10 Tablets

Medroxyprogesterone is a synthetic progestin that primarily exerts its effects by binding to progesterone receptors in the body. Once bound, it activates these receptors, which then dimerize and interact with specific DNA regulatory elements. This action leads to the regulation of gene expression, influencing various physiological processes. Medroxyprogesterone can suppress ovulation by inhibiting the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, which subsequently reduces the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. This suppression of gonadotropins prevents the maturation and release of oocytes from the ovaries, thereby inhibiting ovulation.

Progestin.

Tablet

The following are the uses of MEDROXYPROGESTERONE Tablet:

• Used for treating endometrial and renal carcinomas.
• Used for managing advanced endometrial and renal carcinomas.
• Used for controlling abnormal uterine bleeding.
• Used for treating secondary amenorrhea.
• Used for managing irregular menstrual cycles.
• Used for contraception in combination with estrogens.
• Used for relieving menopausal symptoms.
• Used for maintaining pregnancy in certain cases.

In the case of an overdose of MEDROXYPROGESTERONE tablets, the primary concern is the potential for excessive progesterone exposure. Symptoms of an overdose may include nausea, dizziness, and abdominal pain. It is important to seek medical advice if you suspect an overdose, as prompt assessment and supportive care may be necessary. The severity of symptoms can vary, and healthcare professionals should be consulted for appropriate management, which may involve monitoring vital signs and providing symptomatic treatment.

In the case of a missed dose of Medroxyprogesterone tablets, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication and adjust your dosing schedule.

To take MEDROXYPROGESTERONE Tablet, swallow the tablet whole with a full glass of water, following the prescribed dosage and timing as directed by your healthcare professional, typically taken at the same time each day.

Following are the conditions or circumstances when MEDROXYPROGESTERONE Tablet should be avoided:

• Must not be used in individuals with a known allergy or hypersensitivity to medroxyprogesterone or any of the tablet's components.
• Not suitable for individuals with a history of blood clots or current thromboembolic disorders.
• Contraindicated in women who are pregnant, especially during the first trimester.
• Should not be used in women with undiagnosed vaginal bleeding or a history of breast cancer.
• Not recommended for individuals with liver impairment or liver tumors.
• Avoid using this tablet in patients with a history of stroke, heart attack, or severe cardiovascular diseases.
• Contraindicated in individuals with a known or suspected genital cancer.
• Not suitable for those with a history of severe depression or mood disorders.

The side effects of MEDROXYPROGESTERONE Tablet may include:

• Changes in menstrual periods, including spotting or missed periods.
• Weight gain or swelling due to fluid retention.
• Acne or skin irritation.
• Mood changes, including depression, irritability, or anxiety.
• Headaches or migraines.
• Breast tenderness or enlargement.
• Nausea and vomiting.
• Decreased libido.

Following are the precautions and warnings for MEDROXYPROGESTERONE Tablet:

• Do not start or continue this medication if you have undiagnosed vaginal bleeding, as it may mask underlying conditions.
• Not recommended for individuals with a history of blood clots, stroke, or heart attack, as it can increase the risk of these conditions.
• Those with a history of liver disease or liver tumors should exercise caution and have regular liver function tests while on this medication.
• May cause fluid retention, so individuals with conditions like epilepsy, asthma, migraine headaches, heart problems, or kidney disease should be monitored closely.
• May increase the risk of endometrial cancer, breast cancer, or ovarian cancer, especially with prolonged use. Regular screening and monitoring are essential.
• Can cause birth defects; pregnant women should not use it. Breastfeeding women should consult their doctor as the drug can pass into breast milk.
• May cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.

Following are the drug interactions for MEDROXYPROGESTERONE Tablet:

• May reduce effectiveness of anticoagulants like warfarin, requiring close monitoring of coagulation parameters.
• Can enhance the sedative effects of central nervous system depressants like benzodiazepines and alcohol, leading to increased drowsiness and impaired judgment.
• Concomitant use with other hormonal medications, such as estrogens, may increase the risk of adverse effects and require dosage adjustments.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) might decrease the effectiveness of MEDROXYPROGESTERONE in certain conditions.
• Can potentially interact with anticonvulsants, altering their blood levels and possibly requiring dosage adjustments.
• May influence blood glucose levels, necessitating adjustments in antidiabetic medications.
• Caution is advised when combined with medications metabolized by the liver, as it may impact their metabolism and effectiveness.

Following are the food interactions for Medroxyprogesterone Tablet:

• Alcohol consumption should be limited as it may increase the risk of liver-related side effects.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of the drug, leading to increased blood levels and potential side effects.
• High-fat meals may delay the absorption of Medroxyprogesterone, but it is not necessary to avoid fatty foods entirely.
• Caffeine intake should be monitored as it may interact with the medication, causing increased heart rate and potential palpitations.
• Avoid excessive salt intake, as Medroxyprogesterone can cause fluid retention, and a high-sodium diet may exacerbate this effect.
• Avoid excessive sugar consumption, especially if you have diabetes or are at risk, as this medication can affect blood sugar levels.
• Certain herbal supplements like St. John's Wort should be used with caution as they may impact the effectiveness of Medroxyprogesterone.
• Always inform your healthcare provider about your diet and any herbal supplements you take to ensure safe and effective use of Medroxyprogesterone.

MEDROXYPROGESTERONE Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or designated storage area, away from direct sunlight, moisture, and heat. Keep the tablets in their original packaging or container, ensuring the lid is tightly sealed to maintain their integrity. It is crucial not to store them in the bathroom or kitchen, as these areas can expose the medication to humidity and temperature fluctuations. Always check the expiration date regularly, and dispose of expired or unused tablets promptly. Proper disposal methods should be followed, such as returning them to a pharmacy or a designated medication disposal program, rather than flushing them down the toilet or throwing them into the trash, to minimize environmental impact and prevent misuse. Keep the medication out of children's reach to ensure safety.

Following are the quick tips for MEDROXYPROGESTERONE Tablet:

• Consult your doctor for the right dosage and duration of this medication.
• Swallow the tablet whole with a full glass of water, preferably at the same time each day.
• Do not crush, chew, or break the tablet.
• Inform your doctor if you have a history of blood clots, heart disease, or liver problems.
• Regular medical tests and check-ups may be required while taking this medication.
• Do not stop taking the tablet abruptly without consulting your doctor.
• Store the medication at room temperature, away from moisture and heat.