PROZA D CAP

Domperidone, a medication often administered in capsule form, functions as a selective dopamine D2 receptor antagonist. Its primary mechanism of action involves blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) and the upper gastrointestinal tract. By doing so, domperidone effectively reduces nausea and vomiting by inhibiting dopamine-induced emetic responses. Additionally, it enhances gastrointestinal motility by increasing acetylcholine release in the enteric nervous system, promoting gastric emptying and reducing the symptoms associated with gastroesophageal reflux. This action is particularly beneficial in treating conditions like gastroparesis and functional dyspepsia.

Domperidone

Antiemetic, Prokinetic.

Capsule

The following are the uses of Domperidone Capsule:

• Used for treating nausea and vomiting.
• Used to stimulate gastrointestinal motility, aiding digestion.
• Used in the management of gastroesophageal reflux disease (GERD).
• Used to increase milk production in breastfeeding mothers.
• Used to relieve symptoms of bloating and abdominal discomfort.
• Used to manage certain types of migraines by reducing nausea and gastric issues.
• Used as a supportive medication in certain gastrointestinal surgeries.
• Used to treat symptoms of functional dyspepsia, such as indigestion and stomach pain.

In the case of an overdose of Domperidone Capsules, it is important to recognize the signs and act swiftly. Symptoms may include severe nausea, vomiting, dizziness, and in extreme cases, cardiac arrhythmias. Promptly contact a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the amount ingested and the patient's medical history. Quick action can help mitigate potential health risks associated with Domperidone overdose.

In the case of a missed dose of Domperidone Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure you are taking the medication correctly. It is advisable to set reminders or alarms to help you remember to take your medication on time.

To take the Domperidone Capsule, swallow it whole with a glass of water, usually 15 to 30 minutes before a meal, as directed by your healthcare professional, and ensure you follow the prescribed dosage and duration of treatment as advised by your doctor.

Following are the conditions when Domperidone Capsule should not be used:

• Should not be taken by individuals with a known allergy to Domperidone or similar medications.
• Contraindicated in patients with a history of long QT syndrome or irregular heart rhythms.
• Not suitable for individuals with gastrointestinal bleeding, obstruction, or perforation.
• Should not be used in patients with severe kidney or liver impairment.
• Contraindicated in women who are breastfeeding, as it may suppress lactation.
• Not recommended for those with an underlying tumor of the pituitary gland (prolactinoma).
• Should be avoided in patients with epilepsy or Parkinson's disease.
• Domperidone is not to be used in children under 12 years of age.
• Must not be used to treat nausea or vomiting caused by other medications or underlying conditions.

The side effects of Domperidone Capsule may include:

• Dry mouth
• Headache
• Diarrhea
• Abdominal pain
• Skin rashes
• Dizziness
• Fatigue
• Restlessness

Following are the precautions and warnings for Domperidone Capsule:

• This medication should not be used in patients with a known allergy or hypersensitivity to Domperidone or any other ingredients in the capsule.
• Caution is advised in patients with underlying heart conditions, as it may cause QT prolongation and potentially lead to serious cardiac arrhythmias.
• Domperidone should be used with caution in individuals with kidney or liver problems, as the dosage may need to be adjusted.
• It is important to avoid alcohol consumption while taking Domperidone, as it may increase the risk of certain side effects.
• Patients with a history of gastrointestinal problems, such as intestinal obstruction or bleeding, should use this medication with caution.
• Elderly patients may be more susceptible to the side effects of Domperidone, so regular monitoring is recommended.
• Domperidone should be used with caution in patients with Parkinson's disease, as it may worsen symptoms.

Following are the drug interactions for Domperidone Capsule:

• Concomitant use with certain antipsychotic drugs, such as haloperidol or pimozide, can increase the risk of cardiac arrhythmias and QT interval prolongation.
• Domperidone may interact with strong CYP3A4 inhibitors like ketoconazole, potentially increasing domperidone levels and the risk of adverse effects.
• The absorption of domperidone can be reduced by antacids containing aluminum and magnesium. Separate administration by at least 2 hours.
• Use with caution when taking other dopamine antagonists, as it may enhance their effects and increase the risk of extrapyramidal symptoms.
• It can interact with metoclopramide, another prokinetic agent, leading to increased dopamine receptor blockade and potential central nervous system effects.
• Domperidone may decrease the effectiveness of ergot-derived medications, such as ergotamine, used for migraine treatment.
• There is a potential risk of increased plasma levels of drugs metabolized by CYP3A4, including cyclosporine and certain benzodiazepines, when used with domperidone.

Following are the food interactions to consider with Domperidone Capsule:

• Avoid grapefruit and grapefruit juice as they can inhibit the enzyme CYP3A4, leading to increased blood levels of Domperidone and potentially causing cardiac side effects.
• Alcohol consumption should be avoided as it may enhance the sedative effects, resulting in increased dizziness and drowsiness.
• While there are no direct food interactions affecting Domperidone's absorption, it's advisable to adhere to the healthcare provider's instructions regarding meal timing.
• Certain high-fat meals may slightly delay the absorption of Domperidone, but this effect is generally not clinically significant.
• Avoid excessive caffeine intake as it may interact with Domperidone, potentially causing increased heart rate and nervousness.
• Spicy foods or meals rich in pepper may increase the absorption of Domperidone, which could lead to higher plasma concentrations.
• Consuming large amounts of fiber-rich foods may decrease the absorption of Domperidone, so ensure a balanced diet for optimal medication effectiveness.
• Always maintain a consistent food and medication schedule to ensure stable Domperidone blood levels and minimize the risk of side effects.

Domperidone Capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the capsules in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing them in bathrooms or near heat-emitting appliances like ovens or heaters, as temperature fluctuations can impact the medication's effectiveness. Always check the expiration date before using, and if expired or no longer needed, proper disposal is essential. Do not flush the capsules or pour them down the drain; instead, seek guidance from a pharmacist or healthcare professional for safe disposal practices. Keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Domperidone Capsule:

• Take the capsule as directed by your doctor, usually 30 minutes before meals.
• Swallow the capsule whole with a glass of water, do not crush or chew.
• Avoid alcohol as it may increase the risk of side effects.
• Inform your doctor if you have any medical conditions, especially kidney or liver problems.
• Store the capsules in a cool, dry place, away from direct sunlight.
• Do not take this medication if you have a known allergy to domperidone or similar drugs.
• If you are pregnant or breastfeeding, consult your doctor before taking this medicine.