Pruvix 2mg 30s tab

Prucalopride's mechanism of action primarily involves its activity as a selective serotonin 5-HT4 receptor agonist. It binds to these receptors in the gastrointestinal tract, specifically in the enteric nervous system. By activating 5-HT4 receptors, prucalopride enhances the release of acetylcholine, which stimulates intestinal motility. This results in increased peristalsis, improved gastric emptying, and accelerated intestinal transit time, thereby alleviating constipation. Prucalopride's selective action on 5-HT4 receptors minimizes its impact on other serotonin receptors, contributing to a reduced risk of side effects associated with non-selective serotonin receptor activation.

Gastrokinetic agent

Tablet

The following are the uses of Prucalopride 2mg Tablet:

• Used for treating chronic constipation in adults, particularly those with a condition known as chronic idiopathic constipation, where the cause is unclear.
• Used to stimulate intestinal motility, helping to move food through the digestive system more efficiently.
• Used to alleviate symptoms of constipation such as hard stools, straining during bowel movements, and a sense of incomplete evacuation.
• Used to improve bowel movement frequency and consistency, making it easier for patients to have regular and more comfortable bowel movements.
• Used to enhance the quality of life for individuals with chronic constipation, reducing discomfort and associated abdominal pain.
• Used as a long-term treatment option for constipation, providing relief and helping to manage the condition effectively.
• Used in cases where other laxative treatments have been insufficient, offering an alternative approach to constipation management.

In the case of an overdose of Prucalopride 2mg Tablets, it is important to recognize the potential risks and take appropriate action. Symptoms may include severe nausea, dizziness, and an increased heart rate. If an overdose is suspected, seek medical advice promptly. Treatment involves managing these symptoms and providing supportive care. It is crucial to store medications responsibly, keeping them out of reach of children, to prevent accidental ingestion and potential overdose.

In the case of a missed dose of Prucalopride 2mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to get back on track with your medication regimen safely. Do not adjust your dosage without consulting your doctor or pharmacist.

To take Prucalopride 2mg Tablet, swallow the tablet whole with a glass of water, preferably in the morning before breakfast, following the dosage instructions provided by your healthcare professional, who will determine the duration of treatment based on your medical condition and response to the medication.

Here are the conditions or situations when Prucalopride 2mg Tablet should not be used:

• Avoid use in patients with a known hypersensitivity or allergy to Prucalopride or any of its ingredients.
• Not suitable for individuals with a gastrointestinal obstruction or a blockage in the digestive system.
• Contraindicated in patients with severe inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) or toxic megacolon.
• Should not be used in individuals with severe kidney disease or those on dialysis.
• Not recommended for patients with severe liver impairment.
• Avoid use in patients with abdominal adhesions or abdominal surgeries.
• Do not use in individuals with severe dehydration or electrolyte imbalances.
• Contraindicated in individuals with a history of heart problems, such as irregular heart rhythms or prolonged QT intervals.

The side effects of Prucalopride 2mg Tablet may include:

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Dizziness
• Fatigue
• Insomnia
• Gastrointestinal discomfort

Following are the precautions and warnings for Prucalopride 2mg Tablet:

• Not recommended for individuals with known hypersensitivity or allergy to prucalopride or any of its excipients.
• Patients with a history of kidney or liver disease should use with caution and under medical supervision, as dosage adjustments may be necessary.
• Elderly patients may be more susceptible to the drug's side effects, so close monitoring is advised.
• Prucalopride may cause dizziness or fainting in some individuals; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• This medication should be used with caution in patients with gastrointestinal conditions such as gastrointestinal obstruction, severe inflammatory bowel disease, or toxic megacolon.
• Not recommended for use in children and adolescents under 18 years of age due to insufficient data on safety and efficacy.
• Pregnant and breastfeeding women should consult their doctor before taking this medication as the risks and benefits should be carefully considered.
• Patients with cardiovascular disease or risk factors for cardiovascular disease should be monitored closely during treatment.

Following are the drug interactions for Prucalopride 2mg Tablet:

• Avoid concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) as they can increase Prucalopride's concentration, potentially leading to increased side effects.
• CYP2D6 inhibitors like fluoxetine or paroxetine may reduce the effectiveness of Prucalopride by decreasing its metabolism.
• Macrolide antibiotics (e.g., erythromycin) may inhibit CYP3A4, resulting in elevated Prucalopride levels.
• Grapefruit juice should be avoided as it can inhibit CYP3A4, leading to increased Prucalopride exposure.
• Prucalopride may decrease the absorption of oral contraceptives, potentially reducing their effectiveness.
• The effect of Prucalopride may be reduced by opioid analgesics due to their slowing of gastrointestinal motility.
• It may increase the absorption of concomitantly administered drugs that require acidic pH for absorption.

Following are the food interactions for Prucalopride 2mg Tablet:

• Consuming grapefruit or grapefruit juice should be avoided as it can interfere with the metabolism of Prucalopride, potentially leading to increased drug levels in the blood and an elevated risk of adverse effects.
• Alcohol consumption should be limited or avoided as it may decrease the effectiveness of Prucalopride and increase the likelihood of gastrointestinal side effects.
• Fatty meals may delay the absorption of Prucalopride, so it is advisable to take the medication on an empty stomach for optimal absorption.
• Avoid high-fiber foods as they may reduce the absorption of Prucalopride, potentially making the medication less effective.
• Caffeine intake should be monitored as it can interact with Prucalopride, causing increased heart rate and blood pressure.
• Avoid excessive salt intake as it may reduce the efficacy of Prucalopride in managing constipation.
• Prucalopride may increase the absorption of sugars, so monitoring sugar intake is advisable to prevent blood sugar fluctuations.
• Keep a consistent fluid intake to maintain hydration, which aids in the effectiveness of Prucalopride in treating constipation.

Prucalopride 2mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or storage area at room temperature, ensuring it remains protected from direct sunlight, moisture, and heat. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent exposure to external elements. Always check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not throw the tablets in the trash or flush them down the toilet; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication away from children and pets to prevent accidental consumption, and ensure that it is stored in a safe and designated area.

Following are the quick tips for Prucalopride 2mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Swallow the tablet whole with a glass of water; do not crush or chew.
• Take it at the same time each day to establish a routine.
• You can take it with or without food, but be consistent with your choice.
• Do not increase the dosage without medical advice, even if symptoms persist.
• Inform your doctor about all medications you are taking to avoid interactions.
• Store the tablets in a cool, dry place, away from direct sunlight.