Lucid (400mg) 100ml Infusion

Ciprofloxacin 400mg, when administered as an infusion, exerts its antibacterial effect by inhibiting bacterial DNA gyrase, a type II topoisomerase enzyme essential for bacterial DNA replication, transcription, and repair. This inhibition leads to the destabilization of bacterial DNA, preventing the bacteria from replicating and repairing their genetic material. Ciprofloxacin specifically targets the A subunit of DNA gyrase, causing the accumulation of double-stranded DNA breaks, which ultimately results in bacterial cell death. This mechanism of action is highly effective against a wide range of Gram-negative and Gram-positive bacteria, making Ciprofloxacin a potent broad-spectrum antibiotic.

Ciprofloxacin 400mg

Quinolone Antibiotic

Infusion

The following are the uses of Ciprofloxacin 400mg Infusion:

• Used for treating severe bacterial infections that require intravenous antibiotic therapy.
• Used for serious infections like pneumonia, bone and joint infections, and abdominal infections.
• Used for rapid and potent action against a broad range of bacteria.
• Used for treating infections in patients with low immunity or severe underlying health conditions.
• Used as an alternative for patients with severe infections who cannot tolerate oral medications.
• Used to stabilize patients with life-threatening infections before switching to oral antibiotics.
• Used for surgical prophylaxis to prevent infections during high-risk surgeries.

To be taken as per doctor's prescription

In the case of an overdose of Ciprofloxacin 400mg Infusion, several symptoms may occur, including nausea, vomiting, dizziness, and headaches. The severity of these symptoms can vary based on the amount ingested. Prompt medical intervention is necessary to manage potential complications such as rapid heart rate, seizures, and respiratory distress. Treatment may involve gastric lavage, administration of activated charcoal, and supportive care to stabilize the patient's condition.

In the case of a missed dose of Ciprofloxacin 400mg Infusion, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure the treatment remains effective.

To administer Ciprofloxacin 400mg Infusion, ensure the medication is prepared by a healthcare professional, and infuse the entire contents of the vial slowly into a vein over a period of 60 minutes, as directed by your doctor.

Following are the conditions when Ciprofloxacin 400mg Infusion should not be used:

• Should not be used in individuals with a known allergy to Ciprofloxacin or other quinolone antibiotics.
• Contraindicated in patients with a history of tendon disorders or tendon rupture related to previous quinolone use.
• Not recommended for individuals with epilepsy or other seizure disorders, as it may lower the seizure threshold.
• Should be avoided in patients with central nervous system (CNS) disorders such as cerebral arteriosclerosis, increased intracranial pressure, or severe anxiety.
• Contraindicated in patients with myasthenia gravis, as it may worsen muscle weakness.
• Not suitable for individuals with a history of heart rhythm problems, especially QT prolongation.
• Should not be used in patients with kidney disease or those on dialysis, without adjusting the dose.
• Contraindicated in children and adolescents under 18 years of age, as it may affect bone and joint development.
• Should be avoided during pregnancy and breastfeeding, as it may cause harm to the developing fetus or infant.

The side effects of Ciprofloxacin 400mg Infusion may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Skin rash or itching
• Confusion or disorientation
• Increased heart rate or palpitations
• Central Nervous System (CNS) effects such as tremors, anxiety, or insomnia.

Following are the precautions and warnings for Ciprofloxacin 400mg Infusion:

• Do not use if you are allergic to Ciprofloxacin or any other quinolone antibiotics.
• Ciprofloxacin should be used with caution in patients with a history of seizures or central nervous system disorders, as it may lower the seizure threshold.
• This medication can cause tendonitis or tendon rupture, especially in older adults and those taking corticosteroids; discontinue use at the first sign of tendon pain or inflammation.
• May cause severe liver damage; monitor liver function regularly during treatment.
• Not recommended for use in pregnant or breastfeeding women due to potential risks to the fetus and infant.
• Avoid exposure to sunlight or UV rays as Ciprofloxacin may increase skin sensitivity, leading to severe sunburn.
• Patients with diabetes should monitor blood glucose levels closely as Ciprofloxacin can affect blood sugar.
• Inform your doctor about all other medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Ciprofloxacin 400mg Infusion:

• Avoid concurrent use with tizanidine, as it may lead to increased tizanidine plasma concentrations and potential for life-threatening adverse reactions.
• May reduce the effectiveness of live bacterial and viral vaccines; consider postponing vaccination until after treatment.
• Theophylline levels can be elevated, increasing the risk of theophylline-related side effects.
• When combined with cyclosporine, increased serum levels of cyclosporine may occur, potentially leading to toxicity.
• Can enhance the effects of oral anti-diabetic drugs and insulin, causing hypoglycemia.
• Avoid concurrent use with systemic corticosteroids, as it may increase the risk of tendon rupture.
• Warfarin and other anticoagulants may have their effects potentiated, requiring close monitoring of coagulation parameters.

Following are the food interactions for Ciprofloxacin 400mg Infusion:

• Avoid consuming dairy products like milk, yogurt, or cheese 2 hours before or after taking Ciprofloxacin as calcium can bind to the antibiotic, reducing its absorption.
• Caffeine intake should be limited as it may increase the side effects of Ciprofloxacin, causing restlessness and increased heart rate.
• Avoid high-iron foods like red meat, liver, and iron-fortified cereals as iron can decrease the absorption of Ciprofloxacin.
• Restrict the consumption of foods rich in zinc such as oysters, red meat, and beans, as zinc can interfere with the absorption of Ciprofloxacin.
• Vitamin and mineral supplements containing magnesium, calcium, or iron should be taken at a different time than Ciprofloxacin to avoid reduced absorption.
• Alcohol should be avoided as it may increase the risk of side effects and can cause increased drowsiness and dizziness.
• Grapefruit and grapefruit juice should be avoided as they can increase the levels of Ciprofloxloxacin in the blood, leading to potential side effects.
• Ensure adequate fluid intake and stay well-hydrated during the course of treatment.

Ciprofloxacin 400mg Infusion should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 68°F and 77°F (20°C and 25°C). Protect the infusion from direct sunlight and moisture to ensure its stability. Always keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. It is crucial not to store it in bathrooms or near heat-emitting appliances. Dispose of any unused or expired medication responsibly; do not flush or pour it down the drain. Consult your pharmacist or healthcare provider for specific instructions on proper disposal methods. Keep the infusion out of children's reach to prevent accidental consumption, as it is meant for intravenous use only.

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Following are the quick tips for Ciprofloxacin 400mg Infusion:

• Administer the infusion under medical supervision for best results.
• Ensure the infusion is prepared and administered by trained medical staff.
• Follow the prescribed dosage and duration as directed by your doctor.
• Stay well-hydrated during the treatment period.
• Inform your doctor if you have a history of kidney or liver disease.
• Avoid excessive exposure to sunlight and use sunscreen when outdoors.
• Report any side effects like rash, nausea, or dizziness to your healthcare provider immediately.