PUREGON 50IU INJ

Urofollitropin Injection, a purified form of follicle-stimulating hormone (FSH), works by stimulating the growth and maturation of ovarian follicles. It binds to FSH receptors on the ovarian follicles, initiating a signaling cascade that promotes follicular recruitment, growth, and development. This stimulation leads to an increase in follicle size, estrogen production, and the maturation of oocytes within the follicles. The mechanism of action is crucial in controlled ovarian stimulation, as it facilitates the development of multiple follicles, enhancing the chances of successful ovulation and pregnancy.

Gonadotropin

Injection

The following are the uses of Urofollitropin Injection:

• Used for stimulating the development of multiple follicles in the ovaries, aiding in the treatment of infertility.
• Used for assisting in controlled ovarian hyperstimulation during in vitro fertilization (IVF) procedures.
• Used for inducing ovulation in women with ovulatory disorders, increasing the chances of pregnancy.
• Used for improving the success rates of assisted reproductive technologies (ART) like intrauterine insemination (IUI).
• Used for treating certain types of male infertility by stimulating sperm production.
• Used for supporting ovarian function in women undergoing fertility preservation treatments.
• Used for regulating ovulation in women with polycystic ovary syndrome (PCOS) as part of a comprehensive treatment plan.

In the case of an overdose of Urofollitropin Injection, prompt medical intervention is necessary. Symptoms may include abdominal pain, bloating, and ovarian enlargement. Medical professionals should closely monitor patients, and treatment should focus on providing supportive care. It is crucial to seek emergency medical help and not attempt self-treatment in such cases, as the severity of symptoms can vary and require specialized management. Timely medical assessment is vital to address any potential complications.

In the case of a missed dose of Urofollitropin Injection, it is important to contact your healthcare provider for guidance. Missing a dose can impact the effectiveness of the medication, so it is crucial to seek professional advice. Your doctor will likely provide instructions on whether to administer the missed dose or skip it and continue with the next scheduled dose. Do not attempt to double the dose to make up for a missed one without medical supervision, as this could lead to potential side effects. It is always best to follow your prescribed treatment plan closely.

To administer Urofollitropin Injection, mix the powder with the provided diluent, gently swirl to dissolve, and then inject the prescribed dose subcutaneously or intramuscularly, as directed by your healthcare professional, ensuring proper hygiene and technique to minimize discomfort.

Following are the conditions/situations when Urofollitropin Injection should not be used:

• Should not be used in individuals with a known allergy to Urofollitropin or any related hormones.
• Contraindicated in women who are already pregnant.
• Not suitable for individuals with ovarian or uterine abnormalities, such as ovarian cysts, enlarged ovaries, or uterine fibroids.
• Should not be used in patients with a history of ovarian hyperstimulation syndrome (OHSS).
• Contraindicated in patients with primary ovarian failure or ovarian failure due to radiation or chemotherapy.
• Not recommended for individuals with untreated thyroid or adrenal gland disorders.
• Should be avoided in patients with active cancer or a history of breast, uterine, or ovarian cancer.
• Not suitable for individuals with undiagnosed abnormal vaginal bleeding.
• Should not be used in patients with severe liver or kidney disease.
• Contraindicated in women with active pelvic infections or sexually transmitted diseases.

The side effects of Urofollitropin Injection may include:

• Ovarian hyperstimulation syndrome (OHSS)
• Abdominal pain or swelling
• Nausea and vomiting
• Diarrhea
• Headaches
• Breast tenderness
• Mood changes, including depression or irritability
• Allergic reactions, such as rash, itching, or swelling at the injection site.

Following are the precautions and warnings for Urofollitropin Injection:

• This medication is intended for use under the supervision of a healthcare professional and should only be administered by trained medical personnel.
• Urofollitropin is a potent medication and should be used with caution in patients with ovarian, breast, or other hormone-dependent cancers, as it may stimulate tumor growth.
• Patients with primary ovarian failure or resistant ovaries may not respond to treatment.
• Ovarian hyperstimulation syndrome (OHSS) is a potential serious side effect; patients should be monitored for symptoms such as abdominal pain, swelling, nausea, and vomiting.
• Multiple births, including twins and triplets, are more common with fertility treatments. This increases the risk of complications during pregnancy and delivery.
• Urofollitropin may cause mild to moderate OHSS in approximately 20% of patients, and severe OHSS in 1-2% of cases.
• Patients with conditions like ovarian cysts, liver disease, or adrenal gland disorders should use this medication with caution.
• Women with thrombophlebitis or thromboembolic disorders should be carefully evaluated before starting treatment.

Following are the drug interactions for Urofollitropin Injection:

• Urofollitropin may interact with other gonadotropins, like human menopausal gonadotropin (HMG), potentially causing ovarian hyperstimulation syndrome.
• Concomitant use with clomiphene citrate can lead to an increased risk of multiple pregnancies.
• The effects of Urofollitropin may be reduced by certain hormonal medications, such as oral contraceptives, due to their influence on the pituitary-gonadal axis.
• Caution is advised when using Urofollitropin with medications that affect ovarian function, like anti-estrogen drugs, as it may alter the response to treatment.
• The risk of thromboembolic events might be elevated when Urofollitropin is combined with estrogen-containing drugs.
• Certain drugs that alter pituitary function, such as dopamine agonists, may decrease the effectiveness of Urofollitropin.
• Urofollitropin should be used cautiously in patients taking anticoagulants, as it may increase the risk of bleeding complications.

Following are the food interactions for Urofollitropin Injection:

• It is advisable to avoid grapefruit and grapefruit juice as they may interfere with the medication's metabolism, potentially altering its effectiveness.
• Alcohol consumption should be limited or avoided as it may decrease the efficacy of Urofollitropin and increase the risk of side effects.
• High-fat meals might delay the absorption of the injection, so it is best to follow medical advice regarding food intake timing.
• Caffeine intake should be monitored as it may impact hormone levels and fertility treatment outcomes.
• Avoid vitamin E supplements as they might affect blood clotting, especially during fertility treatments.
• Certain herbal supplements like St. John's Wort may interact, so discuss any herbal remedies with your doctor.
• Always maintain a balanced diet rich in essential nutrients to support overall health during the treatment period.
• Stay hydrated by drinking adequate water to support overall well-being during the injection regimen.

Urofollitropin Injection should be stored in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). It is crucial to keep the injection in its original packaging to protect it from light and moisture. Avoid freezing the medication as it may affect its potency. If the injection has been accidentally frozen, it should be discarded and not used. Always check the expiration date before use and do not use the injection if it has expired. Dispose of any unused or leftover medication by contacting your healthcare provider or pharmacist for guidance on proper disposal methods. Keep the injection out of the sight and reach of children and pets to prevent accidental exposure.

Following are the quick tips for Urofollitropin Injection:

• Administer the injection under medical supervision for fertility treatment.
• Ensure the injection is stored at the recommended temperature.
• Follow the prescribed dosage and duration for optimal results.
• Inform your doctor about any allergies or medical conditions before use.
• Report any side effects or discomfort to your healthcare provider immediately.
• Avoid missing doses; maintain consistency for effective treatment.
• Do not reuse needles or syringes; dispose of them safely.
• Stay hydrated and follow a healthy lifestyle during treatment.