PURINETONE 50MG TAB

Mercaptopurine 50MG Tablet primarily acts as a purine antimetabolite, meaning it interferes with the synthesis of purines, which are essential components of DNA and RNA. The mechanism of action involves several steps. Mercaptopurine is converted in the body to its active form, thioguanine nucleotides (TGNs), which closely resemble the natural purine bases. These TGNs then compete with the normal purine bases, primarily thymine, and are incorporated into the DNA and RNA of rapidly dividing cells, particularly those undergoing synthesis in the S-phase of the cell cycle. Once incorporated, the TGNs prevent normal base pairing, disrupt nucleic acid synthesis, and ultimately lead to cell death. This process specifically targets rapidly dividing cells, such as cancer cells or cells involved in immune responses, making it effective in the treatment of certain types of cancers and autoimmune diseases.

Purine Antimetabolite.

Tablet

The following are the uses of Mercaptopurine 50MG Tablet:

• Used for treating acute lymphocytic leukemia in children and adults, helping to stop cancer cell growth.
• Used to manage symptoms and slow the progression of Crohn's disease, an inflammatory bowel condition.
• Used in the treatment of ulcerative colitis, reducing inflammation in the digestive tract.
• Used for maintaining remission in patients with acute lymphoblastic leukemia, improving long-term outcomes.
• Used to suppress the immune system after organ transplants, preventing organ rejection.
• Used to manage certain types of anemia by regulating the immune response.
• Used in combination with other medications to enhance overall treatment effectiveness.

In the case of an overdose of Mercaptopurine 50MG Tablets, individuals may experience severe side effects. Symptoms can include a significant drop in white blood cell count, leading to increased susceptibility to infections. Other potential consequences include gastrointestinal issues like nausea, vomiting, and diarrhea, as well as potential liver damage. Prompt medical intervention is necessary, including hospitalization, to manage the complications arising from such an overdose.

In the case of a missed dose of Mercaptopurine 50MG Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is generally recommended to take the missed dose within 12 hours of the scheduled time, but if more time has passed, consult your healthcare provider for further guidance.

To take Mercaptopurine 50MG Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the circumstances under which Mercaptopurine 50MG Tablet should not be taken:

• Should not be taken if you have a known allergy to Mercaptopurine or any of its ingredients.
• Contraindicated in patients with a severe kidney impairment.
• Not recommended for individuals with a history of bone marrow suppression or blood disorders.
• Should not be used during pregnancy or breastfeeding.
• Avoid if you have active infections or a weakened immune system.
• Do not take if you have a rare hereditary problem of fructose intolerance.

The side effects of Mercaptopurine 50MG Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Stomach pain or cramps
• Diarrhea
• Mouth sores
• Increased risk of infection
• Liver problems
• Hair loss

Following are the precautions and warnings for Mercaptopurine 50MG Tablet:

• This medication should be used with extreme caution in patients with pre-existing liver conditions as it can cause liver damage. Regular monitoring of liver function is essential.
• Patients with kidney problems should exercise caution and inform their doctor, as the dosage may need adjustment.
• It may cause bone marrow suppression, leading to decreased blood cell counts. Regular blood tests are necessary to monitor blood cell levels.
• Avoid live vaccines during treatment and consult your doctor for alternative vaccination schedules.
• Inform your doctor if you have a history of allergies, as this medication may cause allergic reactions in some individuals.
• Patients should avoid alcohol consumption as it may increase the risk of liver-related side effects.
• Mercaptopurine may cause severe birth defects in pregnant women. Effective contraception is essential during treatment.

Following are the drug interactions for Mercaptopurine 50MG Tablet:

• Allopurinol can increase the risk of toxicity when taken with Mercaptopurine, leading to severe side effects.
• Mercaptopurine's effectiveness may be reduced by the use of Uridine Triacetate, which is used as an antidote for its toxicity.
• The metabolism of Mercaptopurine can be inhibited by Azathioprine, leading to increased levels and potential toxicity.
• When combined with ACE inhibitors, such as Enalapril, blood cell counts should be monitored due to potential bone marrow suppression.
• Trimethoprim, a type of antibiotic, can increase the concentration of Mercaptopurine, requiring dose adjustments.
• Vaccines, particularly live-attenuated vaccines, should be avoided as Mercaptopurine may reduce their effectiveness and increase the risk of infection.
• Interactions with other immunosuppressants like Methotrexate can increase the risk of infection and other side effects.

Following are the food interactions for Mercaptopurine 50MG Tablet:

• Alcohol intake should be avoided or limited while taking this medication as it can increase the risk of liver toxicity and gastrointestinal side effects.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Mercaptopurine, leading to increased drug levels and potential toxicity.
• Foods high in tyramine, such as aged cheeses, cured meats, and certain types of beer, should be avoided as they may interact with Mercaptopurine and increase blood pressure.
• Vitamin B6 (pyridoxine) supplements should be used with caution as they can reduce the effectiveness of Mercaptopurine by inhibiting its metabolism.
• Folic acid supplementation is recommended to reduce the risk of bone marrow suppression, a potential side effect of Mercaptopurine.
• Ensure adequate fluid intake to reduce the risk of kidney stones, as Mercaptopurine can increase uric acid levels.
• Avoid high-fat meals as they may alter the absorption of Mercaptopurine, leading to variable drug levels in the body.
• Consult a healthcare professional for personalized dietary advice, especially if you have specific dietary restrictions or medical conditions.

Mercaptopurine 50MG Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring they are kept away from direct sunlight, heat, and moisture. It's crucial to store the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. When disposing of unused or expired medication, it's important not to flush or pour them down the drain. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety. Always keep the medication out of children's reach to prevent accidental consumption, and regularly check the expiration date to ensure the tablets are within their effective period. Proper storage and disposal practices are essential to maintain the efficacy and safety of Mercaptopurine tablets.

Following are the quick tips for Mercaptopurine 50MG Tablet:

• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Ensure you complete the full course of medication as prescribed by your doctor.
• Take the tablet with a full glass of water, preferably at the same time each day.
• Avoid cutting, crushing, or chewing the tablet; swallow it whole.
• Do not double the dose to make up for a missed one; continue with the regular schedule.
• Inform your doctor about all the medications you are taking to avoid potential drug interactions.
• Regularly monitor your blood cell counts and liver function while on this medication.