Q-Bact 2g (I.M./I.V.) Injection

Sulbactam and Cefoperazone, when used together, provide a synergistic effect in treating bacterial infections. Cefoperazone is a third-generation cephalosporin antibiotic that works by inhibiting the synthesis of bacterial cell walls, leading to cell lysis and death. It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria. Sulbactam is a beta-lactamase inhibitor that prevents certain bacteria from breaking down cephalosporins like Cefoperazone. By inhibiting beta-lactamase enzymes, Sulbactam enhances the effectiveness of Cefoperazone, especially against beta-lactamase-producing bacteria that would otherwise be resistant to Cefoperazone alone.

Sulbactam 1000mg, Cefoperazone 1000mg

beta-lactam antibiotic ,cephalosporin

injection

The following are the uses of Sulbactam 1000mg and Cefoperazone 1000mg injection:

• Treatment of moderate to severe bacterial infections caused by susceptible organisms, including respiratory tract infections like pneumonia.
• Management of intra-abdominal infections such as peritonitis and abscesses.
• Treatment of skin and soft tissue infections caused by susceptible Gram-positive and Gram-negative bacteria.
• Management of urinary tract infections (UTIs) caused by susceptible bacteria.
• Treatment of gynecological infections, including pelvic inflammatory disease (PID).
• Management of bone and joint infections (osteomyelitis) caused by susceptible bacteria.
• Effective against mixed infections involving both aerobic and anaerobic bacteria.
• Used in surgical prophylaxis to prevent infections in patients undergoing major surgical procedures.

Following are the doses of Sulbactam 1000mg and Cefoperazone 1000mg injection:

• The usual dose for adults is 1000mg of Sulbactam combined with 1000mg of Cefoperazone, administered intravenously or intramuscularly every 8 to 12 hours, depending on the severity of the infection and the patient's response.
• In more severe infections, the dose may be increased to 2000mg of Sulbactam combined with 2000mg of Cefoperazone, as directed by the healthcare provider.
• The exact dose and frequency should be determined by a healthcare provider based on the patient's clinical condition, age, kidney and liver function, and any other underlying conditions.
• For pediatric patients, dosing should be carefully adjusted based on weight and clinical condition, as per the healthcare provider's recommendation.

In case of an overdose of Sulbactam 1000mg and Cefoperazone 1000mg injection, immediate medical attention should be sought. An overdose may lead to an increased risk of side effects such as diarrhea, nausea, vomiting, and potential liver or kidney complications. If the medication has been inadvertently administered in excess, it is essential not to induce vomiting or take any other actions without consulting a healthcare provider. Seek medical assistance immediately if severe symptoms such as confusion, dizziness, or abdominal discomfort occur. Always follow the prescribed dosage and usage instructions to prevent overdose.

If you miss a dose of Sulbactam 1000mg and Cefoperazone 1000mg injection, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed dose, as this could increase the risk of side effects.

To use Sulbactam 1000mg and Cefoperazone 1000mg injection, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, the medication is administered via intravenous or intramuscular injection by a healthcare professional. The injections should be given at the prescribed intervals, and it's important to complete the full course of treatment as directed. If you have any questions about how to receive the medication or concerns about the treatment plan, consult your healthcare provider for clarification.

Following are the situations when Sulbactam 1000mg and Cefoperazone 1000mg injection should not be used:

• Should not be used in individuals with a known allergy to sulbactam, cefoperazone, or any of the components of the injection.
• Contraindicated in patients with a history of hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
• Should not be used in patients with severe liver or kidney dysfunction without careful monitoring, as the medication may exacerbate these conditions.
• Not recommended in neonates with a history of hyperbilirubinemia, as cefoperazone can displace bilirubin from albumin.

The side effects of Sulbactam 1000mg and Cefoperazone 1000mg injection may include:

• Allergic reactions such as rash, itching, or swelling
• Diarrhea
• Nausea or vomiting
• Pain or irritation at the injection site
• Elevated liver enzymes
• Decreased white blood cell count (leukopenia)
• Changes in kidney function (e.g., increased serum creatinine)
• Superinfection with resistant bacteria or fungi

Following are the precautions and warnings for Sulbactam 1000mg and Cefoperazone 1000mg injection:

• Should not be used in individuals with a known allergy to Sulbactam, Cefoperazone, or any of the components of the injection.
• Caution is advised in patients with a history of hypersensitivity reactions to beta-lactam antibiotics, as they may experience allergic reactions to this combination.
• Use with caution in patients with liver dysfunction, as both Sulbactam and Cefoperazone are metabolized in the liver.
• Caution should be exercised in patients with renal impairment, as dose adjustments may be required.
• This medication may cause antibiotic-associated diarrhea, and any severe diarrhea should be reported to a healthcare provider.
• Use with caution in pregnant and breastfeeding women, and consult a healthcare provider before use.

Following are the drug interactions for Sulbactam 1000mg and Cefoperazone 1000mg injection:

• Concomitant use with other antibiotics such as aminoglycosides (e.g., gentamicin) may increase the risk of nephrotoxicity.
• Caution is required when used with anticoagulants (e.g., warfarin), as the combination may increase the risk of bleeding.
• Use with caution in patients receiving probenecid, as it can increase Cefoperazone levels by decreasing renal clearance.
• The combination may reduce the effectiveness of oral contraceptives; an alternative form of contraception may be advised during treatment.
• Avoid concurrent use with other beta-lactam antibiotics without the guidance of a healthcare provider to avoid potential overdose or additive toxic effects.

Following are the food interactions for Sulbactam 1000mg and Cefoperazone 1000mg injection:

• There are no major food interactions identified with Sulbactam and Cefoperazone. However, it is recommended to avoid alcohol consumption during treatment, as it may enhance the risk of adverse effects, particularly gastrointestinal disturbances and liver-related issues.
• It is advised to follow a balanced diet while on this medication to support overall health and minimize side effects.

Sulbactam 1000mg and Cefoperazone 1000mg injection should be stored in a cool, dry place away from direct light and heat. Keep the medication in its original packaging to protect it from moisture. The vials should not be frozen, as freezing can affect the quality of the medication. Always check the expiration date before use and dispose of any unused or expired medication appropriately. To dispose of the medication, follow the instructions provided by your healthcare provider or local waste disposal guidelines. Do not dispose of the medication in wastewater or household trash unless directed.

Following are the quick tips for Sulbactam 1000mg and Cefoperazone 1000mg injection:

• Use Sulbactam and Cefoperazone injection exactly as prescribed by your healthcare provider to ensure optimal effectiveness.
• Ensure proper reconstitution of the medication as per the healthcare provider's instructions before administration.
• The injection should be given under the supervision of a healthcare professional, as it requires intravenous or intramuscular administration.
• Inform your healthcare provider if you experience any allergic reactions or side effects during the injection.
• Avoid missing doses and complete the full course of treatment, even if you start feeling better, to prevent resistance and ensure infection is fully treated.