Q-Par (200mg) 10 Tablets

(Quetiapine) Antimanic drug; Second Generation (Atypical) Antipsychotic. Quetiapine has 5HT2 antagonistic action. It also exerts its action on dopaminergic D1 and D2 receptors. It is an antagonist for D2 receptors and 5-HT2 receptors. Anxiolytic and antidepressant effects of both quetiapine and its active metabolite norquetiapine are due to the norepinephrine transporter (NET) inhibitory potential and partial agonist activity at the 5 HT1A receptor, respectively. It treats schizophrenia blocking the D2 receptor in mesocortical and mesolimbic pathways.

Quetiapine

Tablet

Bipolar Disorder, Major Depressive Disorder (Unipolar), Schizophrenia

Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Formulations of following strength are available 25 mg; 100 mg; 200 mg; 300 mg; 50 mg; 400 mg; 150 mg. Dose must be individualized by the doctor according to the patient's condition requirement. For Schizophrenia: (Immediate release tablets) day 1; 50 mg/day orally, divided dose after every 12 hours, days 2-3; increase the dose daily in increments of 25-50 mg every 8-12 hours to 300-400mg, by day 4; further adjustments can be made in increments of 25-50mg every 12 hour at intervals not less than 2 days, dosage range; 150-750 mg/day. For Bipolar I Disorder, Mania: (Administered as monotherapy or as adjunct to lithium or divalproex) Immediate release tablets; day 1; 100mg/day divided doses every 12 hours, day 2; 200mg/day divided doses every 12 hours, day 3; 300mg/day divided doses 12 hours, day 4; 400mg/day divided doses every 12 hours, further dosage adjustments, up to 800mg/day by day 6, should be not more than 200mg/day, dosage range; 400-800mg/day, not to exceed 800mg/day. For Bipolar Disorder, Depressive Episodes: (Either immediate-release or extended-release tablets may be given; dosage titrated upward over 4 days), day 1; 50mg at bedtime, day 2; 100mg at bedtime, day 3; 200mg at bedtime, maintenance (day 4 onward); 300mg at bedtime.

Consult your doctor in case of overdose. As overdose may cause hypotension, tachycardia, and somnolence.

If you miss any dose then take the dose as soon as you remember, but if it's the time for the next dose then do not double the dose.

Take orally, if you are using extended release formulations then take with meal.

If you are hypersensitive to any of its ingredients then do not use this drug.

Constipation Urinary retention Blurred vision Delirium Cognitive dysfunction Confusion Dyslipidemia, QT prolongation Weight gain

Caution is required in patients with seizures, urinary retention, decreased GI motility, hepatic impairment and cancer.

Store below 30°C. Protect from sunlight, heat and moisture.