QARAHINE SACHET HAMDARD

The primary mechanism of action of Glycyrrhiza Glabra, commonly known as licorice root, is attributed to its active constituents, particularly glycyrrhizin and its aglycone form, glycyrrhetinic acid. These compounds exhibit anti-inflammatory and immunomodulatory effects. Glycyrrhiza Glabra works by inhibiting the production of inflammatory mediators such as prostaglandins and leukotrienes. It achieves this by downregulating the activity of enzymes like cyclooxygenase (COX) and lipoxygenase (LOX) in the arachidonic acid pathway. Additionally, glycyrrhizin has been shown to influence the immune system by modulating the production of various cytokines, promoting a balanced immune response and reducing excessive inflammation. The sachet formulation allows for the controlled release of these active components, ensuring their gradual absorption and sustained action.

Glycyrrhiza Glabra

Antitussive expectorant.

powder

The following are the uses of Glycyrrhiza Glabra Sachet:

• Used for soothing and relieving throat irritation and coughs.
• Used to reduce inflammation and promote healing in mouth sores and ulcers.
• Used for digestive issues, such as stomach ulcers and indigestion.
• Used to improve skin conditions like eczema and psoriasis.
• Used for its potential anti-inflammatory and antioxidant properties.
• Used to enhance flavor and sweetness in herbal teas and beverages.
• Used as a natural sweetener and flavoring agent in food and confectionery.
• Used in traditional medicine for various respiratory and digestive ailments.

In the case of an overdose of Glycyrrhiza Glabra Sachet, individuals may experience symptoms such as headache, fatigue, and muscle pain. An excessive intake can lead to electrolyte imbalances, causing irregular heart rhythms and high blood pressure. Promptly seek medical advice if you suspect an overdose, and provide healthcare professionals with detailed information about the quantity consumed to ensure appropriate treatment and management of potential health risks.

In the case of a missed dose of Glycyrrhiza Glabra Sachet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your treatment. It is important to maintain consistency in taking this medication as prescribed.

To use the Glycyrrhiza Glabra Sachet, empty the contents of the sachet into a cup, add hot water, stir well, and consume the herbal tea as directed by your healthcare provider or as indicated on the sachet instructions.

Following are the conditions when Glycyrrhiza Glabra Sachet should not be used:

• Avoid using if you have an allergy or sensitivity to licorice root or any of its constituents.
• Do not take if you have high blood pressure, as it can worsen hypertension.
• Contraindicated in individuals with heart-related conditions, including irregular heartbeat and congestive heart failure.
• Not suitable for pregnant or breastfeeding women.
• Avoid using if you have hormone-sensitive conditions such as breast cancer, ovarian cancer, or endometriosis.
• Should not be used by individuals with liver or kidney disease.
• Do not consume if you have low potassium levels or are taking medications that lower potassium.
• Not recommended for individuals with a history of blood clots or stroke.
• Contraindicated in patients with diabetes, as it can interfere with blood sugar control.

The side effects of Glycyrrhiza Glabra Sachet may include:

• Increased blood pressure
• Hypokalemia (low potassium levels) which can lead to muscle weakness, irregular heartbeat, and fatigue
• Edema (swelling), particularly in the legs and feet
• Headaches and dizziness
• Electrolyte imbalances
• Weakness and lethargy
• Gastrointestinal issues like stomach pain, nausea, or diarrhea
• Skin rashes or hives in rare cases

Following are the precautions and warnings for Glycyrrhiza Glabra Sachet:

• This product should not be used by individuals with a known allergy or sensitivity to licorice root or any of its constituents.
• Patients with a history of high blood pressure, heart disease, kidney disorders, or liver problems should exercise caution and consult a healthcare professional before use.
• Not recommended for long-term use, as prolonged consumption may lead to electrolyte imbalances and other health issues.
• May interact with certain medications, including diuretics, corticosteroids, and insulin; consult a doctor if you are on any medication.
• Pregnant and breastfeeding women should avoid using Glycyrrhiza Glabra Sachet unless advised by a healthcare professional.
• Keep out of reach of children. In case of accidental ingestion, seek medical attention immediately.
• Discontinue use and consult a doctor if any adverse reactions or symptoms such as headache, dizziness, or irregular heartbeat occur.

Following are the drug interactions for Glycyrrhiza Glabra Sachet:

• Glycyrrhiza can increase the effects of corticosteroids, potentially leading to excessive cortisol-like effects.
• It may interact with diuretics, reducing their effectiveness and potentially causing potassium loss.
• Licorice can decrease the metabolism of certain medications, including insulin, digoxin, and warfarin, resulting in increased levels of these drugs.
• The herb can lower blood pressure, and when combined with antihypertensive drugs, it may cause excessive hypotension.
• Glycyrrhiza may interact with oral contraceptives, potentially reducing their effectiveness.
• It can increase the risk of arrhythmias when taken with cardiac glycosides, such as digoxin.
• Licorice may affect blood glucose levels, impacting the action of antidiabetic medications.

Following are the food interactions for Glycyrrhiza Glabra Sachet:

• Licorice root, which is the primary ingredient in this sachet, should be used cautiously with foods that are high in sodium. Excessive sodium intake can increase blood pressure, and licorice can further elevate blood pressure due to its mineralocorticoid-like effects.
• Avoid excessive consumption of potassium-rich foods like bananas, oranges, and spinach. Licorice can cause potassium levels to drop, leading to muscle weakness and irregular heart rhythms.
• Limit the intake of foods containing tyramine, such as aged cheeses, cured meats, and fermented foods. Licorice may interact with tyramine, causing a sudden spike in blood pressure.
• Grapefruit and its juice should be consumed sparingly as they can inhibit the metabolism of licorice, leading to increased levels of glycyrrhizin in the body and potentially causing side effects.
• Avoid alcohol as it may exacerbate the potential side effects of licorice, such as dizziness and fatigue, and can also increase the risk of hypertension.
• Licorice can affect the absorption of certain nutrients, so ensure a balanced diet to maintain adequate nutrition.
• Consult a healthcare professional if you have concerns about potential interactions with specific foods or if you have underlying health conditions.
• It is advisable to follow the recommended dosage and consult a healthcare provider for personalized advice regarding dietary considerations.

Glycyrrhiza Glabra Sachet should be stored in a cool, dry area, preferably in a dark cabinet or storage space at room temperature. Ensure the sachets are kept away from sunlight and moisture to maintain their integrity. It is crucial to store them in their original packaging, tightly sealed, to prevent contamination. Do not expose the sachets to extreme temperatures or store them near heat sources like ovens or radiators. Regularly check the expiry date, and if any sachets are past their prime, dispose of them responsibly. Avoid flushing or pouring the contents down the drain; consult a pharmacist for guidance on proper disposal. Keep the sachets out of children's reach to prevent accidental consumption.

Following are the quick tips for Glycyrrhiza Glabra Sachet:

• Consult a healthcare professional for personalized advice and dosage recommendations.
• Mix the contents of the sachet as directed, ensuring thorough dissolution.
• Consume the mixture as prescribed, preferably at the same time daily.
• Consider taking it with a glass of water for easy consumption.
• Avoid consuming with dairy products or hot beverages for optimal absorption.
• Store the sachets in a cool, dry place, away from moisture and direct sunlight.
• Do not use if the sachet is torn or shows signs of tampering.