QUININE SULPHATE 300MG TAB

Quinine 300MG Tablet primarily acts by interfering with the growth and replication of certain parasites, particularly those belonging to the Plasmodium species, which cause malaria. Its mechanism of action involves inhibiting the hemozoin biocrystallization process within the parasite. Normally, the malaria parasite digests hemoglobin, releasing toxic ferriprotoporphyrin IX (FP), which it manages to detoxify by converting it into an insoluble crystalline form called hemozoin. Quinine disrupts this process by binding to FP and inhibiting its conversion to hemozoin, leading to the accumulation of toxic FP within the parasite. This disruption ultimately results in the death of the Plasmodium parasite, thereby treating malaria.

Antimalarial, Antipyretic, Antiprotozoal.

Tablet

The following are the uses of Quinine 300MG Tablet:

• Used for treating uncomplicated malaria caused by a specific type of parasite.
• Used for reducing fever and chills associated with malaria.
• Used for preventing nighttime leg cramps in adults.
• Used to help manage muscle spasms and pain.
• Used as an antiparasitic agent, targeting the malaria-causing parasite.
• Used to improve blood circulation in certain health conditions.
• Used for its bitter flavour in tonic water, which can aid digestion.

In the case of an overdose of Quinine 300MG Tablets, several symptoms may occur, including nausea, vomiting, blurred vision, and ringing in the ears. More severe cases can lead to irregular heart rhythms, severe headaches, and confusion. If an overdose is suspected, prompt medical intervention is necessary. Seek emergency medical care, and provide healthcare professionals with the patient's medical history and details of the overdose, including the quantity and timing of ingestion.

In the case of a missed dose of Quinine 300MG Tablet, it is important to take action as soon as possible. If you remember within a few hours of the missed dose, take the tablet immediately. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is recommended to set a reminder or use a pill organizer to help you remember to take your medication as prescribed.

To take Quinine 300MG Tablet, swallow the tablet whole with a full glass of water, preferably with food, exactly as prescribed by your doctor, usually 2 to 3 times a day at the same time(s) each day.

Here are the conditions and situations when Quinine 300MG Tablet should not be taken:

• Avoid using if you have a known allergy or hypersensitivity to quinine or any other quinidine-related drugs.
• Not recommended for individuals with a history of blackwater fever or severe hemolytic anemia.
• Should not be used in patients with known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Contraindicated in individuals with a history of thrombocytopenia (low platelet count) or blood disorders.
• Not suitable for people with a history of optic neuritis or vision changes.
• Avoid using if you have a history of myasthenia gravis.
• Do not use in patients with long QT syndrome or heart rhythm disorders.
• Should not be administered to individuals with kidney disease or impaired kidney function.
• Contraindicated during pregnancy, especially in the first trimester, due to potential risks to the fetus.
• Not recommended for breastfeeding mothers, as quinine can pass into breast milk.

The side effects of Quinine 300MG Tablet may include:

• Nausea and vomiting
• Stomach pain or cramps
• Dizziness or lightheadedness
• Blurred vision or visual disturbances
• Ringing in the ears (tinnitus)
• Skin rashes or itching
• Diarrhea
• Headaches

Following are the precautions and warnings for Quinine 300mg Tablet:

• Avoid use in patients with known hypersensitivity to quinine or any of its components.
• Use with caution in patients with a history of heart problems, including arrhythmias or prolonged QT interval, as quinine can cause cardiac issues.
• May cause serious side effects like tinnitus, hearing loss, or visual disturbances; if these symptoms occur, discontinue use immediately and seek medical advice.
• Use with caution in patients with liver or kidney impairment, as quinine is metabolized in the liver and excreted by the kidneys.
• Monitor blood glucose levels regularly, as quinine may affect blood sugar levels, especially in diabetic patients.
• Quinine can interact with several medications, including anticoagulants, antacids, and antiarrhythmic drugs; inform your healthcare provider about all medications being taken.
• Avoid alcohol and other central nervous system depressants while taking quinine, as they may enhance side effects such as dizziness or drowsiness.
• May cause hematological side effects such as thrombocytopenia, leukopenia, or hemolytic anemia; regular blood tests may be required during treatment.
• Pregnant or breastfeeding women should consult a healthcare provider before use, as quinine may harm the fetus or infant.
• Do not stop taking quinine abruptly; follow the prescribed regimen to ensure effective treatment of malaria.

Following are the drug interactions for Quinine 300MG Tablet:

• Concomitant use with mefloquine can increase the risk of cardiac arrhythmias and should be avoided.
• May interact with digoxin, increasing its levels and potential toxicity. Close monitoring is required.
• Quinine can decrease the effectiveness of oral contraceptives, so alternative contraceptive methods are recommended.
• Anticoagulants like warfarin may have their effects enhanced by Quinine, requiring close monitoring of coagulation parameters.
• Antimalarial drugs like chloroquine or amodiaquine should not be used with Quinine due to increased risk of adverse effects.
• The risk of hypoglycemia may be increased when Quinine is taken with sulfonylureas or insulin.
• Caution is advised when combining Quinine with drugs that prolong the QT interval, as it may further prolong the QT interval and increase the risk of arrhythmias.

Following are the food interactions for Quinine 300MG Tablet:

• Grapefruit and grapefruit juice should be avoided as they can affect the breakdown of Quinine, leading to increased levels in the body and potential side effects.
• Alcohol consumption should be limited as it may increase the risk of adverse effects, particularly related to the central nervous system.
• Avoid caffeine-rich foods and beverages as they can enhance the stimulatory effects of Quinine, causing restlessness and sleep disturbances.
• High-fat meals may slow down the absorption of Quinine, delaying its onset of action.
• Dairy products, especially milk, can reduce the absorption of Quinine. Consider separating the medication and dairy intake by a few hours.
• Avoid salt substitutes or potassium-rich foods as Quinine can interact with potassium levels in the body.
• Certain herbal supplements, like garlic and ginseng, may interact with Quinine; consult your healthcare provider before using them.
• Always take the medication as directed by your doctor to minimize the risk of food-drug interactions.

Quinine 300MG Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial not to expose the tablets to extreme temperatures, so avoid storage in bathrooms or near heat sources like ovens or radiators. Always check the expiration date before using the medication, and dispose of any unused or expired tablets responsibly. Do not dispose of them via toilet or drainage systems; instead, seek guidance from a pharmacist or healthcare professional for appropriate disposal methods. Additionally, ensure the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Quinine 300MG Tablet:

• Start your treatment with this medication under medical supervision and inform your doctor about any existing health conditions.
• Take the tablet as directed by your doctor, typically with or after meals to minimize stomach irritation.
• Ensure you complete the full course of medication as prescribed, even if you feel better before completion.
• Do not crush or chew the tablet; swallow it whole with a glass of water for effective absorption.
• Avoid alcohol consumption while taking this medication as it may increase the risk of side effects.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your health and inform your doctor if you experience any unusual symptoms or side effects.