Rancard XR (1000mg) 14 Tablets

Ranolazine, the active ingredient in the 1000mg tablet, exerts its therapeutic effects primarily by inhibiting late sodium (Na+) currents in the heart. This mechanism is crucial in treating conditions like angina, as it reduces the intracellular sodium and calcium overload that occurs during myocardial ischemia. By inhibiting these late sodium currents, ranolazine helps to stabilize the myocardial cell membrane, thereby reducing the occurrence of arrhythmias and improving myocardial efficiency. This action results in improved diastolic function and enhanced blood flow to the heart, ultimately leading to reduced angina symptoms and improved exercise capacity in patients with cardiovascular conditions.

Antianginal agent

Tablet

The following are the uses of Ranolazine 1000mg Tablet:

• Used for treating chronic angina in patients who are not adequately controlled by other anti-anginal therapies.
• Used to reduce the frequency of angina attacks and improve exercise tolerance.
• Used to manage persistent symptoms of chest pain and discomfort.
• Used to enhance blood flow to the heart, particularly in conditions like coronary artery disease.
• Used to help control heart rate and blood pressure during physical activity.
• Used to improve overall heart function and reduce the workload on the heart.
• Used as an add-on therapy to other cardiovascular medications.

In the case of an overdose of Ranolazine 1000mg Tablets, individuals may experience an exacerbation of the drug's typical side effects. These could include severe dizziness, fainting, and an irregular heartbeat. Additionally, there may be heightened gastrointestinal issues such as nausea, vomiting, and a significant drop in blood pressure. Immediate medical intervention is necessary, and health professionals should be informed about the quantity of the medication ingested to facilitate prompt and effective treatment.

In the case of a missed dose of Ranolazine 1000mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for advice on how to safely adjust your dosage and get back on track with your medication routine. It is essential to maintain a consistent dosing schedule for the medication to be most effective.

To take Ranolazine 1000mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional, ensuring you do not exceed the prescribed amount.

Following are the conditions or situations when Ranolazine 1000mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Ranolazine or other similar medications.
• Contraindicated in patients with a specific type of heart condition called cardiogenic shock.
• Not recommended for individuals with severe liver impairment or active liver disease.
• Should not be used in patients with a history of prolonged QT interval or certain heart rhythm disorders.
• Contraindicated in patients with severe hypotension (very low blood pressure).
• Not suitable for individuals with a history of severe bradycardia (very slow heart rate).
• Should not be used concurrently with strong CYP3A inhibitors or inducers, as it may affect the metabolism of Ranolazine.
• Contraindicated in patients with a history of severe kidney disease or those on dialysis.
• Not recommended for individuals with a history of heart failure with low ejection fraction.

The side effects of Ranolazine 1000mg Tablet may include:

• Dizziness
• Headache
• Nausea and vomiting
• Constipation or diarrhea
• Fatigue and weakness
• Blurred vision
• Skin rashes or itching
• Difficulty breathing or swallowing

Following are the precautions and warnings for Ranolazine 1000mg Tablet:

• Do not start or continue the medication if you have a known allergy to Ranolazine or any other ingredients in the tablet.
• Patients with a history of liver disease should use this medication with caution, as it may affect liver function. Regular monitoring is advised.
• Ranolazine can cause a rare but serious condition called QT prolongation. Seek immediate medical attention if you experience an irregular heartbeat or fainting.
• This medication may increase the risk of dizziness or lightheadedness, especially when standing up quickly. Elderly patients should exercise caution to prevent falls.
• Diabetic patients should be aware that Ranolazine can affect blood glucose levels, so regular monitoring is necessary.
• Patients with a history of heart problems, such as heart failure or a recent heart attack, should use this medication under strict medical supervision.
• Pregnant and breastfeeding women should consult their doctor before taking Ranolazine, as its effects during these periods are not well-established.
• Inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Ranolazine 1000mg Tablet:

• Concomitant use with strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin) can increase Ranolazine levels, requiring dosage adjustments.
• Ranolazine may increase the concentration of CYP3A substrates like simvastatin, leading to potential side effects.
• The risk of QTc prolongation is higher when combined with other drugs that prolong QTc interval, such as sotalol.
• Grapefruit juice should be avoided as it can increase Ranolazine levels.
• Beta-blockers may have additive effects on heart rate and blood pressure when taken with Ranolazine.
• Digoxin levels may be increased, requiring monitoring and potential dosage adjustments.
• Anticoagulants like warfarin may have altered effects when used with Ranolazine, necessitating close monitoring.

Following are the food interactions for Ranolazine 1000mg Tablet:

• Avoid consuming grapefruit or grapefruit juice as it can affect the metabolism of Ranolazine, leading to increased drug levels in the body and potential side effects.
• Alcohol consumption should be limited as it may increase the risk of liver-related issues, especially when used long-term.
• High-fat meals can slightly increase Ranolazine absorption, so it's best to maintain a consistent diet pattern.
• Avoid consuming Seville oranges and their products, as they can affect the breakdown of Ranolazine similar to grapefruit.
• Avoid excessive caffeine intake, as Ranolazine may increase its effects, leading to potential overstimulation.
• Be cautious with dairy products; while they don't directly interact, they can affect the overall absorption of Ranolazine if consumed in large amounts.
• Always follow the dosage instructions provided by your healthcare professional, and inform them about any dietary changes or potential interactions you suspect.

Ranolazine 1000mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature, avoiding exposure to direct sunlight, moisture, or heat. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity. Regularly check the expiration date on the packaging, and if the tablets are expired or no longer needed, proper disposal is essential. Avoid flushing them down the toilet or sink; instead, consult your pharmacist or local waste management guidelines for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption, and always exercise caution when handling and storing this medication.

Following are the quick tips for Ranolazine 1000mg Tablet:

• Take the tablet as directed by your doctor, typically twice daily with meals.
• Swallow the tablet whole without crushing or chewing for optimal absorption.
• Avoid consuming grapefruit or grapefruit juice while on this medication.
• Maintain a consistent schedule for taking the medication to ensure steady blood levels.
• Do not double the dose to make up for a missed one; take it as soon as remembered if it's not close to the next dose.
• Inform your doctor about all medications you're taking to prevent potential drug interactions.
• Store the tablets at room temperature, away from moisture and light.